Mouse preantral follicle growth in 3D co-culture system using human menstrual blood mesenchymal stem cell

Rajabi, Zahra; Yazdekhasti, Hossein; Mugahi, Seyed Mohammad Hossein Noori; Abbasi, Mehdi; Kazemnejad, Somaieh; Shirazi, Abolfazl; Majidi, Masoumeh; Zarnani, Amir‐Hassan

doi:10.1016/j.repbio.2018.02.001

Cited by 29 publications

(18 citation statements)

References 80 publications

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“…Similarly, in vitro, MenSC increased indices of mouse follicular growth, including survival rate, diameter and antrum formation, Bmp15 and Gdf9 expression and maturation rate in a 3D culture system. Secreted progesterone and estradiol increased in co-cultured murine preantral follicles and human MenSC implying a supportive role of MenSCs in follicle development, growth and maturation (Rajabi et al, 2018). In a recent clinical trial in 15 women, intraovarian injection of autologous MenSC in poor ovarian responders increased clinical pregnancy and live births (Zafardoust et al, 2020).…”

Section: Ovarian Function and Reservementioning

confidence: 94%

Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application

Bozorgmehr

Gurung

Darzi

et al. 2020

Front. Cell Dev. Biol.

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147

116

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Section: Ovarian Function and Reservementioning

confidence: 94%

Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application

Bozorgmehr

Gurung

Darzi

et al. 2020

Front. Cell Dev. Biol.

Self Cite

147

116

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“…190 Human menstrual blood-derived endometrial MSCs increased follicular growth and IVM rates when cocultured with mouse alginate-encapsulated preantral follicles. 191 In the same way, coculture of BMSCs with human alginate-encapsulated follicles improved follicle growth and viability in a dose-dependent manner, suggesting that the number of MSCs influences culture outcomes. 192…”

Section: Use Of Stem Cells To Improve Follicle Ivmmentioning

confidence: 85%

<p>Role of stem cells in fertility preservation: current insights</p>

Vermeulen¹,

Giudice²,

Vento³

et al. 2019

SCCAA

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While improvements made in the field of cancer therapy allow high survival rates, gonadotoxicity of chemo- and radiotherapy can lead to infertility in male and female pre- and postpubertal patients. Clinical options to preserve fertility before starting gonadotoxic therapies by cryopreserving sperm or oocytes for future use with assisted reproductive technology (ART) are now applied worldwide. Cryopreservation of pre- and postpubertal ovarian tissue containing primordial follicles, though still considered experimental, has already led to the birth of healthy babies after autotransplantation and is performed in an increasing number of centers. For prepubertal boys who do not produce gametes ready for fertilization, cryopreservation of immature testicular tissue (ITT) containing spermatogonial stem cells may be proposed as an experimental strategy with the aim of restoring fertility. Based on achievements in nonhuman primates, autotransplantation of ITT or testicular cell suspensions appears promising to restore fertility of young cancer survivors. So far, whether in two- or three-dimensional culture systems, in vitro maturation of immature male and female gonadal cells or tissue has not demonstrated a capacity to produce safe gametes for ART. Recently, primordial germ cells have been generated from embryonic and induced pluripotent stem cells, but further investigations regarding efficiency and safety are needed. Transplantation of mesenchymal stem cells to improve the vascularization of gonadal tissue grafts, increase the colonization of transplanted cells, and restore the damaged somatic compartment could overcome the current limitations encountered with transplantation.

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“…Although the use of these stem cells for cell therapy has been criticized and vigorously challenged by some researchers, HuMenSCs transplantation has been used to treat irreversible genetic disorders such as muscular dystrophies, diabetes, heart failure, and spinal cord injury. As a source of mesenchymal stem cells (MSCs), HuMenSCs have several interesting features, including their ability to grow rapidly, and are minimally invasive and safe for autologous transplantation (Gargett, ; Hida et al, ; Lin et al, ; Meng et al, ; Patel et al, ; Rajabi et al, ; Santamaria, Massasa, Feng, Wolff, & Taylor, ). HuMenSCs can also be induced to differentiate into specific tissue or organ‐like cells.…”

Section: Discussionmentioning

confidence: 99%

The effects of human menstrual blood stem cells‐derived granulosa cells on ovarian follicle formation in a rat model of premature ovarian failure

Manshadi

Navid

Hoshino

et al. 2018

Microscopy Res & Technique

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Many studies have reported that human endometrial mesenchymal stem cells (HuMenSCs) are capable of repairing damaged tissues. The aim of the present study was to investigate the effects of HuMenSCs transplantation as a treatment modality in premature ovarian failure (POF) associated with chemotherapy‐induced ovarian damage. HuMenSCs were isolated from menstrual blood samples of five women. After the in vitro culture of HuMenSCs, purity of the cells was assessed by cytometry using CD44, CD90, CD34, and CD45 FITC conjugate antibody. Twenty‐four female Wistar rats were randomly divided into four groups: negative control, positive control, sham, and treatment groups. The rat models of POF used in our study were established by injecting busulfan intraperitoneally into the rats during the first estrus cycle. HuMenSCs were transplanted by injection via the tail vein into the POF‐induced rats. Four weeks after POF induction, ovaries were collected and the levels of Amh, Fst, and Fshr expression in the granulosa cell (GC) layer, as well as plasma estradiol (E2) and progesterone (P4) levels were evaluated. Moreover, migration and localization of DiI‐labeled HuMenSCs were detected, and the labeled cells were found to be localized in GCs layer of immature follicles. In addition to DiI‐labelled HuMenSCs tracking, increased levels of expression of Amh and Fshr and Fst, and the high plasma levels of E2 and P4 confirmed that HuMenSC transplantation had a significant effect on follicle formation and ovulation in the treatment group compared with the negative control (POF) group.

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Mouse preantral follicle growth in 3D co-culture system using human menstrual blood mesenchymal stem cell

Cited by 29 publications

References 80 publications

Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application

Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application

<p>Role of stem cells in fertility preservation: current insights</p>

The effects of human menstrual blood stem cells‐derived granulosa cells on ovarian follicle formation in a rat model of premature ovarian failure

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