2014
DOI: 10.1016/j.schres.2014.09.031
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Movement abnormalities predict transitioning to psychosis in individuals at clinical high risk for psychosis

Abstract: Improving upon the predictive validity of determining the transition from high risk to actual psychosis is a primary aim of early intervention research. Previous research has suggested that premorbid spontaneous dyskinesias may be one possible predictor. In this study, dyskinetic movements were assessed with the Abnormal Involuntary Movement Scale (AIMS) at baseline of a longitudinal study of 148 individuals at clinical high risk (CHR) of developing psychosis. Twenty-eight individuals transitioned to a psychot… Show more

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Cited by 47 publications
(36 citation statements)
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“…Indeed, relevant research in UHR and first episode psychosis patients also shows that motor function associated with neurologic soft sign exams and spontaneous Parkinsonisms predict cognitive impairment and worsening negative symptoms (Cuesta et al, 2014; Dean and Mittal, 2014; Mittal et al, 2014). In contrast to the current results, hyperkinetic movements (e.g., dyskinesias) appear to be more closely linked to aberrant dopaminergic processes and predict exacerbation of positive symptoms (Callaway et al, 2014; Mittal et al, 2010; Mittal et al, 2008; Mittal et al, 2007). …”
Section: Discussioncontrasting
confidence: 99%
“…Indeed, relevant research in UHR and first episode psychosis patients also shows that motor function associated with neurologic soft sign exams and spontaneous Parkinsonisms predict cognitive impairment and worsening negative symptoms (Cuesta et al, 2014; Dean and Mittal, 2014; Mittal et al, 2014). In contrast to the current results, hyperkinetic movements (e.g., dyskinesias) appear to be more closely linked to aberrant dopaminergic processes and predict exacerbation of positive symptoms (Callaway et al, 2014; Mittal et al, 2010; Mittal et al, 2008; Mittal et al, 2007). …”
Section: Discussioncontrasting
confidence: 99%
“…Movement abnormalities tied to aberrant neurodevelopment have been proposed to be a key sign of risk for psychosis (Callaway et al, 2014; Dean and Mittal, 2015; Dean et al, 2013; Mittal et al, 2010a; Mittal et al, 2007a; Mittal et al, 2008; Mittal et al, 2007b). However, to date, our understanding of laterality during this critical period has been limited.…”
Section: Discussionmentioning
confidence: 99%
“…42 In support of this theory, prospective investigations in youth with prodromal syndromes have observed that the presence of specific motor abnormalities significantly increases the odds of developing psychosis in a brief 2-year period. 10,43 In a new exciting direction, some work also suggests that cerebellar-specific motor behavior (i.e., balance) may also have unique predictive value for negative symptoms as well. 29,44 This series of findings has significant practical use for the refinement of risk calculators 45 as well as efforts to understand unique potential subtypes.…”
Section: At Issuementioning
confidence: 99%