Motor-induced brain activation in cortical, subcortical and cerebellar regions in schizophrenic inpatients. A whole brain fMRI fingertapping study

Müller, Jürgen; Röder, Christian; Schuierer, Gerhardt; Klein, Helmfried E.

doi:10.1016/s0278-5846(01)00271-8

Cited by 44 publications

(35 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Muller et al (2002) gave haloperidol or olanzapine during performance of a fingertapping motor task. They found that the blood oxygenation level dependent (BOLD) response in the putamen region of the striatum was significantly attenuated in patients treated with either haloperidol or olanzapine compared to untreated schizophrenic patients and healthy controls.…”

Section: Magnetic Resonance Imaging Studiesmentioning

confidence: 99%

Regional Differences in the Action of Antipsychotic Drugs: Implications for Cognitive Effects in Schizophrenic Patients

et al. 2010

View full text Add to dashboard Cite

Antipsychotic drugs (APDs) have been classified as typical or atypical based on their liability to produce extrapyramidal side effects: atypical APDs are less likely to produce extrapyamidal side effects at therapeutic doses. Evidence from immediate early gene immunohistochemical, electrophysiological, microdialysis, imaging, and behavioral studies suggests that typical APDs preferentially affect the nucleus accumbens (NAc) and the dorsal striatum while atypical APDs preferentially affect the NAc and medial prefrontal cortex (PFC). We review some of this evidence and then discuss studies that have employed cognitive tasks shown previously to depend on dorsal striatal or medial PFC function in schizophrenic patients treated with typical or atypical APDs. Results revealed that patients treated with typical APDs displayed deficits in cognitive tasks that depended on the dorsal striatum but not in tasks that depended on the medial PFC and that those treated with atypical APDs displayed deficits in cognitive tasks that depended on the medial PFC but not in cognitive tasks that depended on the dorsal striatum. These findings suggest that some of the cognitive deficits seen in schizophrenic patients may be related to the medications that are used to treat them.

show abstract

Section: Magnetic Resonance Imaging Studiesmentioning

confidence: 99%

Regional Differences in the Action of Antipsychotic Drugs: Implications for Cognitive Effects in Schizophrenic Patients

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Persons affected with SZ tend to be slow in initiating movements while performing a simple motor task as demonstrated by prolonged reaction time [8]. Previous neuropsycho-logical and functional imaging studies have also shown motor impairments in SZ [9–11]. Several reviews have focused on catatonia [12,13], abnormal involuntary movements and neurological soft signs (NSS; [14,15]), psychomotor slowing [16], motor deficits or neurological abnormalities in antipsychotic naive SZ patients [14,17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Functional magnetic resonance imaging (fMRI) using blood oxygenation level-dependent (BOLD) signal contrast is one of the most versatile and important tools to study non-invasive functional activation in the normal and diseased human brain [21]. A whole brain fMRI finger-tapping study reported that motor-induced cortical, subcortical, and cerebellar brain regions activation in healthy controls was significantly higher than in patients with SZ treated with neuroleptic drugs [9]. Another fMRI study demonstrated hypoactivation of supplementary motor area (SMA), left primary sensorimotor cortex, bilateral lateral premotor, and inferior parietal cortices during a sequential finger opposition task in akinetic neuroleptic-treated schizophrenic patients [22].…”

Section: Introductionmentioning

confidence: 99%

Motor function deficits in schizophrenia: an fMRI and VBM study

et al. 2014

View full text Add to dashboard Cite

Introduction To investigate whether the motor functional alterations in schizophrenia (SZ) are also associated with structural changes in the related brain areas using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM). Methods A sample of 14 right-handed SZ patients and 14 right-handed healthy control subjects matched for age, sex, and education were examined with structural high-resolution T1-weighted MRI; fMRI images were obtained during right index finger-tapping task in the same session. Results fMRI results showed reduced functional activation in the motor areas (contralateral precentral and postcentral gyrus) and ipsilateral cerebellum in SZ subjects as compared to healthy controls (n=14). VBM analysis also revealed reduced grey matter in motor areas and white matter reduction in cerebellum of SZ subjects as compared to controls. Conclusion The present study provides an evidence for a possible association between structural alterations in the motor cortex and disturbed functional activation in the motor areas in persons affected with SZ during a simple finger-tapping task.

show abstract

“…Several studies have shown sensory-motor abnormalities during finger movement tasks in schizophrenic subjects (Schröder et al, 1995;Mattay et al, 1997;Müller et al, 2002;Rogowska et al, 2004) but none has provided insight into neural plasticity over time. Our results emphasize the capacity of two different brain regions to support learning by tuning neural assemblies in an adaptive, dynamic manner.…”

Section: A1 To A2 Late Learning Pattern Changesmentioning

confidence: 99%

“…First, unmedicated, first-episode schizophrenics exhibit normal motor system integrity (Braus et al, 2000). Second, first-generation antipsychotics diminish activity in the primary motor cortex (Rogowska et al, 2004) and the supplementary motor cortex (SMA) (Braus et al, 1999), but second-generation antipsychotics are less likely to suppress the primary sensory-motor cortex (Braus et al, 1999;Müller et al, 2002) during a self-paced finger sequence task. Third, when engaged in a pronation/supination task schizophrenics taking clozapine exhibit diminished activity in the sensory-motor cortex.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Sequential neural changes during motor learning in schizophrenia

Rowland

Shadmehr

Kravitz

et al. 2008

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

Positron emission tomography (PET) was used to investigate differences in neural plasticity associated with learning a unique motor task in patients with schizophrenia and healthy volunteers. Working with a robotic manipulandum, subjects learned reaching movements in a force field. Visual cues were provided to guide the reaching movements. PET rCBF measures were acquired while participants learned the motor skill over successive runs. The groups did not differ in behavioral performance but did differ in their rCBF activity patterns. Healthy volunteers displayed blood flow increases in primary motor cortex and supplementary motor area with motor learning. The patients with schizophrenia displayed an increase in the primary visual cortex with motor learning. Changes in these regions were positively correlated with changes in each group's motor accuracy, respectively. This is the first study to employ a unique arm-reaching motor learning test to assess neural plasticity during multiple phases of motor learning in patients with schizophrenia. The patients may have an inability to rapidly tune motor cortical neural populations to a preferred direction. The visual system, however, appears to be highly compensated in schizophrenia and the inability to rapidly modulate the motor cortex may be substantially corrected by the schizophrenic group's visuomotor adaptations.

show abstract

Motor-induced brain activation in cortical, subcortical and cerebellar regions in schizophrenic inpatients. A whole brain fMRI fingertapping study

Cited by 44 publications

References 20 publications

Regional Differences in the Action of Antipsychotic Drugs: Implications for Cognitive Effects in Schizophrenic Patients

Regional Differences in the Action of Antipsychotic Drugs: Implications for Cognitive Effects in Schizophrenic Patients

Motor function deficits in schizophrenia: an fMRI and VBM study

Sequential neural changes during motor learning in schizophrenia

Contact Info

Product

Resources

About