Innovation is fundamental to organization performance and survival in a continuously changing and highly competitive world. In organizations, innovation occurs primary and foremost through purposeful and discretionary actions of knowledgeable and motivated individuals. However, despite some insightful studies, studies addressing the role of HRM in promoting innovation are in short supply. An enabling work environment—resources, motivation, and management practices—may be crucial for creativity and thus innovation. HRM policies and interventions have the potential to promote trust, cooperation, and collective codes and language. Therefore, the aim of this chapter is twofold: 1) to review the role of creativity and knowledge sharing for innovation and 2) to review the role of HRM for stimulating innovation through creativity and knowledge sharing. In so doing, the authors seek to shed light on the conceptual and analytical connections between motivation, creativity, knowledge, innovation, and HRM.