Motion sickness-induced pica in the rat

Mitchell, Denis; Laycock, JL; Stephens, William

doi:10.1093/ajcn/30.2.147

Cited by 64 publications

(37 citation statements)

References 9 publications

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“…Indeed, regardless of the stimulus-a wide range of toxins and motion-the norm is kaolin consumption up to 6 g in 24 h (e.g., 36,53,59,60,65). We are not aware of any stimulus that produces the excessive kaolin intake reported here.…”

Section: Discussionmentioning

confidence: 66%

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Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat

Horn

Jonghe

Mátyás

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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Horn CC, De Jonghe BC, Matyas K, Norgren R. Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat. Am J Physiol Regul Integr Comp Physiol 297: R1375-R1382, 2009. First published August 26, 2009 doi:10.1152/ajpregu.00284.2009.-Anticancer agents, such as cisplatin, stimulate nausea, vomiting, and behaviors indicative of malaise. Rats and mice do not possess a vomiting response, and, therefore, in these species, the ingestion of kaolin clay (a pica response) has been used as an index of malaise. In the rat, cisplatininduced kaolin intake is inhibited by antiemetic treatments. In addition, cisplatin activates vagal afferent fibers in the gut, and kaolin intake induced by cisplatin is largely dependent on an intact vagus. Nevertheless, little is known about the brain pathways controlling pica. We investigated the role of the lateral parabrachial nucleus (lPBN), a major visceral afferent link between the hindbrain and forebrain, in cisplatin-induced c-Fos expression and pica. Injection of cisplatin (6 mg/kg ip) produced c-Fos expression in the ventrolateral (external) lPBN, a region receiving viscerosensory input. In rats with bilateral ibotenic acid lPBN lesions, cisplatin treatment substantially increased kaolin intake compared with controls (ϳ30 g vs. ϳ5 g, respectively, over 24 h). Food intake was reduced by cisplatin treatment and by apomorphine, an emetic agent that acts centrally. Unlike cisplatin, however, apomorphine stimulated kaolin intake to a similar degree in both the lesioned and control rats, suggesting that lPBN damage neither produces nonspecific effects nor enhances malaise in general. These data suggest that lPBN-lesioned animals not only demonstrate pica after cisplatin treatment, but, in fact, show an exaggerated response that is greatly in excess of any treatment known to produce kaolin intake in rats.emesis; nausea; pica; vagus; anorexia CANCER CHEMOTHERAPY AGENTS, such as cisplatin, stimulate nausea, vomiting, anorexia, and other behaviors indicative of malaise (for a review, see Refs. 2, 21, 27, 51). Several species, including dogs, cats, ferrets, pigs, and shrews, have been used to study emesis after treatment with chemotherapy agents (16,18,31,33,58). In contrast, laboratory rats and mice appear to lack a vomiting response (see Ref. 2 for review). For these species, kaolin intake has been used as a proxy for emesis (60,64). A wide variety of stimuli, including cisplatin, induce kaolin consumption in rats (36,53,59,60,65). Like emesis, geophagia appears to be a defensive response. Clay may serve to bind or dilute a toxin in the gastrointestinal (GI) tract, thus reducing its adverse effects (45, 46). After injection with cisplatin, rats consuming kaolin show less body weight loss and a smaller reduction in food intake than rats without kaolin access (12). The consumption of clay by humans is also recognized as a potential detoxification strategy (48).Despite the use of kaolin intake as an index of malaise in rats, very little is known about...

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Section: Discussionmentioning

confidence: 66%

“…For these species, kaolin intake has been used as a proxy for emesis (60,64). A wide variety of stimuli, including cisplatin, induce kaolin consumption in rats (36,53,59,60,65). Like emesis, geophagia appears to be a defensive response.…”

mentioning

confidence: 99%

Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat

Horn

Jonghe

Mátyás

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Kaolin pellets (prepared according to Mitchell et al [7,8] and Santucci et al [11]) were placed in the cages adjacent to food.…”

Section: Food and Kaolinmentioning

confidence: 99%

“…Moreover, spilled food and kaolin pieces were collected, dried and weighed to obtain correct consumption values [6][7][8]14,15]. SC group for food and kaolin were placed close to the rotation apparatus during the rotation test (see below) where they were subjected to the noise and vibration of the turntable apparatus but not rotated.…”

Section: Food and Kaolinmentioning

confidence: 99%

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Behavioural responses to hypergravity in the CD-1 mouse

et al. 2006

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Male and female mice were subjected to rotationally-generated hypergravity of different duration (1 or 2 h) and linear acceleration (2 or 1.08 G). Pica behaviour and spontaneous activity were investigated before, during, and after rotation. Moreover, hole-board and plus-maze tests were performed 20 min and 24 h after the end of rotation. Pica behaviour arose in the post-rotation days and was more pronounced after 1 h of 2 G exposure. Spontaneous activity was almost or totally suppressed during rotation and failed to regain the pre-rotational levels in the group exposed to 2 G for 1 h. Exploratory behaviour in the hole-board was also impaired. A clear effect of hypergravity exposure emerged in the plus maze, with 2 G mice totalizing a minor number of arm entries than the other groups and also showing an altered emotional/anxiety profile. Generally, females were more susceptible than males to the changes in gravitational environment.

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Horn

2013

Pain Genetics

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Motion sickness-induced pica in the rat

Cited by 64 publications

References 9 publications

Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat

Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat

Behavioural responses to hypergravity in the CD-1 mouse

Overlapping Phenotypes

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