Mouse susceptibility to infection by theSalmonella abortusovisvaccine strain Rv6 is controlled by theIty/Nramp 1gene and influences the antibody but not the complement responses

Cross-protection of Salmonella abortusovis, S. choleraesuis, S. dublin and S. gallinarum in mice induced by S. abortusovis and S. gallinarum: bacteriology and humoral immune response

“…The NRAMP1 protein directly or indirectly regulates many events in macrophage cells [44,48]. Recent studies have demonstrated that the expression of this gene influences not only bacterial multiplication but also humoral [14] and cellular [6] immune response, from the interaction with the bacterial lipopolysaccharide (LPS) [26] to the cascade of cytokines, [4,9,38], through Ag processing [22]. Thus, host genetics might also have an influence on the ability to induce a protective immune response to recombinant vaccine.…”

“…C.CB mice were selected and bred in our lab. Since numerous works have been carried out on mice which are susceptible and resistant to Typhimurium, few have been conducted on Abortusovis [3,14,32], Dublin [9,23,42,46], Choleraesuis [10] and Gallinarum [34]. It is clear that during the first phase of infection three possibilities arise: (a) a continuous increase of bacteria in the spleen of infected Salmonella cross-protection in mice 65 mice, (b) an increase, plateau phase and decrease of bacteria and (c) a continuous decrease of bacteria.…”

“…Resistant ity r mice were chosen in order not to kill all the animals injected. Through recent studies it has been demonstrated that this gene has pleiotropic effects on the humoral and cellular immune response [14,32,38]. Humoral IgM and IgG antibody immune response was assessed against bacterial antigens specific for the Salmonella used to prime or to challenge the animals.…”

Quantitative trait loci for resistance to infection in sheep using a live Salmonella Abortusovis vaccine

“…We also measured antibody response, which is related to active immunity to Salmonella [reviewed by Mastroeni et al. (2001)] and is correlated with SAO load in both mice (Gautier et al. 1998) and sheep (Moreno et al.…”

“…2007). As IL‐4 and IL‐5 are involved in initiating the antibody response in the B‐cell follicles from lymph nodes, polymorphisms associated with these genes could influence antibody‐mediated bacterial killing (Gautier et al. 1998).…”