Motility of the pelvic colon: Part IV Abdominal pain associated with colonic hypermotility after meals

Zamifenacin (UK‐76, 654), a potent gut M3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome

“…1±15 Motility disturbances tend to be more prevalent following stimulation of the intestine by, for example, meal ingestion, 5,6 balloon distension, 9, 11±13 or intravenous infusion of cholecystokinin or pentagastrin. 17 In particular the colonic motor response to food appears to be exaggerated, 4±8 and in some patients associated with abdominal pain.…”

Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome.

“…In controls, colonic motility showed a slight increase during the stress but not significant. Many studies suggest that IBS is associated with abnormal bowel motility in response to emotional stress (Kumar and Wingate 1985), meals (Connell et al 1965), mechanical distension (Whitehead et al 1980), cholecystokinin (Harvey and Read 1973b), and neostigmine (Chaudhary and Truelove 1961b). Because the onset or exacerbation of symptoms of IBS frequently follows psychological stress (Chaudhary and Truelove 1962), it seems reasonable to assume that abnormal colonic motility is evoked by stress.…”

“…spike (Sullivan et al 1978) and in motor activity (Connell et al 1965), as observed with administrations of magnesium sulfate (Harvey and Read 1973a) and cholecystokinin (Harvey and Read 1973b). The role of gastrointestinal hormones in IBS also attracted attention.…”

Irritable Colon Syndrome

“…There must be a history of disturbance of bowel habit, either constant or intermittent, abdominal pain, usually related to the bowel dysfunction, and an absence of any radiological, bacteriological, pathological or biochemical abnormality. (Chaudhary & Truelove, 1961a (Chaudhary & Truelove, 1961b;Connell, Avery Jones & Rowlands, 1965;Wangel & Deller, 1965). This is demonstrated in two waysin the frequency of contraction of the colon, and in the overall muscular work done by it.…”