Motion Analysis of Target in Stereotactic Radiotherapy of Lung Tumors Using 320-row Multidetector CT

Imae, Toshikazu; Haga, Akihiro; Nakagawa, Keiichi; Ino, Kenji; Tanaka, Kenichirou; Okano, Yukari; Sasaki, Katsutake; Saegusa, Shigeki; Shiraki, Tomohiro; Oritate, Takashi; Yano, Keiichi; Shinohara, Hiroyuki

doi:10.6009/jjrt.67.202

Cited by 3 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This discrepancy might be due to the different CT instruments used. Our study performed DECT scanning using a 320-detector-row dynamic volume CT system, which has a z-coverage width of 160 mm and allows for faster acquisition of the entire tumor in a single rotation without bed movement (32). IWR, △HU, and λ Hu represent the change of iodine content calculated using three-material decomposition, which our CT system could more easily detect in the early stage of injection of the contrast agent.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of dual-energy computed tomography for differentiating metastatic and non-metastatic lymph nodes of colorectal cancer

Qiu¹,

Hu²,

Weng³

et al. 2021

Quant Imaging Med Surg

View full text Add to dashboard Cite

Background: Colorectal cancer (CRC) is the third most common malignancy worldwide, and lymph node metastasis is considered to be a risk factor for local recurrence and a poor prognosis in colorectal cancer.However, there remains a lack of reliable and non-invasive biomarkers to identify the lymph node status of CRC patients preoperatively. The purpose of this study was to explore the ability of dual-energy computed tomography (DECT) to differentiate metastatic from non-metastatic lymph nodes in colorectal cancer.Methods: Seventy-one patients with primary colorectal cancer underwent contrast-enhanced dual-energy computed tomography imaging preoperatively. The colorectal specimen was scanned postoperatively, and lymph nodes were matched to the pathology report. The following dual-energy computed tomography quantitative parameters were analyzed: dual-energy curve slope value (λ HU ), standardized iodine concentration (n△HU), iodine water ratio (nIWR), electron density value (nρ eff ), and effective atom-number (nZ), based on metastatic and non-metastatic lymph node differentiation. Also, sensitivity and specificity analyses were performed using receiver operating characteristic curves.Results: In all patients, one hundred and fifty lymph nodes, including 66 non-metastatic and 84 metastatic lymph nodes, were matched using the radiological-pathological correlation. Metastatic nodes had significantly greater λ HU , n△HU, and nIWR values than non-metastatic nodes in both the arterial and venous phases (P<0.01). The area under curve (AUC), sensitivity, and specificity were 0.80, 80%, and 66% for λ HU ; 0.86, 70%, and 95% for n△HU; and 0.88, 71%, and 95% for nIWR in the arterial phase. There was no significant difference in electron density and effective Z values between metastatic and non-metastatic lymph nodes.Conclusions: DECT quantitative parameters may help differentiate between metastatic and normal lymph nodes in patients with CRC.

show abstract

Section: Discussionmentioning

confidence: 99%

A prospective study of dual-energy computed tomography for differentiating metastatic and non-metastatic lymph nodes of colorectal cancer

Qiu¹,

Hu²,

Weng³

et al. 2021

Quant Imaging Med Surg

View full text Add to dashboard Cite

show abstract

“…This discrepancy might be due to the different CT instrument. In our study, we performed DECT scan in 320-detector-row dynamic volume CT system, which has a z-coverage width of 160 mm and allow a faster acquisition of entire tumor in a single rotation without bed movement [30]. IWR, △HU and λHU represent the change of iodine content calculated using three-material decomposition.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of dual-energy CT in determining the metastatic and non-metastatic lymph nodes of colorectal cancer

Qiu¹,

Hu²,

Weng³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background To explore the ability of Dual-energy CT (DECT) to differentiate metastatic from non-metastatic lymph nodes in colorectal cancer (CRC). Methods Seventy-one patients with primary CRC underwent contrast-enhanced DECT imaging before surgery. The colorectal specimen was scanned after surgery, and lymph nodes were matched to the pathology report. The DECT quantitative parameters were analyzed: dual-energy curve slope value(λHU), standardized iodine concentration (n△HU), iodine water ratio (nIWR), electron density value (nρeff), and effective atom-number (nZ), for the metastatic and non-metastatic lymph node differentiation. Also, sensitivity and specificity analyses were performed by using receiver operating characteristic curve. Results One hundred and fifty lymph nodes including 66 non-metastatic and 84 metastatic lymph nodes were matched using the radiological-pathological correlation. Metastatic node had a significantly greater λHU, n△HU and nIWR values than non-metastatic node in both arterial and venous phases (P < 0.01). The AUC, sensitivity and specificity were 0.80, 80.30% and 65.48% for λHU; 0.86, 69.70% and 95.24% for n△HU; 0.88, 71.21% and 95.24% for nIWR in the arterial phase. No significant difference was found in electron density and effective Z value for differentiation. Conclusion Dual-energy CT quantitative parameters may be helpful in diagnosing metastatic lymph nodes of CRC.

show abstract

Motion Analysis of Target during Stereotactic Radiotherapy of Lung Tumors Using Volumetric Modulated Arc Therapy

Imae

Shinohara²,

Ino³

et al. 2012

Nippon Hoshasen Gijutsu Gakkai Zasshi

View full text Add to dashboard Cite

SummaryVolumetric modulated arc therapy (VMAT) is a rotational intensity-modulated radiotherapy (IMRT) technique capable of acquiring projection images for cone-beam computed tomography (CBCT). Respiratorycorrelated cone-beam computed tomography, namely 4D-CBCT, serves to assess the displacement of a tumor position between planning and treatment due to organ motion and respiration, and is important for more accurate radiation therapy. On the other hand, recently, a 320-detector row CT scanner, namely 4D-CT, has become available that allows axial volumetric scanning of a 16-cm-long range in a patient without table movement. The goal of our research is to establish a new method of verification during treatment in stereotactic body radiotherapy. In this study, we compare the movement of the tumor between "before treatment" using 4D-CT and "in treatment" using 4D-CBCT. Three patients (55-68 years of age) with lung tumors underwent CT scans for radiotherapy planning using 4D-CT scans to analyze the movement of the tumor before treatment. The patients were treated by VMAT while acquiring projection images. 4D-CBCT datasets were reconstructed from the projection images using in-house programs. The tumor positions in 4D-CT and 4D-CBCT were detected and the movement of the tumor between "before treatment" and "in treatment" was similar. The movement of the tumors during treatment was predictable from 4D-CT before treatment. Furthermore, 4D-CBCT clarified the tumor position during treatment and could reevaluate the actual tumor position and dose distribution. We have successfully shown the movement of the tumor between "before treatment" using 4D-CT and "in treatment" using 4D-CBCT.

show abstract

Motion Analysis of Target in Stereotactic Radiotherapy of Lung Tumors Using 320-row Multidetector CT

Cited by 3 publications

References 5 publications

A prospective study of dual-energy computed tomography for differentiating metastatic and non-metastatic lymph nodes of colorectal cancer

A prospective study of dual-energy computed tomography for differentiating metastatic and non-metastatic lymph nodes of colorectal cancer

A prospective study of dual-energy CT in determining the metastatic and non-metastatic lymph nodes of colorectal cancer

Motion Analysis of Target during Stereotactic Radiotherapy of Lung Tumors Using Volumetric Modulated Arc Therapy

Contact Info

Product

Resources

About