Motor asymmetry over time in Parkinson’s disease

Miller-Patterson, Cameron; Buesa, Richard; McLaughlin, Nicole; Jones, Richard N.; Akbar, Umer; Friedman, Joseph H.

doi:10.1016/j.jns.2018.08.001

Cited by 44 publications

(36 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on previous reports [7,10,11,14], we hypothesise that in moderate PD, the decline of striatal DAT density in the ipsilateral side is greater than in the contralateral side, and that the asymmetry of striatal DAT degeneration becomes less marked over 19 months. We expect the progress of clinical scores to occur in a similar pattern between the clinically most and least affected body sides.…”

Section: Introductionmentioning

confidence: 77%

“…With respect to motor symptoms, a number of studies evaluating PD patients over a wide range of disease durations demonstrate retention of asymmetry over many years [10,11]. However, two interesting studies [26,27] using multiple regression analyses and focussing on the earlier stages of PD showed that shorter disease duration and younger age at onset correlate with higher motor symptom asymmetry.…”

Section: Discussionmentioning

confidence: 99%

“…PET studies show that the degree of asymmetry in striatal dopamine transporter (DAT) tracer binding becomes less prominent over the course of the disease [7,9]. However, clinical studies indicate that the motor symptoms retain asymmetry over many years [10,11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Parkinson’s disease laterality: a 11C-PE2I PET imaging study

et al. 2020

View full text Add to dashboard Cite

Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson's disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11 C-PE2I non-displaceable binding potential (BP ND) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal 11 C-PE2I BP ND over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.

show abstract

Section: Introductionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Parkinson’s disease laterality: a 11C-PE2I PET imaging study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Parkinson's disease (PD), which is the second most common progressive neurodegenerative disease, results in motor and non-motor dysfunctions caused by the degeneration of dopamine-producing cells of the substantia nigra and other brain regions [1,2]. Clinical motor symptoms include bradykinesia, tremor, rigidity, freezing of gait, and instability of posture and gait [3][4][5][6]. Some of the common manifestations of PD that affect gait and posture are stooped posture and shuffling of gait, increases in gait asymmetry and double support time, reductions in step length and walking speed, impairments in postural responses to perturbations, and increases in variability of step/stride time as well as step/stride length [7].…”

Section: Introductionmentioning

confidence: 99%

Cueing Paradigms to Improve Gait and Posture in Parkinson’s Disease: A Narrative Review

Muthukrishnan

Abbas

Shill

et al. 2019

Sensors

View full text Add to dashboard Cite

Progressive gait dysfunction is one of the primary motor symptoms in people with Parkinson's disease (PD). It is generally expressed as reduced step length and gait speed and as increased variability in step time and step length. People with PD also exhibit stooped posture which disrupts gait and impedes social interaction. The gait and posture impairments are usually resistant to the pharmacological treatment, worsen as the disease progresses, increase the likelihood of falls, and result in higher rates of hospitalization and mortality. These impairments may be caused by perceptual deficiencies (poor spatial awareness and loss of temporal rhythmicity) due to the disruptions in processing intrinsic information related to movement initiation and execution which can result in misperceptions of the actual effort required to perform a desired movement and maintain a stable posture. Consequently, people with PD often depend on external cues during execution of motor tasks. Numerous studies involving open-loop cues have shown improvements in gait and freezing of gait (FoG) in people with PD. However, the benefits of cueing may be limited, since cues are provided in a consistent/rhythmic manner irrespective of how well a person follows them. This limitation can be addressed by providing feedback in real-time to the user about performance (closed-loop cueing) which may help to improve movement patterns. Some studies that used closed-loop cueing observed improvements in gait and posture in PD, but the treadmill-based setup in a laboratory would not be accessible outside of a research setting, and the skills learned may not readily and completely transfer to overground locomotion in the community. Technologies suitable for cueing outside of laboratory environments could facilitate movement practice during daily activities at home or in the community and could strongly reinforce movement patterns and improve clinical outcomes. This narrative review presents an overview of cueing paradigms that have been utilized to improve gait and posture in people with PD and recommends development of closed-loop wearable systems that can be used at home or in the community to improve gait and posture in PD.

show abstract

“…Parkinson’s disease (PD) is one of the most common neurodegenerative diseases; resting tremor, akinesia and rigidity are the typical and core symptoms in its clinical stage [ 1 , 2 ]. Studies with large samples have shown that more than half of PD patients have an evident asymmetry of motor symptoms [ 3 – 5 ], and the asymmetry will persist along the disease trajectory [ 6 , 7 ], which is important supportive evidence for PD diagnosis [ 2 , 4 ]. However, the pathogenesis underlying such motor asymmetry in PD is still enigmatic.…”

Section: Introductionmentioning

confidence: 99%

Asymmetrical nigral iron accumulation in Parkinson’s disease with motor asymmetry: an explorative, longitudinal and test-retest study

Guan

Guo

Zhou

et al. 2020

Aging

View full text Add to dashboard Cite

Parkinson’s disease (PD) is commonly characterized by asymmetrical motor impairment. This study aimed to clarify the iron distributions in PD patients with significant motor asymmetry and their longitudinal alterations. This study included 123 PD patients and 121 normal controls. Thirty-eight PD patients were revisited. PD patients with significant motor asymmetry were identified by using an objective criterion. Inter-group, inter-hemisphere and inter-visit differences of regional tissue susceptibility were analyzed. Iron accumulation in dominantly and non-dominantly affected substantia nigra (SN) were observed in PD patients with motor asymmetry compared with normal controls (p < 0.005, Bonferroni corrected). Iron accumulation in the dominantly affected SN was significantly higher than that in the non-dominantly affected SN (p < 0.01, Bonferroni corrected). After follow-up, time effect on the iron content in SN was observed, directing to decrease in PD patients with motor asymmetry without hemispherical difference (p < 0.05). In conclusion, asymmetrical iron accumulation in SN was associated with the motor asymmetry in PD at baseline, while along the disease evolution iron content in SN became longitudinally decreased. All these findings provide new evidence for PD pathogenesis that the abnormal iron metabolism in SN is complicated and not always unidirectional.

show abstract

Motor asymmetry over time in Parkinson’s disease

Cited by 44 publications

References 10 publications

Parkinson’s disease laterality: a 11C-PE2I PET imaging study

Parkinson’s disease laterality: a 11C-PE2I PET imaging study

Cueing Paradigms to Improve Gait and Posture in Parkinson’s Disease: A Narrative Review

Asymmetrical nigral iron accumulation in Parkinson’s disease with motor asymmetry: an explorative, longitudinal and test-retest study

Contact Info

Product

Resources

About