Motor Unit Number Estimation in Spastic Biceps Brachii Muscles of Chronic Stroke Survivors Before and After BoNT Injection

Liu, Yang; Chen, Yen‐Ting; Zhang, Chuan; Zhou, Ping; Li, Sheng; Zhang, Yingchun

doi:10.1109/tbme.2022.3208078

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…The findings of the current CMAP scan study add new evidence of motor unit changes due to stroke, manifested as significantly smaller CMAP amplitude and STEPIX in the paretic muscle compared with the contralateral muscle. This is in line with previous MUNE studies that reported varying degrees of CMAP and motor unit number reduction after stroke ( Arasaki et al, 2006 ; Choi et al, 2007 ; Hara et al, 2000 ; Hara et al, 2004 ; Kouzi et al, 2014 ; Li et al, 2016a ; Liu et al, 2023 ; McComas et al, 1973 ). The minimum current intensity (S0) for evoking a motor unit was significantly higher for the paretic muscle compared with the contralateral side, suggesting altered axon excitability properties after stroke ( Klein et al, 2020 ; Turan and Zİnnuroğlu, 2020 ).…”

Section: Discussionsupporting

confidence: 93%

“…A collective of findings has been reported revealing complex structural and control property changes after stroke. In addition to different types of voluntary EMG analysis, motor unit number estimation (MUNE) has been applied to examine paretic muscles in stroke survivors by stimulating motor nerves and recording compound muscle action potentials (CMAPs) ( Arasaki et al, 2006 ; Choi et al, 2007 ; Hara et al, 2000 ; Hara et al, 2004 ; Kouzi et al, 2014 ; Liu et al, 2023 ; McComas et al, 1973 ). While varying degrees of motor unit loss have been reported in stroke by different MUNE methods (such as multipoint stimulation MUNE ( Arasaki et al, 2006 ) and F wave MUNE ( Li et al, 2016a )), the methodology limitations of the MUNE should be acknowledged.…”

Section: Introductionmentioning

confidence: 99%

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Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke

Chen¹,

Lu²,

et al. 2023

Sci. China Life Sci.

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This study presents a novel compound muscle action potential (CMAP) examination of motor unit changes in paretic muscle post stroke. CMAP scan of the first dorsal interosseous (FDI) muscle was performed bilaterally in 16 chronic stroke subjects. Various parameters were derived from the CMAP scan to examine paretic muscle changes, including CMAP amplitude, D50, step index (STEPIX) and amplitude index (AMPIX). A significant decrease in CMAP amplitude and STEPIX was observed in paretic muscles compared with contralateral muscles (CMAP amplitude: paretic (9.0±0.5) mV, contralateral (11.3±0.9) mV, P=0.024; STEPIX: paretic 101.2±7.6, contralateral 121.9±6.5, P=0.020). No significant difference in D50 and AMPIX was observed between the paretic and contralateral sides (P>0.05). The findings revealed complex paretic muscle changes including motor unit degeneration, muscle fiber denervation, reinnervation and atrophy, providing useful insights to help understand neuromuscular mechanisms associated with weakness and other functional deterioration post stroke. The CMAP scan experimental protocols and the applied processing methods are noninvasive, convenient, and automated, offering practical benefits for clinical application.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke

Chen¹,

Lu²,

et al. 2023

Sci. China Life Sci.

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The Effectiveness of High Intensity Electromagnetic Stimulation in Spastic Stroke Patients

Khan

Ali

Khan

et al. 2023

PBMJ

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In stroke patients, spasticity level allows to predict the patient’s rehabilitation outcome. Objective: To evaluate the anti-spastic effectiveness of high intensity electromagnetic stimulation (HIES) in stroke patients. Methods: Twenty (n=20) spastic stroke patients were assigned randomly into two groups; the study participants were briefed about the aim & methodology of the study & written consent were taken. Ten therapy sessions were given to the stroke’s patient spastic muscles in the treatment group (TG) with HIES, while in the controlled group (CG) 10 electrotherapy session along with kinesiotherapy was delivered. The outcome measures of the study were MAS (Modified Ashworth scale) & Barthel index (BI) was used as, for spasticity and for the patient’s quality life evaluation, respectively. After the one-month therapeutic plan results were obtained & compared based on the pre-treatment score & post-treatment score on the afore-mentioned specified outcome measures. Results: The analysis of data shows that treatment group score improved significantly, up to 68% & similarly, spasticity decreased from 2.86±0.075 in the beginning to 0.58±0.86 points on MAS, while on the other hand, control group score up to 31% enhanced & on the MAS scale, spasticity diminished from 2.45±0.57 in the start to 1.49±0.87 points. As per Barthel index, improvement for CG & TG was 72% & 80% respectively. Conclusions: This study results shows that high intensity electromagnetic stimulation (EMS) is highly effective in the reduction of stroke-specific spasticity.

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Motor Unit Number Estimation in Spastic Biceps Brachii Muscles of Chronic Stroke Survivors Before and After BoNT Injection

Cited by 2 publications

References 43 publications

Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke

Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke

The Effectiveness of High Intensity Electromagnetic Stimulation in Spastic Stroke Patients

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