Motor cortical excitability behavior in chronic spinal cord injury neuropathic pain individuals submitted to transcranial direct current stimulation—case reports

Carvalho, Victor Gomide; Almeida, Rodrigo Lanna de; Boechat-Barros, Raphael

doi:10.1038/s41394-020-00355-5

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Furthermore, tDCS has no impact on pain thresholds and mechanical detection in healthy individuals [93]. However, the analgesic response to tDCS depends on many factors; hence, it is not effective in all patients with neuropathic pain [94]. The mechanisms underlying direct tDCS-induced analgesia are not completely understood; however, the effects may not only be related to increased or decreased neuronal firing rates as reports suggest the engagement of endorphins [95,96] and, in addition to modulation of glutamatergic and GABAergic balance [97], the alteration of certain neuromodulators such as dopamine [98].…”

Section: Non-invasive Brain Stimulationmentioning

confidence: 99%

Advances in targeting central sensitization and brain plasticity in chronic pain

Bazzari

2022

Egypt J Neurol Psychiatry Neurosurg

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Maladaptation in sensory neural plasticity of nociceptive pathways is associated with various types of chronic pain through central sensitization and remodeling of brain connectivity. Within this context, extensive research has been conducted to evaluate the mechanisms and efficacy of certain non-pharmacological pain treatment modalities. These include neurostimulation, virtual reality, cognitive therapy and rehabilitation. Here, we summarize the involved mechanisms and review novel findings in relation to nociceptive desensitization and modulation of plasticity for the management of intractable chronic pain and prevention of acute-to-chronic pain transition.

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Section: Non-invasive Brain Stimulationmentioning

confidence: 99%

Advances in targeting central sensitization and brain plasticity in chronic pain

Bazzari

2022

Egypt J Neurol Psychiatry Neurosurg

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“…Most studies that characterize CNP do not have a control group or are controlled with healthy individuals or central lesions without pain (18,(20)(21)(22)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51). Thus, there are limitations to understanding which alterations are characteristic of CNP or could be attributed to chronic pain in general (14,(52)(53)(54)(55), and its plastic changes (56,57), central and peripheral sensitization (58), or secondary to the CNS lesion itself (59)(60)(61)(62).…”

Section: Introductionmentioning

confidence: 99%

Dor neuropática central: caracterização clínica, psicofísica e neurofisiológica

Mendonça¹

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Transcutaneous spinal cord stimulation on motor function in patients with spinal cord injury: A meta-analysis

Shi,

Chen,

et al. 2024

NRE

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BACKGROUND: It has been suggested that transcutaneous spinal cord stimulation (SCS) is effective in the rehabilitation of patients with spinal cord injury (SCI). However, the evidence is mainly based on case reports. OBJECTIVE: To summarize the influence of transcutaneous SCS on extremity motor function of patients with SCI in a meta-analysis. METHODS: A systematic literature search was performed in electronic databases including PubMed, Cochrane library, Embase, Web of Science, Wanfang, and CNKI to obtain relevant randomized controlled trials (RCTs). A random-effects model was used to pool the results by incorporating the impact of the potential heterogeneity. The most recent database search was conducted on December 31, 2023. RESULTS: Six small-scale open-label or single-blind RCTs were included. Transcutaneous SCS on the basis of conventional rehabilitation could significantly improve limb strength (mean difference: 4.82, p = 0.004; I2 = 0%) and attenuate spasticity (MD: -0.40, p = 0.02; I2 = 0%). The upper-extremity motor function was not significantly affected (p = 0.75). However, transcutaneous SCS significantly improved mobility as indicated by walking speed (MD: 0.13 m/s, p = 0.009; I2 = 0%) and walking distance (standardized MD: 0.62, I2 = 0%). CONCLUSION: Transcutaneous SCS is effective in improving limb strength, spasticity and mobility of patients with SCI.

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Motor cortical excitability behavior in chronic spinal cord injury neuropathic pain individuals submitted to transcranial direct current stimulation—case reports

Cited by 3 publications

References 37 publications

Advances in targeting central sensitization and brain plasticity in chronic pain

Advances in targeting central sensitization and brain plasticity in chronic pain

Dor neuropática central: caracterização clínica, psicofísica e neurofisiológica

Transcutaneous spinal cord stimulation on motor function in patients with spinal cord injury: A meta-analysis

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