Motor band sign or biomarker

Ghaderi, Sadegh; Mohammadi, Sana

doi:10.1002/ird3.43

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Recent advances in post-processing neuroimaging methods have provided a novel tool for assessing brain iron concentration ( Ghaderi et al, 2023 ). The relevance of iron accumulation in AD pathology warrants a sophisticated approach to its quantification, which is now feasible with advancements in magnetic resonance imaging (MRI) technologies ( Ghaderi and Mohammadi, 2023 ; Mohammadi and Ghaderi, 2023 ), particularly quantitative susceptibility mapping (QSM) ( Ghaderi et al, 2023 ). QSM provides quantitative measurements of tissue iron content, overcoming limitations of other MRI techniques such as R2* and phase imaging for quantifying iron ( Liu et al, 2015 ; Ravanfar et al, 2021 ; Ghaderi et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Iron quantification in basal ganglia: quantitative susceptibility mapping as a potential biomarker for Alzheimer’s disease – a systematic review and meta-analysis

Ghaderi,

Mohammadi,

Nezhad

et al. 2024

Front. Neurosci.

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IntroductionAlzheimer’s disease (AD), characterized by distinctive pathologies such as amyloid-β plaques and tau tangles, also involves deregulation of iron homeostasis, which may accelerate neurodegeneration. This meta-analysis evaluated the use of quantitative susceptibility mapping (QSM) to detect iron accumulation in the deep gray matter (DGM) of the basal ganglia in AD, contributing to a better understanding of AD progression, and potentially leading to new diagnostic and therapeutic approaches.MethodsUsing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically searched the PubMed, Scopus, Web of Sciences, and Google Scholar databases up to October 2023 for studies employing QSM in AD research. Eligibility criteria were based on the PECO framework, and we included studies assessing alterations in magnetic susceptibility indicative of iron accumulation in the DGM of patients with AD. After initial screening and quality assessment using the Newcastle-Ottawa Scale, a meta-analysis was conducted to compare iron levels between patients with AD and healthy controls (HCs) using a random-effects model.ResultsThe meta-analysis included nine studies comprising 267 patients with AD and 272 HCs. There were significantly higher QSM values, indicating greater iron deposition, in the putamen (standardized mean difference (SMD) = 1.23; 95% CI: 0.62 to 1.84; p = 0.00), globus pallidus (SMD = 0.79; 95% CI: 0.07 to 1.52; p = 0.03), and caudate nucleus (SMD = 0.72; 95% CI: 0.39 to 1.06; p = 0.00) of AD patients compared to HCs. However, no significant differences were found in the thalamus (SMD = 1.00; 95% CI: −0.42 to 2.43; p = 0.17). The sensitivity analysis indicated that no single study impacted the overall results. Age was identified as a major contributor to heterogeneity across all basal ganglia nuclei in subgroup analysis. Older age (>69 years) and lower male percentage (≤30%) were associated with greater putamen iron increase in patients with AD.ConclusionThe study suggests that excessive iron deposition is linked to the basal ganglia in AD, especially the putamen. The study underscores the complex nature of AD pathology and the accumulation of iron, influenced by age, sex, and regional differences, necessitating further research for a comprehensive understanding.

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Section: Introductionmentioning

confidence: 99%

Iron quantification in basal ganglia: quantitative susceptibility mapping as a potential biomarker for Alzheimer’s disease – a systematic review and meta-analysis

Ghaderi,

Mohammadi,

Nezhad

et al. 2024

Front. Neurosci.

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“…Magnetic resonance imaging (MRI) is a widely available and powerful tool for better neuroimaging visualization and has become an indispensable tool for evaluating and diagnosing the progression of neurodegenerative diseases (NDDs) [ 1 , 2 ]. Magnetic susceptibility (χ) is a property of a material that reflects its response to an external magnetic field [ 3 , 4 ]. Iron content, tissue microstructure and composition, and other factors have an impact on χ [ [5] , [6] , [7] ].…”

Section: Introductionmentioning

confidence: 99%

Parkinson's disease and Parkinsonism syndromes: Evaluating iron deposition in the putamen using magnetic susceptibility MRI techniques - A systematic review and literature analysis

Mohammadi,

Ghaderi

2024

Heliyon

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Quantitative susceptibility mapping as an early neuroimaging biomarker for amyotrophic lateral sclerosis: A review

Mohammadi,

Ghaderi,

Fatehi

2024

iRADIOLOGY

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Quantitative susceptibility mapping (QSM) is an advanced post‐processing technique in magnetic resonance imaging that offers precise measurements of tissue magnetic susceptibility with impressive spatial resolution and sensitivity. This review examines the potential of QSM as a biomarker for early detection and monitoring of amyotrophic lateral sclerosis (ALS). Since 2015, studies have consistently reported increased QSM values in the motor regions of individuals with ALS, indicating significant iron deposition. Iron accumulation is associated with dysfunction of the upper motor neurons and faster disease progression. Notably, increased QSM values were also observed in the critical subcortical areas responsible for motor function and cognitive control. However, standardizing optimized protocols, including background field removal algorithms, phase unwrapping approaches, and methods for final susceptibility map reconstruction, has the potential to enhance the consistency and reliability of QSM as an ALS biomarker. Overall, the current body of evidence strongly supports QSM in detecting iron dysregulation associated with neurodegeneration in both motor and extra‐motor regions in ALS. Furthermore, QSM's remarkable sensitivity to early pathological iron changes and its high specificity in distinguishing ALS positions make it a promising diagnostic and progression‐tracking biomarker.

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Motor band sign or biomarker

Cited by 3 publications

References 13 publications

Iron quantification in basal ganglia: quantitative susceptibility mapping as a potential biomarker for Alzheimer’s disease – a systematic review and meta-analysis

Iron quantification in basal ganglia: quantitative susceptibility mapping as a potential biomarker for Alzheimer’s disease – a systematic review and meta-analysis

Parkinson's disease and Parkinsonism syndromes: Evaluating iron deposition in the putamen using magnetic susceptibility MRI techniques - A systematic review and literature analysis

Quantitative susceptibility mapping as an early neuroimaging biomarker for amyotrophic lateral sclerosis: A review

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