Mouse mammary tumor virus production stimulated by hormones and polyamines in cells grown in semi‐synthetic <i>in vitro</i> conditions

Svec, J; Links, J.

doi:10.1002/ijc.2910190215

Cited by 13 publications

(7 citation statements)

References 21 publications

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“…In agreement with previous in vitro studies, these observations demonstrate that glucocorticoid treatment in vivo increased MuMTV RNA in mammary tumors from a strain that contains the exogenous MuMTV-S. The effect of prolactin on the level of MuMTV RNA in the BALB/ cfC3H mammary tumors may be consistent with the report that prolactin increased MuMTV production in the presence of glucocorticoid hormones (33).…”

Section: Resultssupporting

confidence: 92%

“…Similarly, MuMTV RNA in hormone-induced BALB/c mammary tumor cells in vitro was increased by glucocorticoid treatment (13). Although prolactin alone had no effect on MuMTV production in C3H tumor cells in vitro (4, 12, 33), it is not clear whether prolactin in combination with glucocorticoids increased MuMTV production (4,33). Optimal MuMTV production in vitro by mammary cells from midpregnant BALB/cfC3H glands was dependent upon both prolactin and glucocorticoids (37).…”

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confidence: 99%

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Hormonal regulation of murine mammary tumor virus RNA expression during mammary tumorigenesis in BALB/c mice

Pauley¹,

Medina²,

Socher³

1979

J Virol

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The effects of glucocorticoids and prolactin on murine mammary tumor virus (MuMTV) RNA expression in preneoplastic outgrowth lines and mammary tumors in BALB/c mice were investigated. Hyperplastic alveolar nodules (HAN) and a ductal hyperplasia (DH) are induced in virgin BALB/c mice by prolonged hormonal stimulation or treatment with 7,12-dimethylbenz(a)anthracene or both. Mice bearing HAN or DH outgrowth lines and mammary tumors that arose from the outgrowth lines were treated with glucocorticoids or prolactin. MuMTV RNA was quantitated by hybridization with a representative complementary DNA probe specific for MuMTV RNA. Prolactin treatment did not increase MuMTV RNA in the BALB/c HAN or DH outgrowth lines or tumors. MuMTV RNA increased after glucocorticoid treatment in the C3, C4, and C5 HAN outgrowth lines and in tumors that arose from the Dl, D2, C4, and C5 HAN and CD8 DH outgrowth lines. No increase in MuMTV RNA with glucocorticoid treatment was observed in the Dl or D2 HAN outgrowth line, in the CD8 DH outgrowth line, and in tumors that arose from the C3 HAN outgrowth line. The ability of glucocorticoids to stimulate MuMTV expression was specific since the response was dose dependent and specific for glucocorticoid hormones. Glucocorticoid treatment did not increase the level of type C viral RNA in the majority of hormoneor 7,12-dimethylbenz(a)anthracene-induced HAN outgrowth lines or tumors. These observations suggested that glucocorticoids may influence MuMTV expression during mammary tumorigenesis in BALB/c mice. Murine mammary tumorigenesis is a multistage process that is influenced by several factors, including the mouse mammary tumor virus (MuMTV), hormones, and carcinogens (1, 2,22). BALB/c mice, which have a low incidence of spontaneous mammary tumors (22), contain five to nine copies of the endogenous, germinally transmitted MuMTV per diploid cell (1, 21). MuMTV RNA was low or undetectable in BALB/c mammary glands from breeding females and in spontaneous mammary tumors (14, 26, 27). In contrast, glands and tumors from the high-tumor-incidence strain BALB/cfC3H, which contain an exogenous milk-transmitted virus designated MuMTV-S (1), had high amounts of MuMTV RNA (26, 27).

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Section: Resultssupporting

confidence: 92%

mentioning

confidence: 99%

Hormonal regulation of murine mammary tumor virus RNA expression during mammary tumorigenesis in BALB/c mice

Pauley¹,

Medina²,

Socher³

1979

J Virol

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“…The effect of prolactin in stimulating the MTV RNA ecpression in vivo seems similar to the action of glucocorticoids in vitro (19,21). In in vitro studies no effect on the MTV RNA expression has been observed by the addition of prolactin alone (19), but prolactin increased the MTV RNA expression in combination with dexamethasone and insulin (24).…”

Section: Resultsmentioning

confidence: 92%

Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains

Deemter¹,

Nusse²,

Röpcke³

et al. 1978

J Virol

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The involvement of the mouse mammary tumor virus (MTV) in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains was studied by comparing the amounts of MTV RNA and MTV DNA sequences in mammary tumors and other tissues of mice with an without hormonal treatments. The following results were obtained. (i) Mammary tumors which appeared in C3H mice as a result of an infection with MTV contained more MTV DNA compared with noninfected organs; these mammary tumors also contained more MTV RNA than was present in lactating mammary gland cells. (ii) Hormonal stimulation by administration of excessive amounts of prolactin via hypophyseal isografts in C3Hf and O20 mice resulted in an increased expression of MTV RNA in the mammary glands. This elevated level of MTV RNA expression was, however, not maintained in the hormone-induced mammary tumors. (iii) Spontaneous mammary tumors in BALB/c mice contained similar levels of MTV DNA and MTV RNA sequences as were found in other cells of these animals.

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“…The peptide hormone prolactin has been shown to enhance the effects of glucocorticoids on the expression of MMTV (Svec & Links, 1977). More recently it has been shown that prolactin at physiological concentrations may play a greater role in the control of MMTV expression in vivo than previously thought, particularly in parous mice (Munoz & Bolander, 1989).…”

Section: Prolactinmentioning

confidence: 99%

Factors controlling the expression of mouse mammary tumour virus

Günzburg

Salmons

1992

Biochemical Journal

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Mouse mammary tumor virus production stimulated by hormones and polyamines in cells grown in semi‐synthetic in vitro conditions

Cited by 13 publications

References 21 publications

Hormonal regulation of murine mammary tumor virus RNA expression during mammary tumorigenesis in BALB/c mice

Hormonal regulation of murine mammary tumor virus RNA expression during mammary tumorigenesis in BALB/c mice

Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains

Factors controlling the expression of mouse mammary tumour virus

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