Mental pathology and violence have been studied by the scientific community, a topic that is sometimes perceived as controversial, partly due to the prevailing stigma around psychiatric disorders. In this project, all those factors concomitant with psychotic pathologies and ‘Cluster B’ antisocial disorders, which could interfere with the commission of violent actions, and their maximum expression, the homicide, are addressed from a comprehensive psychological perspective. To this end, a rigorous methodological selection of 15 high‐impact articles has been carried out, from which the results have been extracted and compared in this systematic review. The findings obtained revolve around the importance of adherence to treatment, the therapeutic alliance, the absence of toxic consumption, and concomitance with other mental pathologies, taking into account the idiosyncratic differences of the subjects, as well as between the pathologies and diagnoses described, always maintaining the comparison between said disorders, and with the population in absence of pathology.