Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience

Oxley, Thomas J.; Yoo, Peter E.; Rind, Gil S.; Ronayne, Stephen M.; Lee, C M Sarah; Bird, Christin; Hampshire, Victoria; Sharma, Rahul; Morokoff, Andrew; Williams, Daryl L.; MacIsaac, Christopher; Howard, Mark; Irving, Lou; Vrljic, Ivan; Williams, Cameron; John, Sam E.; Weissenborn, Frank; Dazenko, Madeleine; Balabanski, Anna H; Friedenberg, David A.; Burkitt, Anthony N.; Wong, Yan T.; Drummond, Katharine J.; Desmond, Patricia; Weber, Douglas J.; Denison, Timothy; Hochberg, Leigh R.; Mathers, Susan; O’Brien, Terence J.; May, Clive N.; Mocco, J; Grayden, David B.; Campbell, Bruce; Mitchell, Peter; Opie, Nicholas L.

doi:10.1136/neurintsurg-2020-016862

Cited by 147 publications

(111 citation statements)

References 22 publications

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“…Tables 2 , 3 list a diverse range of BCI applications exploiting EEG. Both invasive and non-invasive signal acquisitions have recently shown that reliable long-term (i.e., for at least several months) use of BCI systems is quite feasible (Saeedi et al, 2016 ; Sauter-Starce et al, 2019 ; Shahriari et al, 2019 ; Oxley et al, 2020 ).…”

Section: Challengesmentioning

confidence: 99%

“…Capturing high-fidelity cortical signals, this technology will significantly reduce the risk factors of craniotomy. A follow-up study has recently demonstrated successful implantation of the strentrode in humans for long-term neural signal recording (Oxley et al, 2020 ). The information transfer rate for strentrode-based BCI was comparable to the landmark study by Vansteensel et al with implanted electrodes (Vansteensel et al, 2016 ).…”

Section: Neuroplasticity Sensors Signal Processing Modeling Anmentioning

confidence: 99%

“…Creating broad awareness of BCI technology and its pros and cons would educate people, who fear unnecessary technological dependency (Hobson et al, 2017 ). However, successful clinical trials of sophisticated devices such as strentrode or WIMAGINE are essential to demonstrate potential advantages, especially for people suffering from any form of cognitive disability (Sauter-Starce et al, 2019 ; Oxley et al, 2020 ). In the case of healthy users, it should not be too difficult to create acceptance to a broader community when dry electrodes could offer the long-term operation of a BCI application with little maintenance effort (Di Flumeri et al, 2019 ; Marini et al, 2019 ; Hinrichs et al, 2020 ).…”

Section: Ethical Concerns and Socioeconomic Contextsmentioning

confidence: 99%

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Progress in Brain Computer Interface: Challenges and Opportunities

Saha

Mamun

Ahmed

et al. 2021

Front. Syst. Neurosci.

227

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Brain computer interfaces (BCI) provide a direct communication link between the brain and a computer or other external devices. They offer an extended degree of freedom either by strengthening or by substituting human peripheral working capacity and have potential applications in various fields such as rehabilitation, affective computing, robotics, gaming, and neuroscience. Significant research efforts on a global scale have delivered common platforms for technology standardization and help tackle highly complex and non-linear brain dynamics and related feature extraction and classification challenges. Time-variant psycho-neurophysiological fluctuations and their impact on brain signals impose another challenge for BCI researchers to transform the technology from laboratory experiments to plug-and-play daily life. This review summarizes state-of-the-art progress in the BCI field over the last decades and highlights critical challenges.

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Section: Challengesmentioning

confidence: 99%

Section: Neuroplasticity Sensors Signal Processing Modeling Anmentioning

confidence: 99%

Section: Ethical Concerns and Socioeconomic Contextsmentioning

confidence: 99%

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Progress in Brain Computer Interface: Challenges and Opportunities

Saha

Mamun

Ahmed

et al. 2021

Front. Syst. Neurosci.

227

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“…A novel approach to intracranial recording, via electrodes attached to an endovascular stent [ 55 ], is now in clinical feasibility trials. Such systems, while low bandwidth, may represent an effective solution for some individuals with severe disability [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Home Use of a Percutaneous Wireless Intracortical Brain-Computer Interface by Individuals With Tetraplegia

Simeral

Hosman²,

Saab³

et al. 2021

IEEE Trans. Biomed. Eng.

108

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Objective. Individuals with neurological disease or injury such as amyotrophic lateral sclerosis, spinal cord injury or stroke may become tetraplegic, unable to speak or even locked-in. For people with these conditions, current assistive technologies are often ineffective. Brain-computer interfaces are being developed to enhance independence and restore communication in the absence of physical movement. Over the past decade, individuals with tetraplegia have achieved rapid on-screen typing and pointand-click control of tablet apps using intracortical brain-computer interfaces (iBCIs) that decode intended arm and hand movements from neural signals recorded by implanted microelectrode arrays. However, cables used to convey neural signals from the brain tether participants to amplifiers and decoding computers and require expert oversight, severely limiting when and where iBCIs could be available for use. Here, we demonstrate the first human use of a wireless broadband iBCI. Methods. Based on a prototype system previously used in pre-clinical research, we replaced the external cables of a 192-electrode iBCI with wireless transmitters and achieved high-resolution recording and decoding of broadband field potentials and spiking activity from people with paralysis. Two participants in an ongoing pilot clinical trial

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“…[13][14][15]. Recently, several new endovascular bioelectronic devices have been developed that exemplify the benefits of stimulating neural tissue through the vasculature [16][17][18][19]. However, these devices have stimulation leads that are wired to pulse generators or centimeter-sized inductive coils.…”

mentioning

confidence: 99%

Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Chen

Kan

et al. 2021

Preprint

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Implanted bioelectronic devices have the potential to treat disorders that are resistant to traditional pharmacological therapies; however, reaching many therapeutic nerve targets requires invasive surgeries and implantation of centimeter-sized devices. Here we show that it is possible to stimulate peripheral nerves from within blood vessels using a millimeter-sized wireless implant. By directing the stimulating leads through the blood vessels we can target specific nerves that are difficult to reach with traditional surgeries. Furthermore, we demonstrate this endovascular nerve stimulation (EVNS) with a millimeter sized wireless stimulator that can be delivered minimally invasively through a percutaneous catheter which would significantly lower the barrier to entry for neuromodulatory treatment approaches because of the reduced risk. This miniaturization is achieved by using magnetoelectric materials to efficiently deliver data and power through tissue to a digitally-programmable 0.8 mm2 CMOS system-on-a-chip. As a proof-of-principle we show wireless stimulation of peripheral nerve targets both directly and from within the blood vessels in rodent and porcine models. The wireless EVNS concept described here provides a path toward minimally invasive bioelectronics where mm-sized implants combined with endovascular stimulation enable access to a number of nerve targets without open surgery or implantation of battery-powered pulse generators.

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Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience

Cited by 147 publications

References 22 publications

Progress in Brain Computer Interface: Challenges and Opportunities

Progress in Brain Computer Interface: Challenges and Opportunities

Home Use of a Percutaneous Wireless Intracortical Brain-Computer Interface by Individuals With Tetraplegia

Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

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