Mouse Models of Mucormycosis

Jacobsen, Ilse D.

doi:10.1007/978-1-0716-3199-7_14

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…[57,58] Nonetheless, the majority of research employed mice or rabbits, and Table 2 provides a summary of the published studies that concentrate on these two host species. [59] The use of rats and mice as animal models for the study of the following parameters in the case of mucormycosis pathogenicity, virulence traits, comparative virulence, diagnosis, therapy, and vaccines. The important parameter is the route of infection because of the type of fungi infected on which organ and interaction with the host.…”

Section: Animal Models For Mucormycosis Studymentioning

confidence: 99%

Eye Bird View on Natural Plants in the Management of Mucormycosis

Patil,

Desai,

Tirgar

2024

Int. J. Pharm. Sci. Drug Res.

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Mucormycosis, also referred to as Zygomycosis, is chiefly caused by filamentous moulds belonging to the Mucorales group. It can be acquired through inhaling spores, consuming contaminated food, or through injury to the skin. Currently, the second most prevalent fungal infection disease is mucormycosis. It gained greatest attention following the COVID-19 pandemic. The review mainly focuses on several outlines like its history, epidemiology, pathophysiology, types, diagnosis and treatment of mucormycosis. In treatment of mucormycosis, conventional therapy against mucormycosis and some antifungal agents has been discussed. Several diverse contagious ailments were conventionally cured utilizing a widespread series of medicinal plants. Given that India is at the forefront of the Ayurvedic and Siddha medical systems, traditional herbal medicine from India is highly well-known. Antifungal chemicals derived from plants can be a viable option for developing novel and enhanced alternative formulations in the field of antifungal medicine. The main focus on the review is to explore the potential plants having the antifungal activity used for treatment of mucormycosis. Some of the plants with antifungal activity has been explained which includes garlic, tea tree oil, aloe vera, thyme, turmeric, neem, eucalyptus, clove, goldenseal, calendula, lavender, guduchi, and oregano. Animal models for mucormycosis study has been explained in the review.

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Section: Animal Models For Mucormycosis Studymentioning

confidence: 99%

Eye Bird View on Natural Plants in the Management of Mucormycosis

Patil,

Desai,

Tirgar

2024

Int. J. Pharm. Sci. Drug Res.

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Molecular mechanisms that govern infection and antifungal resistance in Mucorales

Lax,

Nicolás,

Navarro

et al. 2024

Microbiol Mol Biol Rev

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SUMMARY The World Health Organization has established a fungal priority pathogens list that includes species critical or highly important to human health. Among them is the order Mucorales, a fungal group comprising at least 39 species responsible for the life-threatening infection known as mucormycosis. Despite the continuous rise in cases and the poor prognosis due to innate resistance to most antifungal drugs used in the clinic, Mucorales has received limited attention, partly because of the difficulties in performing genetic manipulations. The COVID-19 pandemic has further escalated cases, with some patients experiencing the COVID-19-associated mucormycosis, highlighting the urgent need to increase knowledge about these fungi. This review addresses significant challenges in treating the disease, including delayed and poor diagnosis, the lack of accurate global incidence estimation, and the limited treatment options. Furthermore, it focuses on the most recent discoveries regarding the mechanisms and genes involved in the development of the disease, antifungal resistance, and the host defense response. Substantial advancements have been made in identifying key fungal genes responsible for invasion and tissue damage, host receptors exploited by the fungus to invade tissues, and mechanisms of antifungal resistance. This knowledge is expected to pave the way for the development of new antifungals to combat mucormycosis. In addition, we anticipate significant progress in characterizing Mucorales biology, particularly the mechanisms involved in pathogenesis and antifungal resistance, with the possibilities offered by CRISPR-Cas9 technology for genetic manipulation of the previously intractable Mucorales species.

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Review on Mucormycosis: Pathogenesis, Epidemiology, Microbiology and Diagnosis

Sharma,

Alam,

Dhoundiyal

et al. 2024

IDDT

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Mucormycosis is a serious and invasive fungal infection caused by Mucorales fungi. This review article provides a concise overview of the pathogenesis, epidemiology, microbiology, and diagnosis of mucormycosis. The introduction section highlights the key microbiological properties of the pathogen and delves into the underlying mechanisms of mucormycosis pathogenesis, including the invasion and proliferation of the fungus within the host. The description of the disease section focuses on the epidemiology of mucormycosis, including its incidence, risk factors, and geographical distribution. It also explores the specific context of mucormycosis infection about COVID-19 and diabetes mellitus, highlighting the increased susceptibility observed in individuals with these conditions. A case study illustrates the clinical manifestations and challenges associated with mucormycosis, emphasizing the importance of early detection. Additionally, the review discusses the diagnosis of mucormycosis, emphasizing the significance of clinical assessment, radiological imaging, and microbiological tests for accurate and timely detection of the infection. Regarding treatment, the article covers the various therapeutic approaches, including antifungal therapy, surgical interventions, and management of underlying predisposing conditions. The limitations and challenges associated with treatment options are also addressed. This review aims to provide a comprehensive understanding of mucormycosis, equipping healthcare professionals with valuable insights into its pathogenesis, epidemiology, microbiology, and diagnostic strategies. By enhancing knowledge and awareness of this fungal infection, this review can improve patient outcomes through early diagnosis and appropriate management.

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Mouse Models of Mucormycosis

Cited by 3 publications

References 28 publications

Eye Bird View on Natural Plants in the Management of Mucormycosis

Eye Bird View on Natural Plants in the Management of Mucormycosis

Molecular mechanisms that govern infection and antifungal resistance in Mucorales

Review on Mucormycosis: Pathogenesis, Epidemiology, Microbiology and Diagnosis

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