Motor Neuron-Skeletal Muscle Co Culture Model: A Potential Novel in Vitro and Computaional Platform to Investigate Cancer Cachexia

Neuromuscular junctions are stable in patients with cancer cachexia

“…The role of the nerve-muscle interface in human cachexia is therefore of interest to both clinician and basic scientists and relevant to our understanding of disease pathophysiology and the development of effective treatments. Thus, cancer cachexia has been the subject of coculture/informatics projects (20) and ongoing patient studies. Experimental evidence supporting a direct role for NMJs in human cachexia is, however, highly reliant on studies of animal models of related conditions (21)(22)(23).…”