Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitment

Ravanelli, Andrew M.; Appel, Bruce

doi:10.1101/gad.271312.115

Cited by 87 publications

(110 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with this, apical Par proteins localized to and promoted formation of cilia in cultured cells (Fan et al, 2004;Sfakianos et al, 2007) and reduction of Pard3 function reduced the length of photoreceptor cell cilia in zebrafish embryos (Krock and Perkins, 2014). In zebrafish embryos, Prkci and Pard3 localize to the apical membranes of dividing spinal cord progenitors but become depleted as the progenitors differentiate (Hudish et al, 2013;Ravanelli and Appel, 2015). These observations raise the possibility that modulation of the abundance and localization of apical Par protein can tune the Hh signaling response by modulating ciliogenesis or other apical membrane characteristics.…”

Section: Discussionsupporting

confidence: 53%

miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling

et al. 2016

Self Cite

View full text Add to dashboard Cite

The transition of dividing neuroepithelial progenitors to differentiated neurons and glia is essential for the formation of a functional nervous system. Sonic hedgehog (Shh) is a mitogen for spinal cord progenitors, but how cells become insensitive to the proliferative effects of Shh is not well understood. Because Shh reception occurs at primary cilia, which are positioned within the apical membrane of neuroepithelial progenitors, we hypothesized that loss of apical characteristics reduces the Shh signaling response, causing cell cycle exit and differentiation. We tested this hypothesis using genetic and pharmacological manipulation, gene expression analysis and time-lapse imaging of zebrafish embryos. Blocking the function of miR-219, a microRNA that downregulates apical Par polarity proteins and promotes progenitor differentiation, elevated Shh signaling. Inhibition of Shh signaling reversed the effects of miR-219 depletion and forced expression of Shh phenocopied miR-219 deficiency. Time-lapse imaging revealed that knockdown of miR-219 function accelerates the growth of primary cilia, revealing a possible mechanistic link between miR-219-mediated regulation of apical Par proteins and Shh signaling. Thus, miR-219 appears to decrease progenitor cell sensitivity to Shh signaling, thereby driving these cells towards differentiation.

show abstract

Section: Discussionsupporting

confidence: 53%

miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…This idea helps explain why lineage relationships appear to play less of a role in simpler nervous systems such as in C. elegans . Consistent with the idea that anatomical proximity of functionally related cell types is important for building complex nervous systems, in mammals, astrocytes and oligodendrocytes are born from the same progenitor domains as motor neurons and interneurons (Ravanelli and Appel, 2015; Rowitch and Kriegstein, 2010). Although it is currently unclear whether these cell types are derived from the same lineages in vertebrates, our results provide a striking precedent and compelling reasons that this may be the case.…”

Section: Discussionmentioning

confidence: 65%

Differing Strategies Despite Shared Lineages of Motor Neurons and Glia to Achieve Robust Development of an Adult Neuropil in Drosophila

Enriquez

Rio

Blazeski

et al. 2018

Neuron

View full text Add to dashboard Cite

SUMMARY In vertebrates and invertebrates, neurons and glia are generated in a stereotyped manner from neural stem cells, but the purpose of invariant lineages is not understood. We show that two stem cells that produce leg motor neurons in Drosophila also generate neuropil glia, which wrap and send processes into the neuropil where motor neuron dendrites arborize. The development of the neuropil glia and leg motor neurons is highly coordinated. However, although motor neurons have a stereotyped birth order and transcription factor code, the number and individual morphologies of the glia born from these lineages are highly plastic, yet the final structure they contribute to is highly stereotyped. We suggest that the shared lineages of these two cell types facilitate the assembly of complex neural circuits and that the two birth order strategies—hardwired for motor neurons and flexible for glia—are important for robust nervous system development, homeostasis, and evolution.

show abstract

“… Schematic representation of how different waves of OPC generation populate different regions of the CNS throughout development (panels: left/orange: forebrain; middle/green: cerebellum; right/purple: spinal cord). OPCs originating from different niches are represented by differently colored dots (blue, red, and green) (based on data by Fogarty, Richardson, & Kessaris, ; Grimaldi, Parras, Guillemot, Rossi, & Wassef, ; Hashimoto et al, ; Kessaris et al, ; Ravanelli & Appel, ; Vallstedt, Klos, & Ericson, )…”

Section: Opc Generationmentioning

confidence: 99%

Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury

Tilborg

Theije

Hal

et al. 2017

Glia

207

184

View full text Add to dashboard Cite

Infants born prematurely are at high risk to develop white matter injury (WMI), due to exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the maturation of oligodendrocytes (OLs), thereby causing deficits in myelination. To elucidate the precise pathophysiology underlying perinatal WMI, it is essential to fully understand the cellular mechanisms contributing to healthy/normal white matter development. OLs are responsible for myelination of axons. During brain development, OLs are generally derived from neuroepithelial zones, where neural stem cells committed to the OL lineage differentiate into OL precursor cells (OPCs). OPCs, in turn, develop into premyelinating OLs and finally mature into myelinating OLs. Recent studies revealed that OPCs develop in multiple waves and form potentially heterogeneous populations. Furthermore, it has been shown that myelination is a dynamic and plastic process with an excess of OPCs being generated and then abolished if not integrated into neural circuits. Myelination patterns between rodents and humans show high spatial and temporal similarity. Therefore, experimental studies on OL biology may provide novel insights into the pathophysiology of WMI in the preterm infant and offers new perspectives on potential treatments for these patients.

show abstract

Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitment

Cited by 87 publications

References 61 publications

miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling

miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling

Differing Strategies Despite Shared Lineages of Motor Neurons and Glia to Achieve Robust Development of an Adult Neuropil in Drosophila

Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury

Contact Info

Product

Resources

About