Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease

Foster, Erin R.; Black, Kevin J.; Antenor-Dorsey, Jo Ann V.; Perlmutter, Joel S.; Hershey, Tamara

doi:10.1016/j.bandc.2007.10.002

Cited by 42 publications

(33 citation statements)

References 52 publications

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“…Three studies disclosed a worse BVRT-performance for LPD patients (Amick et al 2006a;Starkstein et al 1987;Tomer et al 1993), whereas two studies reported no differences between the groups (Mohr et al 1992;Starkstein et al 1987). A recent study also found a worse performance in LPD patients on a spatial delayed response task (Foster et al 2008). Taken together, seven out of thirteen studies investigating visuospatial memory in asymmetric PD reported no differences between the groups, five found a worse performance for the LPD group, and one study showed a disadvantage for the RPD group.…”

Section: ) Memorymentioning

confidence: 87%

“…Among these, there are further differences in the cutoff-values that were applied. In six studies, the difference between the left and the right score was used (Agniel et al 1991;Cubo et al 2010;Ebersbach et al 1996;Huber et al 1992;Nys et al 2010;Riklan et al 1990), six studies used the ratio between the left-and the right-sided scores (3:1 or 2:1) (Harris et al 2003;Lee et al 2001a, b;Spicer et al 1988;Starkstein and Leiguarda 1993;Starkstein et al 1987) and five other studies used a lateralization index of the symptom severity scores on the left side and on right side (difference/sum) (Clair et al 1998;Dominey et al 1995;Finali et al 1995;Foster et al 2008;Holtgraves et al 2010). Two studies only included patients with exclusively unilateral symptoms (Hietanen and Teräväinen 1989;Huber et al 1989Huber et al , 1989, whereas most of the studies tested patients with bilateral asymmetric symptoms.…”

Section: Methodological Issuesmentioning

confidence: 99%

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Cognitive Differences Between Patients with Left-sided and Right-sided Parkinson’s Disease. A Review

et al. 2011

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At disease onset, patients with Parkinson's disease (PD) typically report one side of the body to be more affected than the other. Previous studies have reported that this motor symptom asymmetry is associated with asymmetric dopaminergic degeneration in the brain. Research on the cognitive repercussions of this asymmetric degeneration has yielded inconsistent results. Here, we review studies that reported on the cognitive performance of patients with left-sided (LPD) or right-sided (RPD) motor symptom predominance. We present evidence that patients with RPD typically experience problems with language-related tasks and verbal memory, whereas patients with LPD more often perform worse on tasks of spatial attention, visuospatial orienting and memory and mental imagery. In general, no differences were found between both groups on tasks measuring attention and executive function. The association between motor asymmetry and cognitive performance indicates that PD does not lead to one typical cognitive profile. The effect of symptom laterality on the cognitive complaints should be considered in the assessment and treatment of each individual patient.

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Section: ) Memorymentioning

confidence: 87%

Section: Methodological Issuesmentioning

confidence: 99%

Cognitive Differences Between Patients with Left-sided and Right-sided Parkinson’s Disease. A Review

et al. 2011

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“…The substantia nigra was identified on the 3 T turbo spin-echo sequence (Foster et al, 2007). This region included both the pars compacta and the pars reticulata.…”

Section: Image Analysismentioning

confidence: 99%

Cerebral Mitochondrial Metabolism in Early Parkinson's Disease

Videen

Markham

Black

et al. 2008

J Cereb Blood Flow Metab

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Abnormal cerebral energy metabolism owing to dysfunction of mitochondrial electron transport has been implicated in the pathogenesis of Parkinson's disease (PD). However, in vivo data of mitochondrial dysfunction have been inconsistent. We directly investigated mitochondrial oxidative metabolism in vivo in 12 patients with early, never-medicated PD and 12 age-matched normal controls by combined measurements of the cerebral metabolic rate of oxygen (CMRO 2 ) and the cerebral metabolic rate of glucose (CMRglc) with positron emission tomography. The primary analysis showed a statistically significant 24% increase in bihemispheric CMRO 2 and no change in CMRO 2 /CMRglc. These findings are inconsistent with a defect in mitochondrial oxidative phosphorylation owing to reduced activity of the mitochondrial electron transport system (ETS). Because PD symptoms were already manifest, deficient energy production owing to a reduced activity of the mitochondrial ETS cannot be a primary mechanism of neuronal death in early PD. Alternatively, this general increase in CMRO 2 could be due not to an increased metabolic demand but to an uncoupling of ATP production from oxidation in the terminal stage of oxidative phosphorylation. Whether this is the case in early PD and whether it is important in the pathogenesis of PD will require further study.

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“…Consistent with these visual deficits in LOPD, deficits in visuospatial ability/attention (Norton, Jaywant, Gallart‐Palau, & Cronin‐Golomb, 2015; Poletti et al., 2013) and spatial planning (Cheesman et al., 2005) have been found. Interestingly, a deficit in spatial memory was shown to be associated with smaller substantia nigra volume (using MRI) in LOPD (Foster, Black, Antenor‐Dorsey, Perlmutter, & Hershey, 2008; Those with LOPD have shown significant impairment of working memory on the Digit Span Backward (DSB) task, which was associated with significantly greater depression in one study (Foster et al., 2013) and significantly greater anxiety in another study (Foster et al., 2010). Furthermore, those with LOPD show a deficit in mental rotation related to object‐view (Cronin‐Golomb, 2010; Lee, Harris, & Calvert, 1998).…”

Section: Introductionmentioning

confidence: 99%

Side‐of‐onset of Parkinson's disease in relation to neuropsychological measures

et al. 2016

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BackgroundParkinson's disease (PD) usually emerges with a unilateral side‐of‐onset (left‐onset: LOPD; right‐onset: ROPD; Marinus & van Hilten, 2015) due to an asymmetrical degeneration of striatal dopaminergic neurons (Donnemiller et al., Brain, 135, 2012, 3348). This has led to a body of research exploring the cognitive, neuropsychological, and clinical differences between LOPD and ROPD (e.g., Verreyt et al., Neuropsychology Review, 21, 2011, 405).MethodsThirty ROPD and 14 LOPD cases were drawn from a Boston clinic specializing in PD. Various cognitive and neuropsychological measures were used in an attempt to discover if there were indeed any differences between LOPD and ROPD in this cohort.ResultsFor LOPD, duration of illness was found to be significantly greater than that of ROPD. However, further testing was able to confirm that despite this difference, it was not the cause of the other significant differences found. Furthermore, this increased duration was consistent with a previous study (Munhoz et al., Parkinsonism and Related Disorders, 19, 2013, 77). Performance on the Digit Span Backward (DSB) was found to be significantly poorer in LOPD than ROPD, suggesting compromised executive function in LOPD. Additionally, LOPD had significantly greater anxiety on the DASS Anxiety scales than ROPD. However, unlike Foster et al (Cognitive and Behavioral Neurology, 23, 2010, 4), this increased anxiety could not account for the poorer performance on the DSB for LOPD. Finally, ROPD had significantly greater magical ideation than LOPD, which can be explained by the theory put forth by Brugger and Graves (European Archives of Psychiatry, 247, 1997, 55).ConclusionClear and significant differences between LOPD and ROPD were found within our cohort. LOPD showed greater impairment of working memory, greater anxiety, and greater duration of illness—all independent of one another; whereas, those with ROPD had greater magical ideation, also independent of any other variables.

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Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease

Cited by 42 publications

References 52 publications

Cognitive Differences Between Patients with Left-sided and Right-sided Parkinson’s Disease. A Review

Cognitive Differences Between Patients with Left-sided and Right-sided Parkinson’s Disease. A Review

Cerebral Mitochondrial Metabolism in Early Parkinson's Disease

Side‐of‐onset of Parkinson's disease in relation to neuropsychological measures

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