Motor reorganization during simulation of gravitational unloading

Fedianin, Artur; Zaytceva, Tatiana; Baltin, Maxim; Bikeeva, Sofya; Smirnova, V. V.; Sachenkov, Oskar; Baltina, Tatyana; Eremeev, Anton

doi:10.1109/cnn56452.2022.9912500

Cited by 2 publications

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“…Further processing was performed by the author's software in MATLAB. The entire methodology is described in detail in [37], and features of the analysis methodology for the case of animals with SCI are disclosed in detail in [31,38,39].…”

Section: Motor Function Analysis By Vicon Video Capture Systemmentioning

confidence: 99%

“…To estimate movement deviations, standard deviation was calculated. Additionally, the distribution of the joint angle data was presented as follows: The entire methodology is described in detail in [37], and features of the analysis methodology for the case of animals with SCI are disclosed in detail in [31,38,39].…”

Section: Motor Function Analysis By Vicon Video Capture Systemmentioning

confidence: 99%

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Functional State of the Motor Centers of the Lumbar Spine after Contusion (Th8-Th9) with Application of Methylprednisolone-Copolymer at the Site of Injury

et al. 2023

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Spinal cord injuries must be treated as soon as possible. Studies of NASCIS protocols have questioned the use of methylprednisolone therapy. This study aimed to evaluate the effect of local delivery of methylprednisolone succinate in combination with a tri-block copolymer in rats with spinal cord injury. The experiments were conducted in accordance with the bioethical guidelines. We evaluated the state of the motor centers below the level of injury by assessing the amplitude of evoked motor responses in the hind limb muscles of rats during epidural stimulation. Kinematic analysis was performed to examine the stepping cycle in each rat. Trajectories of foot movements were plotted to determine the range of limb motion, maximum foot lift height, and lateral deviation of the foot in rats on the 21st day after spinal cord injury. We have shown that the local application of methylprednisolone succinate in combination with block copolymer leads to recovery of center excitability by 21 days after injury. In rats, they recovered weight-supported locomotion, directional control of walking, and balance. The proposed assessment method provides valuable information on gait disturbances following injury and can be utilized to evaluate the quality of therapeutic interventions.

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