Motor Neglect and Future Directions for Research

Sampanis, Dimitrios S.; Riddoch, Jane

doi:10.3389/fnhum.2013.00110

Cited by 14 publications

(12 citation statements)

References 20 publications

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“…19,21 Another symptom affecting output stages of stimulus processing is motor neglect, whereby a dramatic reduction in the spontaneous use of contralesional limbs is not explained by motor impairment. 27 Finally, not only the type of task 18 but also task demands [28][29][30][31] have been found to affect neglect severity.…”

Section: Usn Is a Complex Syndromementioning

confidence: 99%

<p>Unilateral Spatial Neglect After Stroke: Current Insights</p>

Gammeri¹,

Iacono²,

Ricci

et al. 2020

NDT

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Introduction: Unilateral spatial neglect (USN) is a disorder of contralesional space awareness which often follows unilateral brain lesion. Since USN impairs awareness of contralesional space/body and often of concomitant motor disorders, its presence represents a negative prognostic factor of functional recovery. Thus, the disorder needs to be carefully diagnosed and treated. Here, we attempted to present a clear and concise picture of current insights in the comprehension and rehabilitation of USN. Methods: We first provided an updated overview of USN clinical and neuroanatomical features and then highlighted recent progresses in the diagnosis and rehabilitation of the disease. In relation to USN rehabilitation, we conducted a MEDLINE literature research on three of the most promising interventions for USN rehabilitation: prismatic adaptation (PA), non-invasive brain stimulation (NIBS), and virtual reality (VR). The identified studies were classified according to the strength of their methods. Results: The last years have witnessed a relative decrement of interest in the study of neuropsychological disorders of spatial awareness in USN, but a relative increase in the study of potential interventions for its rehabilitation. Although optimal protocols still need to be defined, high-quality studies have demonstrated the efficacy of PA, TMS and tDCS interventions for the treatment of USN. In addition, preliminary investigations are suggesting the potentials of GVS and VR approaches for USN rehabilitation. Conclusion: Advancing neuropsychological and neuroscience tools to investigate USN pathophysiology is a necessary step to identify effective rehabilitation treatments and to foster our understanding of neurofunctional bases of spatial cognition in the healthy brain.

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Section: Usn Is a Complex Syndromementioning

confidence: 99%

<p>Unilateral Spatial Neglect After Stroke: Current Insights</p>

Gammeri¹,

Iacono²,

Ricci

et al. 2020

NDT

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“…20 Conversely, limiting movements of the normal hand may also be beneficial, especially in cases of left motor neglect. 21,22 All of these maneuvers have been tried in the therapeutic setting, but their effect is limited to the time the intervention is applied and do not extend long term (see the Treatment and Clinical Management section).…”

Section: Spatial Biasmentioning

confidence: 99%

Hemispatial Neglect: Clinic, Pathogenesis, and Treatment

Corbetta

2014

Semin Neurol

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Hemispatial neglect is characterized by a failure of awareness on the side of space and body opposite the site of injury, has been extensively studied for its theoretical interest in revealing brain mechanisms of awareness and attention. More recently, it has become apparent that hemispatial neglect reflects not only damage of specific anatomical regions, but also the large-scale dysfunction of networks of brain regions specialized in attention, motor, and multimodal sensory processing. Finally, although previous studies showed that the symptoms of hemispatial neglect could be effectively, albeit transiently, improved by a variety of behavioral, pharmacological, and physical interventions, only recently have treatment studies begun to show long-lasting therapeutic effects. Future advances will require the integration of advanced brain imaging methods to identify abnormal brain circuitries and-in combination with sensory, cognitive, and neural stimulation-methods to modulate activity in those circuitries.

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“…Motor neglect is twice more likely to affect patients suffering from right compared to left hemispheric stroke [39] and may have a significant impact on patient's performance and recovery. Spontaneous improvement of neglect occurs in proportion of patients, mostly in first 12-14 weeks post-stroke [39][40][41] .…”

Section: Disorders Of Intention: Motor Neglect and Motor Impersistencementioning

confidence: 99%

“…The key characteristic of motor neglect is that motor deficit may be at least partially overcome by visual, sensory or auditory stimulation by the examiner or when the patient directs his attention and volition toward the affected limb [41,42]. These observations suggest that in motor neglect, habitual movements (movements performed in automatic fashion) might be more affected than goal directed movements.…”

Section: Disorders Of Intention: Motor Neglect and Motor Impersistencementioning

confidence: 99%

Bringing order to higher order motor disorders

Kojović

Bhatia

2018

J Neurol

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Majority of movements in everyday situations are complex and involve volition, planning of the movement and selection of the motor programme, all occurring before movement execution. Higher order motor disorders may be defined as abnormal motor behaviours resulting from disruption of any of the cortical processes that precede execution of the motor act. They are common in patients with neurodegenerative disorders, psychiatric diseases and structural brain lesions. These abnormal behaviours may be overlooked in the clinic, unless specifically evoked by the examiner. We discuss clinical and pathophysiological aspects of higher order motor disorders including: (1) disorders of disinhibition, such as grasp reflex and grasping behaviour, utilisation and imitation behaviour, motor preservations and paratonia; (2) disorders of motor intention such as motor neglect and motor impersistence; (3) alien limb syndrome; and (4) motor overflow phenomena, such as mirror movements and synkinesias. A video illustration of each phenomenon is provided. We place the findings from recent neurophysiological studies within the framework of theories of motor control to provide better insight into pathophysiology of different disorders.

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Motor Neglect and Future Directions for Research

Cited by 14 publications

References 20 publications

<p>Unilateral Spatial Neglect After Stroke: Current Insights</p>

<p>Unilateral Spatial Neglect After Stroke: Current Insights</p>

Hemispatial Neglect: Clinic, Pathogenesis, and Treatment

Bringing order to higher order motor disorders

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