Mouse oocytes develop in cysts with the help of nurse cells

Niu, Wanbao; Spradling, Allan C.

doi:10.1016/j.cell.2022.05.001

Cited by 59 publications

(56 citation statements)

References 60 publications

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“…4c). The resultant Eya dynamics were then used as direct proxy for affinity dynamics, with row 7 dynamics being assigned to rows [7][8][9][10][11][12][13][14]. Simulating affinity based on measured Eya levels was sufficient to recapitulate FC behavior throughout development (Fig.…”

Section: Eya-controlled Affinity Dynamics Account For Fc Distribution...mentioning

confidence: 99%

“…From invertebrates to vertebrates, oocytes develop within a germline cyst that is enveloped by somatic cells 4 . The germline cyst consists of the oocyte itself and so-called nurse cells [5][6][7][8] . The role of nurse cells is to supply the oocyte with essential materials during oogenesis, but eventually, nurse cells are removed to generate a single mature oocyte 6,7,9 .…”

Section: Introductionmentioning

confidence: 99%

“…The germline cyst consists of the oocyte itself and so-called nurse cells [5][6][7][8] . The role of nurse cells is to supply the oocyte with essential materials during oogenesis, but eventually, nurse cells are removed to generate a single mature oocyte 6,7,9 . The maturation of the oocyte, as well as the removal of nurse cells is strictly dependent on the cooperation with somatic cells enveloping the germline cyst.…”

Section: Introductionmentioning

confidence: 99%

“…The maturation of the oocyte, as well as the removal of nurse cells is strictly dependent on the cooperation with somatic cells enveloping the germline cyst. These socalled follicle cells (FCs) differentiate into diverse cell fates, which, among others, specialize to facilitate oocyte maturation by eggshell secretion or nurse cell removal by phagoptosis 4,7,[9][10][11][12] . Thus, it is essential that germline cells and somatic cells match each other, such that nurse cells are in contact with FCs that facilitate nurse cell removal, and the oocyte is in contact with FCs that enable oocyte maturation.…”

Section: Introductionmentioning

confidence: 99%

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Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis

Classen

Weichselberger

Dondl

2022

Preprint

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Cooperative morphogenesis of cell lineages underlies the development of functional units and organs. To study mechanisms driving the coordination of lineages, we investigated soma-germline interactions during oogenesis. From invertebrates to vertebrates, oocytes develop as part of a germline cyst that consists of the oocyte itself and so-called nurse cells, which feed the oocyte and are eventually removed. The enveloping somatic cells specialize to facilitate either oocyte maturation or nurse cell removal, which makes it essential to establish the right match between germline and somatic cells. We uncover that the transcriptional regulator Eya, expressed in the somatic lineage, controls bilateral cell-cell affinity between germline and somatic cells in Drosophila oogenesis. Employing functional studies and mathematical modelling, we show that differential affinity and the resulting forces drive somatic cell redistribution over the germline surface and control oocyte growth to match oocyte and nurse cells with their respective somatic cells. Thus, our data demonstrate that differential affinity between cell lineages is sufficient to drive the complex assembly of inter-lineage functional units and underlies tissue self-organization during Drosophila oogenesis.

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Section: Eya-controlled Affinity Dynamics Account For Fc Distribution...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis

Classen

Weichselberger

Dondl

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The germline cyst consists of the oocyte itself and so-called nurse cells 5 – 8 . The role of nurse cells is to supply the oocyte with essential materials during oogenesis, but eventually, nurse cells are removed to generate a single mature oocyte 6 , 7 , 9 . The maturation of the oocyte, as well as the removal of nurse cells is strictly dependent on the cooperation with somatic cells enveloping the germline cyst.…”

Section: Introductionmentioning

confidence: 99%

Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis

2022

View full text Add to dashboard Cite

Cooperative morphogenesis of cell lineages underlies the development of functional units and organs. To study mechanisms driving the coordination of lineages, we investigated soma-germline interactions during oogenesis. From invertebrates to vertebrates, oocytes develop as part of a germline cyst that consists of the oocyte itself and so-called nurse cells, which feed the oocyte and are eventually removed. The enveloping somatic cells specialize to facilitate either oocyte maturation or nurse cell removal, which makes it essential to establish the right match between germline and somatic cells. We uncover that the transcriptional regulator Eya, expressed in the somatic lineage, controls bilateral cell–cell affinity between germline and somatic cells in Drosophila oogenesis. Employing functional studies and mathematical modelling, we show that differential affinity and the resulting forces drive somatic cell redistribution over the germline surface and control oocyte growth to match oocyte and nurse cells with their respective somatic cells. Thus, our data demonstrate that differential affinity between cell lineages is sufficient to drive the complex assembly of inter-lineage functional units and underlies tissue self-organization during Drosophila oogenesis.

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Epigenetic programming in the ovarian reserve

Schultz

Namekawa

2023

BioEssays

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The ovarian reserve defines female reproductive lifespan, which in humans spans decades. The ovarian reserve consists of oocytes residing in primordial follicles arrested in meiotic prophase I and is maintained independent of DNA replication and cell proliferation, thereby lacking stem cell‐based maintenance. Largely unknown is how cellular states of the ovarian reserve are established and maintained for decades. Our recent study revealed that a distinct chromatin state is established during ovarian reserve formation in mice, uncovering a novel window of epigenetic programming in female germline development. We showed that an epigenetic regulator, Polycomb Repressive Complex 1 (PRC1), establishes a repressive chromatin state in perinatal mouse oocytes that is essential for prophase I‐arrested oocytes to form the ovarian reserve. Here we discuss the biological roles and mechanisms underlying epigenetic programming in ovarian reserve formation, highlighting current knowledge gaps and emerging research areas in female reproductive biology.

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Mouse oocytes develop in cysts with the help of nurse cells

Cited by 59 publications

References 60 publications

Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis

Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis

Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis

Epigenetic programming in the ovarian reserve

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