Motor Dysfunction and Sensorimotor Cortex Activation Changes in Schizophrenia: A Study with Functional Magnetic Resonance Imaging

Schröder, Johannes; Essig, Marco; Baudendistel, K.; Jähn, Thomas; Gerdsen, I.; Stockert, A.; Schad, Lothar R.; Knopp, Michael V.

doi:10.1006/nimg.1998.0387

Cited by 135 publications

(81 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data support the theory of a disturbed activation of subcortical regions in untreated patients with schizophrenia. 20,24 After treatment, subcortical activation did not differ significantly between the groups. Our data suggest that neuroleptic treatment reduces the ipsilateral overactivity of the pallidum to the level of healthy controls.…”

Section: Discussionmentioning

confidence: 87%

“…20,45 Other studies revealed evidence for a disturbed interhemispheric interaction. [20][21][22][23][24] Braus et al found a significantly lower number of activated voxels in schizophrenic patients treated with typical neuroleptic drugs compared to healthy controls and to patients treated with atypical neuroleptics. 25 In contrast to chronically ill patients, the same research group found no motor dysfunction in untreated firstepisode patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“…Several finger-tapping studies revealed activation differences under typical and atypical neuroleptic treatment. 14,[20][21][22][23][24][25][26][27][28] To date, subcortical regions have not been successfully explored in a larger sample of psychiatric inpatients. Recently, Moritz et al found that finger-tapping-induced brain activation has a shorter duration in basal ganglia than in the sensorimotor cortex.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Subcortical overactivation in untreated schizophrenic patients: A functional magnetic resonance image finger‐tapping study

Müller¹,

Röder²,

Schuierer

et al. 2002

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Functional magnetic resonance imaging (fMRI) is a well established, non-invasive technique for mapping the working brain. Yet imaging of subcortical regions has proven to be difficult. We studied 40 subjects performing an unilateral self-paced finger-tapping task. Patients with schizophrenia according to DSM-IV treated with olanzapine (n = 10) or haloperidol (n = 10) were compared to healthy controls (n = 10) and untreated patients (n = 10). Brainvoyager software was used for data-analyzing. All subjects showed highly significant activation in the contralateral sensorimotor area, the supplementary motor area and the ipsilateral cerebellum. In every investigated subject contralateral subcortical regions were also significantly activated (P < 0.001). Activation in ipsilateral pallidum was significantly higher in untreated patients compared with the other groups indicating an increase in subcortical coactivation. In addition, significant correlations were revealed within groups. This study emphasizes the possibility of investigating subcortical brain activation in patients with schizophrenia. The results of the present study outline the importance of further fMRI studies to investigate interindividual activation differences under different conditions especially focusing on basal ganglia.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Subcortical overactivation in untreated schizophrenic patients: A functional magnetic resonance image finger‐tapping study

Müller¹,

Röder²,

Schuierer

et al. 2002

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…We expect patients with schizophrenia to share a common, widespread deficit resulting in activation differences that transcend individual cognitive domains. This viewpoint is supported by the schizophrenia literature showing differences in almost every type of cognitive or sensory task studied [Bullmore et al, 1999;Calhoun et al, 2004b;Laurens et al, 2003;Manoach et al, 2000;Schroder et al, 1999]. In this context, the use of tasks that probe different functional domains is advantageous, and joint analyses of these data may even help us to unify better the diversity of findings present in previous work.…”

Section: Introductionmentioning

confidence: 75%

A method for multitask fMRI data fusion applied to schizophrenia

Calhoun

Adalı

Kiehl

et al. 2005

Human Brain Mapping

157

122

View full text Add to dashboard Cite

Abstract:It is becoming common to collect data from multiple functional magnetic resonance imaging (fMRI) paradigms on a single individual. The data from these experiments are typically analyzed separately and sometimes directly subtracted from one another on a voxel-by-voxel basis. These comparative approaches, although useful, do not directly attempt to examine potential commonalities between tasks and between voxels. To remedy this we propose a method to extract maximally spatially independent maps for each task that are "coupled" together by a shared loading parameter. We first compute an activation map for each task and each individual as "features," which are then used to perform joint independent component analysis (jICA) on the group data. We demonstrate our approach on a data set derived from healthy controls and schizophrenia patients, each of which carried out an auditory oddball task and a Sternberg working memory task. Our analysis approach revealed two interesting findings in the data that were missed with traditional analyses. First, consistent with our hypotheses, schizophrenia patients demonstrate "decreased" connectivity in a joint network including portions of regions implicated in two prevalent models of schizophrenia. A second finding is that for the voxels identified by the jICA analysis, the correlation between the two tasks was significantly higher in patients than in controls. This finding suggests that schizophrenia patients activate "more similarly" for both tasks than do controls. A possible synthesis of both findings is that patients are activating less, but also activating with a less-unique set of regions for these very different tasks. Both of the findings described support the claim that examination of joint activation across multiple tasks can enable new questions to be posed about fMRI data. Our approach can also be applied to data using more than two tasks. It thus provides a way to integrate and probe brain networks using a variety of tasks and may increase our understanding of coordinated brain networks and the impact of pathology upon them. Hum Brain Mapp 27:598-610, 2006.

show abstract

“…Additionally, in the uniparameter system, which is stimulated by sensorial stimulation (visual) such as photic stimulation and finger tapping and motor stimulation (finger motion), significantly increased regional cerebral blood volume was detected in the left occipital cortex and left caudate of schizophrenic subjects. Despite the sensorial asymmetry in this study, schizophrenia-associated motor abnormalities (decreased magnitude of fMRI) have been reported more frequently (Schröder J et al, 1999). Although, in some of the studies antipsychotic medication was thought to cause this lateralization asymmetry, neuropathological examination of postmortem motor cortex has revealed both abnormal and normal cortex (Braus et al, 2000).…”

Section: Functional Mri (F-mri) With Blood-oxygenation Level-dependenmentioning

confidence: 53%

Radiologic Imaging in Psychiatric Disorders in the Light of Recent Developments

Yıldırım¹

2011

Psychiatric Disorders - Worldwide Advances

View full text Add to dashboard Cite

Motor Dysfunction and Sensorimotor Cortex Activation Changes in Schizophrenia: A Study with Functional Magnetic Resonance Imaging

Cited by 135 publications

References 23 publications

Subcortical overactivation in untreated schizophrenic patients: A functional magnetic resonance image finger‐tapping study

Subcortical overactivation in untreated schizophrenic patients: A functional magnetic resonance image finger‐tapping study

A method for multitask fMRI data fusion applied to schizophrenia

Radiologic Imaging in Psychiatric Disorders in the Light of Recent Developments

Contact Info

Product

Resources

About