Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus

Takahashi, Hirokazu; Umeda, Nanae; Tsutsumi, Yoko; Fukumura, Ryutaro; Ohkaze, Hajime; Sujino, Mitsugu; Horst, Gijsbertus T. J. van der; Yasui, Akira; Inouye, Shin Ichi T; Fujimori, A.; Ohhata, Tatsuya; Araki, Ryoko; Abe, Masumi

doi:10.1016/s0169-328x(02)00543-0

Cited by 69 publications

(43 citation statements)

References 32 publications

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“…The absence of Dexras1 restructures photic sensitivity as a function of the circadian phase Given that Dexras1 is rhythmically expressed in the SCN (Panda et al, 2002;Ueda et al, 2002;Takahashi et al, 2003), and that clock entrainment is driven by phase-regulated signaling pathways, Dexras1 may be uniquely positioned to differentially contribute to photic entrainment as a function of circadian time. To begin to address this issue, we constructed a photic PRC of wildtype and dexras1 Ϫ/Ϫ mice.…”

Section: Resultsmentioning

confidence: 99%

“…Potentially, rhythmic availability of a key signaling molecule within an input pathway or, alternatively, a modulator of such a pathway confers both phase specificity and sensitivity to the stimulus. One such candidate is Dexras1, a Ras-like G-protein that exhibits clock-dependent rhythms of expression in the SCN (Cismowski et al, 1999;Panda et al, 2002;Ueda et al, 2002;Takahashi et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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The Molecular Gatekeeper Dexras1 Sculpts the Photic Responsiveness of the Mammalian Circadian Clock

Cheng¹,

Dziema²,

Papp³

et al. 2006

J. Neurosci.

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The mammalian master clock, located in the suprachiasmatic nucleus (SCN), is exquisitely sensitive to photic timing cues, but the key molecular events that sculpt both the phasing and magnitude of responsiveness are not understood. Here, we show that the Ras-like G-protein Dexras1 is a critical factor in these processes. Dexras1-deficient mice (dexras1 Ϫ/Ϫ ) exhibit a restructured nighttime phase response curve and a loss of gating to photic resetting during the day. Dexras1 affects the photic sensitivity by repressing or activating time-of-day-specific signaling pathways that regulate extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK). During the late night, Dexras1 limits the capacity of pituitary adenylate cyclase (PAC) activating peptide (PACAP)/PAC1 to affect ERK/MAPK, and in the early night, light-induced phase delays, which are mediated predominantly by NMDA receptors, are reduced as reported previously. Daytime photic phase advances are mediated by a novel signaling pathway that does not affect the SCN core but rather stimulates ERK/MAPK in the SCN shell and triggers downregulation of clock protein expression.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Molecular Gatekeeper Dexras1 Sculpts the Photic Responsiveness of the Mammalian Circadian Clock

Cheng¹,

Dziema²,

Papp³

et al. 2006

J. Neurosci.

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“…Both AGS1 and Rhes have an extended carboxyl terminus as compared with Ras family proteins, and both proteins interact with G i /G o and regulate G protein signaling (Cismowski et al, , 2000Graham et al, 2002Graham et al, , 2004Takesono et al, 2002;Vargiu et al, 2004;Nguyen and Watts, 2005;Harrison and He, 2011). AGS1 has a range of functional roles, including inhibition of cell growth, N-methyl-D-aspartate receptor signaling, regulation of the circadian rhythm, and regulation of hormone secretion (Fang et al, 2000;Graham et al, 2001;Jaffrey et al, 2002;Takahashi et al, 2003;Cheng et al, 2004;Vaidyanathan et al, 2004;Lellis-Santos et al, 2012;McGrath et al, 2012;Chen et al, 2013;Harrison et al, 2013). Rhes …”

Section: Activators Of G Protein Signaling: Mechanistic and Functionamentioning

confidence: 99%

Activators of G Protein Signaling Exhibit Broad Functionality and Define a Distinct Core Signaling Triad

Blumer

Lanier

2014

Molecular Pharmacology

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“…It has been suggested that guanine nucleotide binding to AGS1 is required for its proper functioning [4]. AGS1 is widely expressed in the nervous system with rhythmic expression in suprachiasmatic nucleus (SCN) [13], the protein distribution pattern of AGS1 in the central nervous system (CNS) is summarized in table 2. AGS1 is regulated by the NMDA receptor and neuronal nitric oxide synthase (nNOS) [14] and it has been reported to play a role in circadian rhythm [15,16].…”

Section: Regulation Of Circadian Rhythm Via Ags1mentioning

confidence: 99%

Neuronal Functions of Activators of G Protein Signaling

Tse¹,

Wong²

2013

Neurosignals

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G protein-coupled receptors (GPCRs) are one of the most important gateways for signal transduction across the plasma membrane. Over the past decade, several classes of alternative regulators of G protein signaling have been identified and reported to activate the G proteins independent of the GPCRs. One group of such regulators is the activator of G protein signaling (AGS) family which comprises of AGS1-10. They have entirely different activation mechanisms for G proteins as compared to the classic model of GPCR-mediated signaling and confer upon cells new avenues of signal transduction. As GPCRs are widely expressed in our nervous system, it is believed that the AGS family plays a major role in modulating the G protein signaling in neurons. In this article, we will review the current knowledge on AGS proteins in relation to their potential roles in neuronal regulations.

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Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus

Cited by 69 publications

References 32 publications

The Molecular Gatekeeper Dexras1 Sculpts the Photic Responsiveness of the Mammalian Circadian Clock

The Molecular Gatekeeper Dexras1 Sculpts the Photic Responsiveness of the Mammalian Circadian Clock

Activators of G Protein Signaling Exhibit Broad Functionality and Define a Distinct Core Signaling Triad

Neuronal Functions of Activators of G Protein Signaling

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