Motivation und Barrieren für die Teilnahme an klinischen Studien

Gaul, Charly; Schmidt, T.; Helm, Jürgen; Hoyer, Heike; Haerting, Johannes

doi:10.1007/s00063-006-1116-7

Cited by 10 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is also important to estimate the financial and time pressure involved for study participants and to provide support when appropriate. This might take the form of financial grants for travel costs or treatment costs, for example [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Knowledge and attitudes regarding medical research studies among patients with breast cancer and gynecological diseases

et al. 2015

View full text Add to dashboard Cite

BackgroundMedical research studies are becoming increasingly important for optimizing the prevention, diagnosis and treatment of illnesses. Participation in research studies can have many benefits for patients. In randomized and controlled clinical studies, they can receive the best possible medical care currently available. However, only a small proportion of patients nowadays are treated within the framework of medical research. The primary endpoint of this study was to discover what level of knowledge patients have about clinical studies and how they currently perceive them, in order to identify ways of optimizing the information provided about studies from the patients’ point of view.MethodsThe study included 2546 patients (breast cancer 21.6 %, gynecological cancer 8.3 %, obstetrics 32.7 %, endometriosis 7.8 %, fertility treatment 3.2 %, other benign gynecological illnesses 19.2 %, no information for 7.2 %) in the outpatient clinic (45.2 %) and in the in-patient sector (54.8 %) at the Department of Gynecology at Erlangen University Hospital and associated centers. In the single-center study, conducted between January 2011 and January 2012, the patients were asked about their level of knowledge regarding the background to medical research studies and the ways in which they are carried out and used. The patients were also asked how they perceived medical studies and how they thought study conditions might be optimized. The three-page questionnaire was included in the feedback sheet received by patients as part of the hospital’s quality management system.ResultsAs a whole, the group only had moderate knowledge about clinical studies. A majority of the respondents considered that studies were valuable (91.6 %), but only a few were also willing to take part in them (58.4 %). Knowledge and willingness to participate strongly depended on age (P < 0.001), educational level (P < 0.001) and patient group (P < 0.001). Most patients would prefer to decide about participating in studies through a discussion with their outpatient physicians.ConclusionsThe information that patients have about clinical studies affects whether they participate in them. It is therefore extremely important for patients to be well informed, for their anxieties about participation to be relieved, and for the benefits of participation to be explained to them.

show abstract

Section: Discussionmentioning

confidence: 99%

Knowledge and attitudes regarding medical research studies among patients with breast cancer and gynecological diseases

et al. 2015

View full text Add to dashboard Cite

show abstract

“…This motivation to be involved with a clinical trial may vary from person to person. Prospective participants could be motivated by the intrinsic desire to help others or to advance the horizons of knowledge in medical science 6. Some could be attracted towards a better quality of care available as part of many clinical trials 6.…”

Section: Introductionmentioning

confidence: 99%

<p>Factors Influencing Participation Of Healthy Volunteers In Clinical Trials: Findings From A Cross-Sectional Study In Delhi, North India</p>

Ranjan¹,

Agarwal²,

Kapur³

et al. 2019

PPA

View full text Add to dashboard Cite

PurposeTo identify the specific motivations that drive healthy volunteers to consent for their participation in clinical studies. Additionally, the study aimed to document the socio-demographic determinants of participation in the trial related solely to the intention of securing financial gains.Patients and methodsThis cross-sectional study was conducted among subjects who participated as healthy volunteers in clinical trials conducted by Contract Research Organizations (CROs) of Delhi. Pre-tested, validated semi-structured questionnaires were used to collect baseline socio-demographic data, information about factors motivating participation in clinical trials, and pattern of utilisation of money received against participation in the trial. Logistic regression analysis was done to determine the factors that influenced participation in the trial related purely to the motive of securing financial gains.ResultsA total of 400 participants were selected. The majority of the volunteers (77.5%) reported that their sole reason for participating in clinical trials was for monetary gain. Around a tenth of the volunteers participated with the intent to advance scientific knowledge and another 4.5% participated due to benefits of free medical check-ups. Participants in the age group of 29–38 years, those that were married, those residing in an urban slum, male participants, those with a high number of dependent family members (ie, 5 to 8), and those earning less than 5000 INR (71 USD) a month had higher odds of participating in a clinical trial purely for the financial benefits. Those educated till intermediate and above had lower odds of participation in the trial due to monetary benefits.ConclusionOur study shows that healthy volunteers in Delhi consider participation in clinical trials mainly because of the prospect of financial reward. More research is needed to inform judgments around the ethics of providing financial rewards and enrollment of healthy research volunteers.

show abstract

“…80% der klinischen Studien verfehlen den Rekrutierungszeitplan [1]. Einflussfaktoren auf die Teilnahmebereitschaft an klinischen Studien auf Patientenseite sind für Deutschland bislang wenig systematisch untersucht [2]. Generellen Einfluss haben die Schwere und Art der Erkrankung, Wirksamkeit und Zufriedenheit mit der gegenwärtigen Therapie, das persönliche Vertrauensverhältnis zum Arzt und der individuell empfundene Aufwand einer Studienteilnahme [2].…”

unclassified

“…Einflussfaktoren auf die Teilnahmebereitschaft an klinischen Studien auf Patientenseite sind für Deutschland bislang wenig systematisch untersucht [2]. Generellen Einfluss haben die Schwere und Art der Erkrankung, Wirksamkeit und Zufriedenheit mit der gegenwärtigen Therapie, das persönliche Vertrauensverhältnis zum Arzt und der individuell empfundene Aufwand einer Studienteilnahme [2]. Hinderlich ist eine ungenügende Kenntnis der besonderen Situation, die sich aus einer Studienteilnahme ergibt und von der üblichen Behandlung unterscheidet.…”

unclassified

Bereitschaft von Patienten zum Einschluss in klinische Studien

Gaul

Malcherczyk²,

Schmidt³

et al. 2010

Med Klin

Self Cite

View full text Add to dashboard Cite

Physicians recruiting patients for clinical studies should be well prepared about details of the study and should have adequate time for an introductory conversation in a quiet environment. Including relatives into the introductory conversation may enhance the motivation and therefore the success of recruitment. Potential advantages of a participation for the own treatment and additionally for other patients should be highlighted. Possible side effects should be explained in a realistic manner.

show abstract

Motivation und Barrieren für die Teilnahme an klinischen Studien

Abstract: Awareness of factors (positive and negative) which influence motivation of participation in a clinical trial is useful to provide strategies for successful enrollment of patients.

Cited by 10 publications

References 16 publications

Knowledge and attitudes regarding medical research studies among patients with breast cancer and gynecological diseases

Knowledge and attitudes regarding medical research studies among patients with breast cancer and gynecological diseases

<p>Factors Influencing Participation Of Healthy Volunteers In Clinical Trials: Findings From A Cross-Sectional Study In Delhi, North India</p>

Bereitschaft von Patienten zum Einschluss in klinische Studien

Contact Info

Product

Resources

About