Mouse Models for the Study of Borrelia burgdorferi Infection
Kimberly J. Olsen,
Shilpa Sachan,
Nicole Baumgarth
Abstract:Lyme disease, a tickborne illness caused by Borrelia burgdorferi, is an emerging, significant public health concern. B. burgdorferi infections are challenging to study because of their complex life cycle that requires adaptation to both ticks and mammalian hosts for long‐term survival and transmission. Bacterial adaptation is accomplished through extensive gene expression alterations in response to environmental cues that remain to be more fully explored. Mouse models of infection serve as valuable tools for s… Show more
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