2011
DOI: 10.2174/156802611796117621
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Mouse and Human Embryonic Stem Cells: Can They Improve Human Health by Preventing Disease?

Abstract: Given the vast number of chemicals that are released into the environment each year, it is imperative that we develop new predictive models to identify toxicants before unavoidable exposure harms the health of humans and other organisms. In vitro models are especially attractive in predictive toxicology as they can greatly reduce assay costs and animal usage while identifying those chemicals that may require further in vivo evaluation. With the derivation of both mouse and human embryonic stem cells, new oppor… Show more

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Cited by 27 publications
(10 citation statements)
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“…7375 Numerous assays can be done in vitro with different cell types, using different concentrations of THS, and different experimental conditions. Assays can be acute or chronic, end points can be single or multiplexed, and designs can be low- or high-throughput.…”
Section: Progress and New Evidencementioning
confidence: 99%
“…7375 Numerous assays can be done in vitro with different cell types, using different concentrations of THS, and different experimental conditions. Assays can be acute or chronic, end points can be single or multiplexed, and designs can be low- or high-throughput.…”
Section: Progress and New Evidencementioning
confidence: 99%
“…These include studies on important cellular processes in various types of cells, including stem cells [26,27,28,29,30,31,32,33], animal-based research [34,35,36], and human health impact [23]. Majority of these studies have been discussed in the recent review by Jacob et al [7].…”
Section: Early Life Ths Exposure Affects Body Mass and The Developmentioning
confidence: 99%
“…Because stem cells are present throughout life, their risk of accumulating damage is high. Stem cells are also often more sensitive to stress than differentiated cells (Bahl et al., 2012, Behar et al., 2014), making them excellent models for evaluating safe limits of exposure to potential toxicants (Betts, 2010, Liu et al., 2017, Talbot et al., 2014, Talbot and Lin, 2011, Yin et al., 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Toxicants, such as tobacco smoke, have detrimental effects on the health of stem cells (Kee et al., 2010, Lin et al., 2010, Lin et al., 2009, Lin et al., 2015, Talbot, 2008, Talbot and Lin, 2011). Stem cells exposed to tobacco products or nicotine have diminished regenerative potential because they are less proliferative, migratory, and able to differentiate (Greenberg et al., 2017, Ng et al., 2015, Shaito et al., 2017).…”
Section: Introductionmentioning
confidence: 99%