Motor behaviour in infancy is associated with neurological, cognitive, and behavioural function of children born to parents with reduced fertility

Wu, Ying‐Chin; Heineman, Kirsten R.; Gemert, Sacha la Bastide‐van; Kuiper, Derk; Olivares, Machiel Drenth; Hadders‐Algra, Mijna

doi:10.1111/dmcn.14520

Cited by 16 publications

(21 citation statements)

References 30 publications

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“…The domain is composed of only 7 items (6 for non-walking infants) which mostly investigate the presence of tremors and non-fluent movements during the assessment. Unlike previously published data [14,15], the majority of infants in our study sample scored the same low value on this domain (75 points). Moreover, the IMP fluency at 5 months was poorly correlated to the presence of brain injury and showed no significant relation with the neurodevelopmental outcome.…”

Section: Discussioncontrasting

confidence: 84%

“…In 2011, they longitudinally assessed a group of preterm and full-term infants using the IMP at 4, 6, 10 and 12 months showing a high ability to predict CP at 18 months [14]. Recently, the same group demonstrated a clear relationship between developmental motor trajectories measured with the IMP and later outcome at school age [15]. These findings support the idea that the variability of an early motor repertoire could represent not only an early marker of major motor disorders but also of neurodevelopmental disorders as a whole.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, these studies mainly involved infants being at relatively low risk for NDD (e.g. children of parents with reduced fertility or term infants with no additional risk factors) [12,[14][15][16] raising the need to explore the relation between the IMP and outcome in high risk populations. Moreover, as neonatal brain ultrasound and MRI is becoming increasingly important in the prognosis of at-risk infants, the relation between the imaging findings and the IMP still needs to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Concurrent and predictive validity of the infant motor profile in infants at risk of neurodevelopmental disorders

et al. 2021

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Background Preterm infants and infants with perinatal brain injury show a higher incidence of neurodevelopmental disorders (NDD). The Infant Motor Profile (IMP) is a clinical assessment which evaluates the complexity of early motor behaviour. More data are needed to confirm its predictive ability and concurrent validity with other common and valid assessments such as the Alberta Infant Motor Scale (AIMS) and Prechtl’s General Movement Assessment (GMA). The present study aims to evaluate the concurrent validity of the IMP with the AIMS, to assess its association with the GMA, to evaluate how the IMP reflects the severity of the brain injury and to compare the ability of the IMP and the AIMS to predict an abnormal outcome in 5-month-old infants at risk of NDD. Methods 86 infants at risk of NDD were retrospectively recruited among the participants of two clinical trials. Preterm infants with or without perinatal brain injury and term infants with brain injury were assessed at 3 months corrected age (CA) using the GMA and at 5 months CA using the IMP and the AIMS. The neurodevelopmental outcome was established at 18 months. Results Results confirm a solid concurrent validity between the IMP Total Score and the AIMS (Spearman’s ρ 0.76; p < .001) and a significant association between IMP Total Score and the GMA. Unlike the AIMS, the IMP Total score accurately reflects the severity of neonatal brain injury (p < .001) and proves to be the strongest predictor of NDD (p < .001). The comparison of areas under receiver operating characteristic curves (AUC) confirms that the IMP Total score has the highest diagnostic accuracy at 5 months (AUC 0.92). For an optimal IMP Total Score cut-off value of 70, the assessment shows high sensitivity (93%) and specificity (81%) (PPV 84%; NPV 90%). Conclusions Early motor behaviour assessed with the IMP is strongly associated with middle-term neurodevelopmental outcome. The present study confirms the concurrent validity of the IMP with the AIMS, its association with the GMA and its ability to reflect brain lesion load, hence contributing to the construct validity of the assessment. Trial registration NCT01990183 and NCT03234959 (clinicaltrials.gov).

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Section: Discussioncontrasting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Concurrent and predictive validity of the infant motor profile in infants at risk of neurodevelopmental disorders

et al. 2021

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“…10 Recently, the same group demonstrated a clear relationship between developmental motor trajectories measured with IMP and later outcome at school age. 11 These findings support the idea that variability of early motor repertoire could represent not only an early marker of major motor disorders but also of neurodevelopmental disorders as a whole.…”

Section: Introductionsupporting

confidence: 75%

Concurrent and Predictive Validity of the Infant Motor Profile in Infants at Risk of Neurodevelopmental Disorders

Rizzi

Menici

Cioni

et al. 2020

Preprint

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Background: Preterm infants and infants with perinatal brain injury show higher incidence of neurodevelopmental disorders (NDD). The Infant Motor Profile (IMP) is a clinical assessment which evaluates the complexity of early motor behaviour. More data are needed to confirm its predictive ability and concurrent validity with other common and valid assessments such as the Alberta Infant Motor Profile (AIMS) and the Prechtl’s General Movement Assessment (GMA). The present study aims to evaluate the concurrent validity of IMP with AIMS, to assess its association with GMA, to evaluate how IMP reflects the severity of the brain injury and to compare the ability of IMP and AIMS to predict abnormal outcome in 5-months infants at risk of NDD.Methods: 86 infants at risk of NDD were retrospectively recruited among the participants of two clinical trials. Preterm infants with or without perinatal brain injury and term infants with brain injury were assessed at 3 months corrected age (CA) using GMA and at 5 months CA using IMP and AIMS. Neurodevelopmental outcome was established at 18 months.Results: Results confirm a solid concurrent validity between IMP and AIMS (Spearman’s ρ 0.76; p<.001) and significant association between IMP and GMA. Unlike AIMS, IMP Total score accurately reflects the severity of neonatal brain injury (p<.001) and results to be the strongest predictor of NDD (p<.001). Confrontation of areas under receiver operating characteristic curves (AUC) confirms that IMP Total score has the highest diagnostic accuracy at 5 months (AUC 0.92). For an optimal IMP cut-off value of 70, the assessment shows high sensitivity (93%) and specificity (81%) (PPV 84%; NPV 90%).Conclusions: Early motor behaviour assessed with IMP is strongly associated with middle-term neurodevelopmental outcome. The present study confirms the concurrent validity of IMP with AIMS, its association with GMA and its ability to reflect brain lesion load contributing to the construct validity of the assessment.Trial registration: NCT01990183 and NCT03234959 (clinicaltrials.gov)

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“…They showed that low IMP scores predicted CP well, one study reported areas under the receiver-operating characteristic curves: 0.89–0.99 [ 109 ], the other a sensitivity of 93% and a specificity of 81% [ 110 ]. Low IMP scores also have been associated with lower IQ scores at preschool and school age [ 111 , 112 ].…”

Section: Early Detection Of Developmental Disordersmentioning

confidence: 99%

Early Diagnostics and Early Intervention in Neurodevelopmental Disorders—Age-Dependent Challenges and Opportunities

Hadders‐Algra

2021

JCM

Self Cite

115

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This review discusses early diagnostics and early intervention in developmental disorders in the light of brain development. The best instruments for early detection of cerebral palsy (CP) with or without intellectual disability are neonatal magnetic resonance imaging, general movements assessment at 2–4 months and from 2–4 months onwards, the Hammersmith Infant Neurological Examination and Standardized Infant NeuroDevelopmental Assessment. Early detection of autism spectrum disorders (ASD) is difficult; its first signs emerge at the end of the first year. Prediction with the Modified Checklist for Autism in Toddlers and Infant Toddler Checklist is possible to some extent and improves during the second year, especially in children at familial risk of ASD. Thus, prediction improves substantially when transient brain structures have been replaced by permanent circuitries. At around 3 months the cortical subplate has dissolved in primary motor and sensory cortices; around 12 months the cortical subplate in prefrontal and parieto-temporal cortices and cerebellar external granular layer have disappeared. This review stresses that families are pivotal in early intervention. It summarizes evidence on the effectiveness of early intervention in medically fragile neonates, infants at low to moderate risk, infants with or at high risk of CP and with or at high risk of ASD.

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Motor behaviour in infancy is associated with neurological, cognitive, and behavioural function of children born to parents with reduced fertility

Cited by 16 publications

References 30 publications

Concurrent and predictive validity of the infant motor profile in infants at risk of neurodevelopmental disorders

Concurrent and predictive validity of the infant motor profile in infants at risk of neurodevelopmental disorders

Concurrent and Predictive Validity of the Infant Motor Profile in Infants at Risk of Neurodevelopmental Disorders

Early Diagnostics and Early Intervention in Neurodevelopmental Disorders—Age-Dependent Challenges and Opportunities

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