Motivational and neurocognitive deficits are central to the prediction of longitudinal functional outcome in schizophrenia

Abstract

Both motivational and neurocognitive deficits independently contribute to longitudinal functional outcomes assessed 1 year later among patients with schizophrenia. Both of these domains of psychopathology impede functional recovery; hence, it follows that treatments ameliorating each of these symptoms should promote community functioning among individuals with schizophrenia.

Social anxiety disorder in recent onset schizophrenia spectrum disorders: The relation with symptomatology, anxiety, and social rank

“…Additionally, a key component of psychological models of SAD is the propensity to attend to and reflect upon how one is perceived by others, and this focus may similarly exist in the SZþ group and compensate for the attention deficits often observed in people with schizophrenia. Recently, research has highlighted the importance of cognition in schizophrenia, finding that not only is cognition affected in the premorbid phase (Fuller et al, 2002;Van Oel et al, 2002;Reichenberg et al, 2010) but also that cognitive symptoms are among the best predictors of social and community functioning in schizophrenia (Tyson et al, 2008;Fett et al, 2011;Fervaha et al, 2014). In fact, some have even called for a shift of focus to schizophrenia as a cognitive illness (Kahn and Keefe, 2013).…”

Working Memory Deficit as a Risk Factor for Severe Apathy in Schizophrenia: A 1-Year Longitudinal Study

“…Apathy is a transnosographic psychopathological state affecting 53% of individuals with a diagnosis of schizophrenia, 1 and contributing to poorer functioning 2 and subjective quality of life in both first episode and chronic schizophrenia. [3][4][5] Apathy, considered as a core component of negative symptoms 6,7 can be defined as a quantitative reduction of voluntary goal-directed behaviors, 8 and outside the schizophrenia literature has been the subject of fundamental research interest in neurological disorders such as Parkinson disease, brain injury and Alzheimer Disease.…”

A preliminary examination of the validity and reliability of a new brief rating scale for symptom domains of psychosis: Brief Evaluation of Psychosis Symptom Domains (BE-PSD)

“…Of note, bizarre behavior was not included as disorganized symptoms in this scale since only symptoms related to thinking/cognitive process (i.e., P2, conceptual disorganization; N5, difficulty in abstract thinking; and G11, poor attention) were included in the consensus five-factor model (Wallwork et al, 2012). Negative symptoms consist of two components, diminished emotional expression and avolition, in line with DSM-5 (American Psychiatric Association, 2013) and findings from factor analytic studies of negative symptoms using the PANSS (Fervaha et al, 2014;Liemburg et al, 2013). Manic symptoms were included as the scale was designed to be used not only for schizophrenia spectrum disorders but also other forms of psychosis such as bipolar disorder.…”