Motor Activity of the Distal Ileum and Ileocecal Sphincter and Its Relation to the Region’s Function

Quigley, Eamonn Martin

doi:10.1159/000171199

Cited by 11 publications

(8 citation statements)

References 37 publications

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“…The tone was, however, considerably low er than that found in the human oesophagogastric [17] and internal anal junctions [18] in vitro, and is similar to that found in the human choledochoduodenal junctional region [17], In the ICJ, low muscular tone may be suffi cient to influence the motility of the junction without causing enough constriction of the lumen to produce a high-pressure zone on manometry. As in other sphincteric regions, structural features are important in determining the flow of contents, but the commonly observed papillary appearance of the ICJ on colonoscopy may suggest some degree of muscular activity as this is lost post-mortem [5]. The presence of a small degree of tone in the ICJ strips allowed relaxation to EFS to be easily detected, whereas in strips from either side of the junction, tone had to be raised for relaxation to EFS to become obvious.…”

Section: Myogenic Controlmentioning

confidence: 99%

“…It is not clear whether the separa tion of small and large intestinal contents is due to a val vular or a muscular (myogenic) mechanism or a combina tion of both, and considerable species variation has been reported [2][3][4][5], Evidence is accumulating that sphincteric muscle may differ from non-sphincteric muscle in innervation, in tone and/or response to stretch, and in response to various drugs [6], A localised region of muscle at the human ICJ has been reported to contract in vitro in response to adrenaline [7], differentiating it from muscle either side of the junction [8]. To characterise further the drug re sponses of this region of the digestive tract and throw light on its innervation and control we have re-examined strips from the human ICJ and subjected them to electrical-field stimulation (EFS).…”

Section: Introductionmentioning

confidence: 99%

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Control of the Human lleocaecal Junction: An in vitro Analysis of Adrenergic and Non-Adrenergic Non-Cholinergic Mechanisms

McKirdy

Marshall²,

Taylor³

1993

Digestion

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Circular muscle strips from the human lleocaecal junction developed myogenic tone (sustained resting tension) in vitro and showed an obvious component of relaxation in response to electrical field stimulation. These features are considered typical of sphincteric muscle because circular muscle strips from terminal ileum 1-2 cm proximal to the junction and from the caecum or ascending colon 1-2 cm distal to the junction developed little or no tone and showed predominantly contractile responses to electrical-field stimulation. In 18 out of 29 specimens, junctional strips showed excitatory responses to adrenaline or noradrenaline. The relaxation of junctional strips was non-adrenergic non-cholinergic (NANC) in nature. Nitric oxide appears to be involved in the NANC relaxation.

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Section: Myogenic Controlmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Control of the Human lleocaecal Junction: An in vitro Analysis of Adrenergic and Non-Adrenergic Non-Cholinergic Mechanisms

McKirdy

Marshall²,

Taylor³

1993

Digestion

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“…Indeed, these findings suggest that with respect to the longitudinal profile of small intestinal motor patterns, the rat resembles the human more closely than does the dog, the more usual in vivo model of small intestinal motility. The sharp fall in incidence of phase 111 complexes and increase in irregular spike activity (phase 11) is a feature of the rat and human (11,13) but not of the canine distal small intestine (12,17,22).…”

Section: Discussionmentioning

confidence: 96%

“…For fasted recordings, animals were fasted for at least 12 hours overnight. Following attachment to the perfusion system or electrical connector, studies were continued in the fasting state for at least 2 hours while the animal was free to move around in a 17.5 x 24.5 x 18 cm noninsulated cage. Studies were performed at weekly intervals over a 4-week study period on each animal.…”

Section: Intraluminal Pressure and Myoelectkical Recordingsmentioning

confidence: 99%

Studies of Small Intestinal Myoelectrical Activity and Intraluminal Pressure Changes in the Unrestrained Conscious Rat

Arouni

Lof

Jacobs

et al. 1991

Neurogastroenterology Motil

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Our aim was to develop and validate a methodology to permit chronic recordings of small intestinal intraluminal pressure changes in the conscious rat and thereby to study regional variations in motor activity. A low‐flow (0.014 cc/min) perfusion system permitted reliable intraluminal pressure recordings at four sites along the small intestine from unrestrained animals. Comparison of overall patterns of fasted and fed motor activity and the various parameters of the migrating motor complex (MMC) from these recordings with those obtained from another group of animals prepared with serosal electrodes provided similar results in the proximal small intestine (MMC frequency 3.4 ± 0.5 vs. 3.9 ± 0.3 cycles/h, phase II duration 3.8 ± 0.7 vs. 4.7 ± 0.4 min, and phase III duration 4.0 ± 0.2 vs. 3.5 ± 0.2 min for duodenal catheters vs. electrodes, all NS). However, the distal deal phase II was considerably shorter in catheter than electrode recordings (6.0 ± 0.8 vs. 15.7 ± 2.4 min, p < 0.0001). Both methodologies confirmed significant regional variations in small intestinal motor parameters: the incidence of interdigestive myoelectrical complex (IDMEC) cycles was lower and phase II of the IDMEC was considerably prolonged in the distal Hewn. In summary, a system to permit chronic recordings of small intestinal intraluminal pressure has been developed and validated by comparison to myoelectrical recordings. Motor specialization was evident in the rat distal ileum.

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“…which contributes to the sphincteric tone. 12 Harvest of a patch of cecum disrupts this mechanism and could potentially increase the aspiration rate. Patients undergoing reconstruction with the ileocecal patch flap did not show an increased incidence of aspiration compared with those undergoing free ileocolon flap surgery.…”

Section: Discussionmentioning

confidence: 99%

Voice Reconstruction with Free Ileocolon Flap Transfer: Implications for the Lower Respiratory Tract

Rampazzo

Gharb

Spilimbergo

et al. 2011

Plastic and Reconstructive Surgery

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Reconstruction with the free ileocolon flap was shown to be a possible therapeutic option when considering the consequences on the lower respiratory tract. Aspiration was the main complication and was avoided by internal plication of the valve and by reduction of the ileocecal angle. Awareness of the nature of the bacterial flora colonizing the trachea and voice tube could be helpful in guiding the empirical antibiotic therapy in case of infection.

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Motor Activity of the Distal Ileum and Ileocecal Sphincter and Its Relation to the Region’s Function

Cited by 11 publications

References 37 publications

Control of the Human lleocaecal Junction: An in vitro Analysis of Adrenergic and Non-Adrenergic Non-Cholinergic Mechanisms

Control of the Human lleocaecal Junction: An in vitro Analysis of Adrenergic and Non-Adrenergic Non-Cholinergic Mechanisms

Studies of Small Intestinal Myoelectrical Activity and Intraluminal Pressure Changes in the Unrestrained Conscious Rat

Voice Reconstruction with Free Ileocolon Flap Transfer: Implications for the Lower Respiratory Tract

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