2023
DOI: 10.1371/journal.pcbi.1011606
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Motoneuron-driven computational muscle modelling with motor unit resolution and subject-specific musculoskeletal anatomy

Arnault H. Caillet,
Andrew T. M. Phillips,
Dario Farina
et al.

Abstract: The computational simulation of human voluntary muscle contraction is possible with EMG-driven Hill-type models of whole muscles. Despite impactful applications in numerous fields, the neuromechanical information and the physiological accuracy such models provide remain limited because of multiscale simplifications that limit comprehensive description of muscle internal dynamics during contraction. We addressed this limitation by developing a novel motoneuron-driven neuromuscular model, that describes the forc… Show more

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Cited by 11 publications
(1 citation statement)
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“…The properties of the motor units in the two models are initialised following the rules below. In both models, the motor unit size (number of muscle fibres within each unit) is proportional to the amplitude of the motor unit twitch force [ 16 , 30 ], and the summation of the motor unit sizes meets the expected total number of fibres in one muscle ( Eq 1 ). In the classical model, the peak twitch force is exponentially distributed while in the LIF-based model, the twitches are distributed following the linear-exponential function in Eq 2 .…”
Section: Methodsmentioning
confidence: 99%
“…The properties of the motor units in the two models are initialised following the rules below. In both models, the motor unit size (number of muscle fibres within each unit) is proportional to the amplitude of the motor unit twitch force [ 16 , 30 ], and the summation of the motor unit sizes meets the expected total number of fibres in one muscle ( Eq 1 ). In the classical model, the peak twitch force is exponentially distributed while in the LIF-based model, the twitches are distributed following the linear-exponential function in Eq 2 .…”
Section: Methodsmentioning
confidence: 99%