Mouse Peptidoglycan Recognition Protein PGLYRP-1 Plays a Role in the Host Innate Immune Response against<i>Listeria monocytogenes</i>Infection

Osanai, Arihiro; Sashinami, Hiroshi; Asano, Kozo; Li, Shengjun; Hu, Dong‐Liang; Nakane, Akio

doi:10.1128/iai.00466-10

Cited by 36 publications

(23 citation statements)

References 62 publications

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“…Infection episodes during HD significantly associated with higher salivary levels of PGLYRP1, suggesting that selected salivary biomarkers may indicate ongoing systemic infection in dialysis patients. Although the main, physiological functions of PGLYRP1 are still ambiguous, PGLYRP1 can be induced in response to systemic infection (Osanai et al, ). Recent work by Silbereisen et al demonstrated that the levels of PGLYRP1 were upregulated in saliva in response to experimental dental plaque accumulation (Silbereisen et al, ).…”

Section: Discussionmentioning

confidence: 99%

The relationship between oral diseases and infectious complications in patients under dialysis

et al. 2020

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Objectives Association was investigated between oral health before dialysis and the incidence of systemic infections during dialysis. We hypothesized that low‐grade systemic inflammation caused by poor oral health associates with infectious episodes in patients on dialysis, despite earlier eradication of oral infection foci. Subjects and methods A total of 117 patients (46 with peritoneal and 71 with hemodialysis) were examined and treated at predialysis stage and followed up during dialysis. Number of infection episodes and microorganisms cultured from blood and peritoneal fluid were analyzed. Number of teeth, periodontal inflammatory burden, and total dental index scores were assessed, and salivary matrix metalloproteinase 8, triggering receptor on myeloid cells 1, peptidoglycan recognition protein 1 (PGLYRP1), and interleukin‐1β were measured. Results In hemodialysis, 134 infection episodes were recorded, while peritoneal dialysis group had 77 peritonitis episodes. Culture‐negative samples were 69% in hemodialysis and 23% in peritoneal dialysis group. Staphylococci were the most frequently associated microorganisms. Infections during dialysis did neither associate with oral health parameters nor associate with salivary inflammatory biomarkers, except for PGLYRP1, which associated with number of infection episodes during hemodialysis (p = .046). Conclusions A number of infection episodes during hemodialysis were associated with salivary PGLYRP1 but not the other salivary markers or oral infection markers.

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Section: Discussionmentioning

confidence: 99%

The relationship between oral diseases and infectious complications in patients under dialysis

et al. 2020

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“…Another example of novel mediators in human EOS is PGLYRP1 or PGRP-S (also called Tag7), which recognizes bacterial peptidoglycan and has an antibacterial function [44]. PGLYRP1 is a 21Kd protein with a signal peptide for secretion.…”

Section: Discussionmentioning

confidence: 99%

Identification of Genes Expressed by Human Airway Eosinophils after an In Vivo Allergen Challenge

et al. 2013

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BackgroundThe mechanism for the contribution of eosinophils (EOS) to asthma pathophysiology is not fully understood. Genome-wide expression analysis of airway EOS by microarrays has been limited by the ability to generate high quality RNA from sufficient numbers of airway EOS.ObjectiveTo identify, by genome-wide expression analyses, a compendium of expressed genes characteristic of airway EOS following an in vivo allergen challenge.MethodsAtopic, mild asthmatic subjects were recruited for these studies. Induced sputum was obtained before and 48h after a whole lung allergen challenge (WLAC). Individuals also received a segmental bronchoprovocation with allergen (SBP-Ag) 1 month before and after administering a single dose of mepolizumab (anti-IL-5 monoclonal antibody) to reduce airway EOS. Bronchoalveolar lavage (BAL) was performed before and 48 h after SBP-Ag. Gene expression of sputum and BAL cells was analyzed by microarrays. The results were validated by qPCR in BAL cells and purified BAL EOS.ResultsA total of 299 transcripts were up-regulated by more than 2-fold in total BAL cells following SBP-Ag. Mepolizumab treatment resulted in a reduction of airway EOS by 54.5% and decreased expression of 99 of the 299 transcripts. 3 of 6 post-WLAC sputum samples showed increased expression of EOS-specific genes, along with the expression of 361 other genes. Finally, the intersection of the 3 groups of transcripts (increased in BAL post SBP-Ag (299), decreased after mepolizumab (99), and increased in sputum after WLAC (365)) was composed of 57 genes characterizing airway EOS gene expression.ConclusionWe identified 57 genes that were highly expressed by BAL EOS compared to unseparated BAL cells after in vivo allergen challenge. 41 of these genes had not been previously described in EOS and are thus potential new candidates to elucidate EOS contribution to airway biology.

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“…Peptidoglycan recognition protein (PGLRP)-1 (encoded by Pglyrp1 , also known as PGRP-S) is an innate pattern recognition protein that binds to bacterial peptidoglycan, and is expressed highly by M cells 8 . Little is known of the in vivo functions of the four mammalian PGLRPs, but PGLRP1 has bactericidal activity against Gram-positive bacteria and is not known to be involved in cell-signalling 50 . Whether the PGLRP1 secreted by M cells exhibits a similar bactericidal activity to help protect the host against internalized bacteria remains to be determined?…”

Section: Introductionmentioning

confidence: 99%

Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium

et al. 2013

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SUMMARY The transcytosis of antigens across the gut epithelium by microfold cells (M cells) is important for the induction of efficient immune responses to some mucosal antigens in Peyer’s patches. Recently, substantial progress has been made in our understanding of the factors that influence the development and function of M cells. This review highlights these important advances, with particular emphasis on: the host genes which control the functional maturation of M cells; how this knowledge has led to the rapid advance in our understanding of M-cell biology in the steady-state and during aging; molecules expressed on M cells which appear to be used as “immunosurveillance” receptors to sample pathogenic microorganisms in the gut; how certain pathogens appear to exploit M cells to infect the host; and finally how this knowledge has been used to specifically target antigens to M cells to attempt to improve the efficacy of mucosal vaccines.

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Mouse Peptidoglycan Recognition Protein PGLYRP-1 Plays a Role in the Host Innate Immune Response againstListeria monocytogenesInfection

Cited by 36 publications

References 62 publications

The relationship between oral diseases and infectious complications in patients under dialysis

The relationship between oral diseases and infectious complications in patients under dialysis

Identification of Genes Expressed by Human Airway Eosinophils after an In Vivo Allergen Challenge

Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium

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