Mountain Ultra-Marathon (UTMB) Impact on Usual and Emerging Cardiac Biomarkers

Goff, Caroline Le; Gergelé, Laurent; Seidel, Laurence; Cavalier, Étienne; Kaux, Jean‐François

doi:10.3389/fcvm.2022.856223

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…[13] The mechanisms underlying these findings may relate to myocardial processes, ranging from benign leakage from the cardiac myocyte membrane to myocyte necrosis. [14][15][16] However, the significance of the elevated levels of these biomarkers in athletes remains uncertain. [13,17] We hypothesized that competing in the 246-km MUM may affect autonomic nervous system activity and trigger exerciseinduced arrhythmias in runners.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac autonomic regulation following a 246-km mountain ultra-marathon: An observational study

Tsai,

Kao,

How

et al. 2024

Medicine

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Physical exercise requires integrated autonomic and cardiovascular adjustments to maintain homeostasis. We aimed to observe acute posture-related changes in blood pressure, and apply a portable noninvasive monitor to measure the heart index for detecting arrhythmia among elite participants of a 246-km mountain ultra-marathon. Nine experienced ultra-marathoners (8 males and 1 female) participating in the Run Across Taiwan Ultra-marathon in 2018 were enrolled. The runners’ Heart Spectrum Blood Pressure Monitor measurements were obtained in the standing and supine positions before and immediately after the race. Their high-sensitivity troponin T and N-terminal proB-type natriuretic peptide levels were analyzed 1 week before and immediately after the event. Heart rate was differed significantly in the immediate postrace assessment compared to the prerace assessment, in both the standing (P = .011; d = 1.19) and supine positions (P = .008; d = 1.35). Postural hypotension occurred in 4 (44.4%) individuals immediately postrace. In 3 out of 9 (33.3%) recruited finishers, the occurrence of premature ventricular complex signals in the standing position was detected; premature ventricular complex signal effect was observed in the supine position postrace in only 1 participant (11.1%). Premature ventricular complex signal was positively correlated with running speed (P = .037). Of the 6 individuals who completed the biochemical tests postrace, 2 (33.3%) had high-sensitivity troponin T and 6 (100%) had N-terminal proB-type natriuretic peptide values above the reference interval. A statistically significant increase was observed in both the high-sensitivity troponin T (P = .028; d = 1.97), and N-terminal proB-type natriuretic peptide (P = .028; d = 2.91) levels postrace compared to prerace. In conclusion, significant alterations in blood pressure and heart rate were observed in the standing position, and postexercise (postural) hypotension occurred among ultra-marathoners. The incidence of premature ventricular complexes was higher after the race than before.

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Section: Introductionmentioning

confidence: 99%

“…[13] The mechanisms underlying these findings may relate to myocardial processes, ranging from benign leakage from the cardiac myocyte membrane to myocyte necrosis. [14–16] However, the significance of the elevated levels of these biomarkers in athletes remains uncertain. [13,17]…”

Section: Introductionmentioning

confidence: 99%

Cardiac autonomic regulation following a 246-km mountain ultra-marathon: An observational study

Tsai,

Kao,

How

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

“…Recently, it has been observed that a troponin exerciseinduced increase above the 99th percentile could be an early marker of mortality and cardiovascular events (27) notably in participants with hypertension (28). Nevertheless, these results remain to be discussed (7,26,29,30). To date, no study has reported a relationship between echocardiographic characteristics and cardiac biomarkers in long distance runners.…”

Section: Introductionmentioning

confidence: 99%

Relationship between echocardiographic characteristics and cardiac biomarkers during long-distance trail running

Jouffroy

Hergault

Antero

et al. 2022

Front. Cardiovasc. Med.

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BackgroundEven if the beneficial cardiovascular effects of moderate exercise are recognized, effects of prolonged and intense exercise are still debated. This study aims to detect cardiovascular changes associated with long endurance running by assessing the relationship between echocardiographic parameters and cardiac biomarkers during long-distance trail running.MethodsWe performed a prospective observational study that included 20 participants who were all amateur runners (median age of 41 years old, still alive after a 7-year clinical follow-up) from 80-km trail running. All the participants underwent an echocardiographic examination and venous blood sampling before the race, at the intermediate refreshment checkpoints of the race (21st and 53rd km), and within 10 min after arrival.ResultsMitral E/A velocity ratio and mitral TDI e’ wave were significantly decreased at the 21st km to arrival (p < 0.05). Mitral S wave and global longitudinal strain (GLS) were significantly decreased from the 53rd km to arrival (p < 0.05 for 53rd and 80th km). As compared to baseline, T-troponin and NT-proBNP were significantly increased at the 21st km in all the participants, but T-troponin values were systematically increased above the significative threshold. Diastolic echocardiographic abnormalities were mainly observed among participants with highest NT-proBNP (> 77 ng.l–1) values at the 21st km. As compared to baseline, mitral e’ wave was significantly decreased (–35%) in participants with highest values of NT-proBNP. Similarly, GLS was also depressed among participants with highest troponin values at the 53rd km (p = 0.01 for 53rd km and p = 0.04 for arrival).ConclusionDuring the long-distance trail running, the early LV decrease in diastolic echocardiographic parameters is associated with increase in NT pro-BNP blood levels, and the decrease in LV systolic echocardiographic parameters later is associated with increase in T-troponin blood levels.

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Mountain Ultra-Marathon (UTMB) Impact on Usual and Emerging Cardiac Biomarkers

Cited by 2 publications

References 23 publications

Cardiac autonomic regulation following a 246-km mountain ultra-marathon: An observational study

Cardiac autonomic regulation following a 246-km mountain ultra-marathon: An observational study

Relationship between echocardiographic characteristics and cardiac biomarkers during long-distance trail running

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