Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry

Lambers, Floor M.; Schulte, Friederike A.; Kuhn, Gisela; Webster, Duncan J.; Müller, Ralph

doi:10.1016/j.bone.2011.08.035

Cited by 106 publications

(105 citation statements)

References 65 publications

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“…Osteocytes in the bone are capable of sensing local tissue loading and are thus considered to trigger bone adaptation according to mechanical loading. This process strives to create a state where all bone tissue is loaded as uniformly as possible in order to avoid peak loads and unnecessary weight (Barak et al 2011;Lambers et al 2011;Pontzer et al 2006;Roux 1881;Schulte et al 2013;Sugiyama et al 2012Sugiyama et al , 2010Wolff 1892). The formfunction relationship due to bone adaptation implies that it might be possible as well to reversely derive hip-joint loading patterns from the femoral head microstructure by finding a set of joint forces that produce such a state of uniform tissue loading.…”

Section: Introductionmentioning

confidence: 99%

Determination of hip-joint loading patterns of living and extinct mammals using an inverse Wolff’s law approach

Christen

Ito

Galis

et al. 2014

Biomech Model Mechanobiol

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Section: Introductionmentioning

confidence: 99%

Determination of hip-joint loading patterns of living and extinct mammals using an inverse Wolff’s law approach

Christen

Ito

Galis

et al. 2014

Biomech Model Mechanobiol

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“…To our knowledge, ovariectomy-induced bone loss has not been investigated in caudal vertebrae of mice. However, it would be very convenient if, instead of the distal femur, a caudal vertebra could be used as an osteoporosis model because this would have several advantages: (1) it is more easily accessible for high-resolution imaging, (2) the whole bone can be imaged within an acceptable scan time and dose, (3) both cortical and trabecular bone can be imaged, (4) the amount of trabecular bone is relatively high in vertebrae, and (5) it is accessible for mechanical loading [20,21].…”

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confidence: 99%

Longitudinal Assessment of In Vivo Bone Dynamics in a Mouse Tail Model of Postmenopausal Osteoporosis

et al. 2011

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Recently, it has been shown that transient bone biology can be observed in vivo using time-lapse microcomputed tomography (lCT) in the mouse tail bone. Nevertheless, in order for the mouse tail bone to be a model for human disease, the hallmarks of any disease must be mimicked. The aim of this study was to investigate whether postmenopausal osteoporosis could be modeled in caudal vertebrae of C57Bl/6 mice, considering static and dynamic bone morphometry as well as mechanical properties, and to describe temporal changes in bone remodeling rates. Twenty C57Bl/6 mice were ovariectomized (OVX, n = 11) or sham-operated (SHM, n = 9) and monitored with in vivo lCT on the day of surgery and every 2 weeks after, up to 12 weeks. There was a significant decrease in bone volume fraction for OVX (-35%) compared to SHM (?16%) in trabecular bone (P \ 0.001). For OVX, highturnover bone loss was observed, with the bone resorption rate exceeding the bone formation rate (P \ 0.001). Furthermore there was a significant decrease in whole-bone stiffness for OVX (-16%) compared to SHM (?11%, P \ 0.001). From these results we conclude that the mouse tail vertebra mimics postmenopausal bone loss with respect to these parameters and therefore might be a suitable model for postmenopausal osteoporosis. When evaluating temporal changes in remodeling rates, we found that OVX caused an immediate increase in bone resorption rate (P \ 0.001) and a delayed increase in bone formation rate (P \ 0.001). Monitoring transient bone biology is a promising method for future research.

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“…Recently, a new method was developed that allows monitoring sites of bone formation and bone resorption from time-lapsed in vivo micro-CT images 55 using unprecedented resolution. Nevertheless, this method allows monitoring longitudinal changes in bone formation and resorption rates induced by mechanical loading 56 and bone regeneration. 57 …”

Section: Time-lapsed Imaging Of Bone Remodeling Activitymentioning

confidence: 99%

“…Changes in bone remodeling rates were mostly an effect of changes in the surface occupied and not thickness of remodeling sites, whereas the amount of remodeling sites was not different from control group, indicating that the osteoblast and osteoclast activity were modulated rather than the osteoblast and osteoclast number. 56 Although only one scanner was used in this study, it can be regarded as a multi-modality approach, because both anatomical and functional parameters were extracted. Fatigue loading response.…”

Section: Applications Of Multimodality Molecular Imaging In Bone Resementioning

confidence: 99%

Advances in multimodality molecular imaging of bone structure and function

2012

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The skeleton is important to the body as a source of minerals and blood cells and provides a structural framework for strength, mobility and the protection of organs. Bone diseases and disorders can have deteriorating effects on the skeleton, but the biological processes underlying anatomical changes in bone diseases occurring in vivo are not well understood, mostly due to the lack of appropriate analysis techniques. Therefore, there is ongoing research in the development of novel in vivo imaging techniques and molecular markers that might help to gain more knowledge of these pathological pathways in animal models and patients. This perspective provides an overview of the latest developments in molecular imaging applied to bone. It emphasizes that multimodality imaging, the combination of multiple imaging techniques encompassing different image modalities, enhances the interpretability of data, and is imperative for the understanding of the biological processes and the associated changes in bone structure and function relationships in vivo .

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Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry

Cited by 106 publications

References 65 publications

Determination of hip-joint loading patterns of living and extinct mammals using an inverse Wolff’s law approach

Determination of hip-joint loading patterns of living and extinct mammals using an inverse Wolff’s law approach

Longitudinal Assessment of In Vivo Bone Dynamics in a Mouse Tail Model of Postmenopausal Osteoporosis

Advances in multimodality molecular imaging of bone structure and function

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