Motor Unit Number Index of the Upper Trapezius: A Meta-Analysis and Cross-sectional Study of Its Reliability

Abrahão, Agessandro; Phung, Liane; Fam, David; Escorcio‐Bezerra, Marcio Luiz; Robinson, Lawrence R.; Jones, Kelvin E.; Zinman, Lorne

doi:10.1017/cjn.2023.20

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…The following five muscles were tested: 1. abductor pollicis brevis (APB); 2. abductor digiti minimi of the hand (ADM); 3. first dorsal interosseus of the hand (FDI); 4. tibialis anterior (TA) and 5. trapezius (Trap). The electrode placement for individual muscles was standardized according to guidelines [23,42].…”

Section: Munix Proceduresmentioning

confidence: 99%

“…Nevertheless, they show good inter-rater and test-retest reliability. MUNIX has been applied to small, distal limb muscles, including the abductor pollicis brevis (APB), abductor digiti minimi (ADM), extensor digitorum brevis (EDB) and abductor hallucis (HA), as well as to larger muscles such as the biceps brachii (BB), tibialis anterior (TA) and trapezius [21][22][23][24]. The motor unit size index (MUSIX) is another electrophysiological parameter, derived from MUNIX.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Usefulness of Motor Unit Number Index (MUNIX) in Patients Newly Diagnosed with Amyotrophic Lateral Sclerosis

Risi,

Cotti Piccinelli,

Gazzina

et al. 2023

JCM

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The MUNIX technique allows us to estimate the number and size of surviving motor units (MUs). Previous studies on ALS found correlations between MUNIX and several clinical measures, but its potential role as a predictor of disease progression rate (DPR) has not been thoroughly evaluated to date. We aimed to investigate MUNIX’s ability to predict DPR at a six-month follow up. Methods: 24 ALS patients with short disease duration (<24 months from symptoms’ onset) were enrolled and divided according to their baseline DPR into two groups (normal [DPR-N] and fast [DPR-F] progressors). MUNIX values were obtained from five muscles (TA, APB, ADM, FDI, Trapezius) and averaged for each subject. Results: MUNIX was found to predict DPR at follow up in a multivariable linear regression model; namely, patients with lower MUNIX values were at risk of showing greater DPR scores at follow up. The result was replicated in a simple logistic regression analysis, with the dichotomic category “MUNIX-Low” as the independent variable and the outcome “DPR-F” as the dependent variable. Conclusions: our results pave the way for the use of the MUNIX method as a prognostic tool in early ALS, enabling patients’ stratification according to their rates of future decline.

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Section: Munix Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prognostic Usefulness of Motor Unit Number Index (MUNIX) in Patients Newly Diagnosed with Amyotrophic Lateral Sclerosis

Risi,

Cotti Piccinelli,

Gazzina

et al. 2023

JCM

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Reliability of MScanFit Motor Unit Number Estimation in the Trapezius Muscle

Sørensen,

Tankisi

2024

Muscle and Nerve

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Introduction/AimsMScanFit motor unit number estimation (MUNE) is the most recent MUNE method which has shown promising results in extremity muscles, but it has not been applied to bulbar muscles. Bulbar muscles are particularly important in the diagnosis of amyotrophic lateral sclerosis (ALS). This study aimed to investigate the feasibility and reliability of MScanFit MUNE in the accessory nerve and trapezius muscles.MethodsA total of twenty healthy participants were examined twice within 1–2 weeks. We extracted the MScanFit MUNE and size parameter, and compound muscle action potential (CMAP) amplitude values. The reliability of these parameters was assessed using the intra‐rater coefficient of variation (CoV), intraclass correlation coefficient (ICC), and Bland–Altman plots. We also correlated MUNE values with CMAP amplitudes using correlation coefficients.ResultsMean MUNE values (Day 1 = 132.1 and Day 2 = 137.4), CMAP amplitudes (Day 1 = 9.71 mV and Day 2 = 10.10 mV) and size parameters did not differ between the two sessions (p > 0.05). CoV showed excellent reliability for MUNE values, size parameters, and CMAP amplitudes (CoV < 7%) whereas ICCs showed moderate reliability for MUNE values (ICC = 0.619), poor to moderate reliability for size parameters (between 0.393 and 0.689), and good reliability for CMAP amplitude (ICC = 0.864) There was no correlation between MUNE values and CMAP amplitudes.DiscussionMScanFit MUNE is applicable and mostly reliable in the trapezius muscle. Further studies in patients are needed to investigate the sensitivity of MScanFit in this muscle in detecting motor unit loss, particularly in ALS.

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Motor Unit Number Index of the Upper Trapezius: A Meta-Analysis and Cross-sectional Study of Its Reliability

Cited by 2 publications

References 10 publications

Prognostic Usefulness of Motor Unit Number Index (MUNIX) in Patients Newly Diagnosed with Amyotrophic Lateral Sclerosis

Prognostic Usefulness of Motor Unit Number Index (MUNIX) in Patients Newly Diagnosed with Amyotrophic Lateral Sclerosis

Reliability of MScanFit Motor Unit Number Estimation in the Trapezius Muscle

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