Motility of microscopic swimmers as protocells

Marincioni, Beatrice; Nakashima, Karina K.; Katsonis, Nathalie

doi:10.1016/j.chempr.2023.10.007

Cited by 1 publication

(1 citation statement)

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“…On the path toward complexity, processes such as compartmentalization, self-replication, metabolism, out-of-equilibrium behavior, motion, − and evolution , have been implemented in artificial chemical systems as hallmarks of living organisms . They may display adaptation to changing environments, a fundamental aspect of the emergence of life and associated complexity. , However, this feature is not exclusive to living matter.…”

Section: Introductionmentioning

confidence: 99%

Triple Adaptation of Constitutional Dynamic Networks of Imines in Response to Micellar Agents: Internal Uptake–Interfacial Localization–Shape Transition

Rieu,

Osypenko,

Lehn

2024

J. Am. Chem. Soc.

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Understanding the behavior of complex chemical reaction networks and how environmental conditions can modulate their organization as well as the associated outcomes may take advantage of the design of related artificial systems. Microenvironments with defined boundaries are of particular interest for their unique properties and prebiotic significance. Dynamic covalent libraries (DCvLs) and their underlying constitutional dynamic networks (CDNs) have been shown to be appropriate for studying adaptation to several processes, including compartmentalization. However, microcompartments (e.g., micelles) provide specific environments for the selective protection from interfering reactions such as hydrolysis and an enhanced chemical promiscuity due to the interface, governing different processes of network modulation. Different interactions between the micelles and the library constituents lead to dynamic sensing, resulting in different expressions of the network through pattern generation. The constituents integrated into the micelles are protected from hydrolysis and hence preferentially expressed in the network composition at the cost of constitutionally linked members. In the present work, micellar integration was observed for two processes: internal uptake based on hydrophobic forces and interfacial localization relying on attractive electrostatic interactions. The latter drives a complex triple adaptation of the network with feedback on the shape of the self-assembled entity. Our results demonstrate how microcompartments can enforce the expression of constituents of CDNs by reducing the hydrolysis of uptaken members, unravelling processes that govern the response of reactions networks. Such studies open the way toward using DCvLs and CDNs to understand the emergence of complexity within reaction networks by their interactions with microenvironments.

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