The benign epilepsy with spinous waves in the 1 central temporal region (BECT) is the one of the most common 2 epileptic syndromes in children, that seriously threaten the ner-3 vous system development of children. The most obvious feature of BECT is the existence of a large number of electroencephalogram 5 (EEG) spikes in the Rolandic area during the interictal period, 6 that is an important basis to assist neurologists in BECT diag-7 nosis. With this regard, the paper proposes a novel BECT spike 8 detection algorithm based on time domain EEG sequence features 9 and the long short-term memory (LSTM) neural network. Three time domain sequence features, that can obviously characterize the spikes of BECT, are extracted for EEG representation. The 12 synthetic minority oversampling technique (SMOTE) is applied to 13 address the spike imbalance issue in EEGs, and the bi-directional 14 LSTM (BiLSTM) is trained for spike detection. The algorithm is 15 evaluated using the EEG data of 15 BECT patients recorded from 16 the Children's Hospital, Zhejiang University School of Medicine 17 (CHZU). The experiment shows that the proposed algorithm can obtained an average of 88.54% F1 score, 92.04% sensitivity, and 19 85.75% precision, that generally outperforms several state-of-the-20 art spike detection methods.