Motor, mental and behavioral developments in infancy are associated with fatty acid pattern in breast milk and plasma of premature infants

Sabel, Karl‐Göran; Strandvik, Birgitta; Petzold, Max; Lundqvist-Persson, Cristina

doi:10.1016/j.plefa.2012.02.008

Cited by 33 publications

(31 citation statements)

References 46 publications

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“…The results of the present study are in agreement with the few previous observational studies that investigated LCPUFA Articles levels in colostrum, transitional or mature breast milk, in relation with later child cognition, and that found no strong evidence for a beneficial role of LCPUFA, in order to explain the relationship between breastfeeding and cognition (12)(13)(14)(15)(16). Most of the literature on this topic comes from randomized controlled trials.…”

Section: Discussionsupporting

confidence: 92%

“…We found negative associations between the levels of the n-6 precursor LA and two measures of development, Motor-2 and ASQ-3, together with a nonsignificant negative relationship with the CDI-2. Such association was previously highlighted among 51 preterm infants of 6 mo of age (14). In other studies, authors reported negative associations between cognition and PUFA ratios, especially LA/ALA, AA/ DHA, and total n-6/n-3 (12,14,15).…”

Section: Discussionsupporting

confidence: 53%

“…Such association was previously highlighted among 51 preterm infants of 6 mo of age (14). In other studies, authors reported negative associations between cognition and PUFA ratios, especially LA/ALA, AA/ DHA, and total n-6/n-3 (12,14,15). In our study, we observed a negative and significant association between total n-6/n-3 PUFA ratio and the ASQ-3 score, but this was not observed with Motor-2 and CDI-2.…”

Section: Discussionsupporting

confidence: 52%

“…The follow-up of the participants to 4 y of age, did not confirm this finding: the colostrum content in n-3 PUFA was not associated with cognitive development, as measured with the McCarthy Scales of Children's Abilities (13). At the same time, a smaller study of 51 preterm infants of 6 mo of age reported a negative association between the levels of the n-6 precursor LA in transitional breast milk and both mental and emotional scales of the Bayley's Scales of Infant Development (14). Using data from our large mother-child cohort study, we aimed to explore the associations of PUFA and LCPUFA levels in colostrum with cognition in early childhood.…”

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confidence: 90%

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The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort

et al. 2015

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Background: Breastfeeding has been associated with improved cognitive development. This may be explained by polyunsaturated fatty acid (PUFA) content of breast milk, especially long-chain (LC) PUFA that are needed for postnatal brain growth. Methods: Using data from the French EDEN cohort, we aimed to study whether the PUFA content of colostrum may explain observed associations between breastfeeding duration and cognitive scores at 2 and 3 y. A total of 709 breastfed children with available data on PUFA composition of milk were assessed using parent-reported questionnaires for motor and language at 2 y of age, or global cognition at 3 y. Multiple linear regressions were used to examine associations between PUFA levels and child cognitive scores, after controlling for many confounders. results: We found no association between LCPUFA levels in colostrum and child development. However, levels of linoleic acid (LA) were negatively associated with motor and cognitive scores, independently of breastfeeding duration. Children breastfed with the highest levels of LA tended to score closer to the never breastfed children than children breastfed with the lowest levels of LA. conclusion: Our findings suggest that too high levels of LA in colostrum are associated with poorer child development at 2 and 3 y.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 53%

Section: Discussionsupporting

confidence: 52%

mentioning

confidence: 90%

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The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort

et al. 2015

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“…Scientists increasingly have come to understand the importance of the ratio of n-6 to n-3 fatty acids (FAs) 6 to cognitive function (1)(2)(3)(4)(5)(6). In particular, cognitive functions subserved by the hippocampus and frontal cortex, such as memory and executive functions, are sensitive to imbalances in the n-6:n-3 ratio because of the presence of high n-6 and n-3 FAs (7), as well as the role of n-6 and n-3 in neurotransmitter concentrations (8,9), receptor density and function (10,11), and neuronal growth (12,13) in those brain areas.…”

Section: Introductionmentioning

confidence: 99%

Executive functions and the ω-6-to-ω-3 fatty acid ratio: a cross-sectional study

Sheppard

Cheatham

2017

The American Journal of Clinical Nutrition

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Background: The v-6 (n-6) to v-3 (n-3) fatty acid (FA) ratio (n-6:n-3 ratio) was previously shown to be a predictor of executive function performance in children aged 7-9 y. Objective: We aimed to replicate and extend previous findings by exploring the role of the n-6:n-3 ratio in executive function performance. We hypothesized that there would be an interaction between n-3 and the n-6:n-3 ratio, with children with low n-3 performing best with a low ratio, and those with high n-3 performing best with a high ratio. Design: Children were recruited on the basis of their consumption of n-6 and n-3 FAs. The executive function performance of 78 children aged 7-12 y was tested with the use of the Cambridge Neuropsychological Test Automated Battery and a planning task. Participants provided blood for plasma FA quantification, and the caregiver completed demographic and activity questionnaires. We investigated the role of the n-6:n-3 ratio in the entire sample and separately in children aged 7-9 y (n = 41) and 10-12 y (n = 37).

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Infant Formulae

MALTERRE,

ALONSO‐MIRAVALLES,

O'MAHONY

2024

Milk and Dairy Products

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Motor, mental and behavioral developments in infancy are associated with fatty acid pattern in breast milk and plasma of premature infants

Cited by 33 publications

References 46 publications

The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort

The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort

Executive functions and the ω-6-to-ω-3 fatty acid ratio: a cross-sectional study

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