Motor representation of rhythmic jaw movements in the amygdala of guinea pigs

Ueno, Yoshio; Higashiyama, Makoto; Haque, Tahsinul; Masuda, Yuji; Katagiri, Ayano; Toyoda, Hiroki; Uzawa, Narikazu; Yoshida, Atsushi; Kato, Takafumi

doi:10.1016/j.archoralbio.2022.105362

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…The subsequent dopamine depletion in the caudate nucleus and N.Acc is associated with decreased dopamine functioning in the mesolimbic pathway, where dopamine normally acts as an inhibitor to spontaneous movement ( 38 ). This observation has been supported by the recent findings of Ueno et al ( 39 ), where the motor representation of rhythmic jaw movement of the amygdala was assessed in an animal model. The authors concluded that the ventral part of the amygdala (medial, basal and cortical) is highly involved in the induction of rhythmic jaw movement and that the role of limbic system in the genesis of bruxism warrants further investigation ( 39 ) ( Fig.…”

Section: Effect Of Stress On the Genesis Of Bruxismsupporting

confidence: 74%

“…This observation has been supported by the recent findings of Ueno et al ( 39 ), where the motor representation of rhythmic jaw movement of the amygdala was assessed in an animal model. The authors concluded that the ventral part of the amygdala (medial, basal and cortical) is highly involved in the induction of rhythmic jaw movement and that the role of limbic system in the genesis of bruxism warrants further investigation ( 39 ) ( Fig. 2 ).…”

Section: Effect Of Stress On the Genesis Of Bruxismsupporting

confidence: 74%

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Neurobiology of bruxism: The impact of stress (Review)

Pavlou,

Spandidos,

Zoumpourlis

et al. 2024

Biomed Rep

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Bruxism is a non-functional involuntary muscle activity that affects more than one-third of the population at some point in their lives. A number of factors have been found to be related to the etiopathogenesis of bruxism; therefore, the condition is considered multifactorial. The most commonly accepted factor is stress. Stress has long been considered to increase muscle tone and to reduce the pain threshold. Current evidence indicates that exposure to chronic stress, distress and allostatic load ignite neurological degeneration and the attenuation of critical neuronal pathways that are highly implicated in the orofacial involuntary muscle activity. The present review discusses the negative effects that chronic stress exerts on certain parts of the central nervous system and the mechanisms through which these changes are involved in the etiopathogenesis of bruxism. The extent of these morphological and functional changes on nerves and neuronal tracts provides valuable insight into the obstacles that need to be overcome in order to achieve successful treatment. Additionally, particular emphasis is given on the effects of bruxism on the central nervous system, particularly the activation of the hypothalamic-pituitary-adrenal axis, as this subsequently induces an increase in circulating corticosterone levels, also evidenced by increased levels of salivary cortisol, thereby transforming bruxism into a self-reinforcing loop.

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Section: Effect Of Stress On the Genesis Of Bruxismsupporting

confidence: 74%

Section: Effect Of Stress On the Genesis Of Bruxismsupporting

confidence: 74%

Neurobiology of bruxism: The impact of stress (Review)

Pavlou,

Spandidos,

Zoumpourlis

et al. 2024

Biomed Rep

View full text Add to dashboard Cite

show abstract

“…This was evidenced by increased levels of acetylcholinesterase (Ache) and creatine kinase (CK-MM) in the masseter muscles (61). In another study by Ueno et al (62), it was demonstrated that activation of the ventral part of amygdala in guinea pigs may cause rhythmic jaw movement.…”

Section: Nutrient Insufficiencies and Deficiencies Involved In The Pa...mentioning

confidence: 98%

Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review)

Pavlou,

Spandidos,

Zoumpourlis

et al. 2023

Exp Ther Med

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Stress has been well-documented to have a significant role in the etiopathogenesis of bruxism. Activation of the hypothalamic-pituitary-adrenal axis (HPA) and subsequent release of corticosteroids lead to increased muscle activity. Neurological studies have demonstrated that chronic stress exposure induces neurodegeneration of important neuronal structures and destabilization of the mesocortical dopaminergic pathway. These disruptions impair the abilities to counteract the overactivity of the HPA axis and disinhibit involuntary muscle activity, while at the same time, there is activation of the amygdala. Recent evidence shows that overactivation of the amygdala under stressful stimuli causes rhythmic jaw muscle activity by over activating the mesencephalic and motor trigeminal nuclei. The present review aimed to discuss the negative effects of certain vitamin and mineral deficiencies, such as vitamin D, magnesium, and omega-3 fatty acids, on the central nervous system. It provides evidence on how such insufficiencies may increase stress sensitivity and neuromuscular excitability and thereby reduce the ability to effectively respond to the overactivation of the sympathetic nervous system, and also how stress can in turn lead to these insufficiencies. Finally, the positive effects of individualized supplementation are discussed in the context of diminishing anxiety and oxidative stress, neuroprotection and in the reversal of neurodegeneration, and also in alleviating/reducing neuromuscular symptoms.

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