Movement and VIP Interneuron Activation Differentially Modulate Encoding in Mouse Auditory Cortex

Bigelow, James H.; Morrill, Ryan J.; DeKloe, Jefferson; Hasenstaub, Andrea R.

doi:10.1523/eneuro.0164-19.2019

Cited by 61 publications

(96 citation statements)

References 66 publications

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“…Moreover our mapping of the efferent targets of VIP+ IN reinforce the body of evidence showing that this class of neuron target pyramidal cells directly (Chiu et al, 2018;Garcia-Junco-Clemente et al, 2017;Lee et al, 2013;Pfeffer et al, 2013) and do so from an early age. As such VIP+ INs are, from the moment that they integrate into neocortex, well positioned to exert varied effects as described in the juvenile and adult cortex (Batista-Brito et al, 2017;Bigelow et al, 2019;Cardin, 2019;Dipoppa et al, 2018;Fu et al, 2014;Garrett et al, 2020;Keller et al, 2020;Millman et al, 2019;Pakan et al, 2016;Pi et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Ontogeny of the VIP+ interneuron sensory-motor circuit prior to active whisking

Vagnoni

Baruchin

Ghezzi

et al. 2020

Preprint

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ABSTRACTDevelopment of the cortical circuits for sensory-motor processing require the coordinated integration of both columnar and long-range synaptic connections. To understand how this occurs at the level of individual neurons we have explored the timeline over which vasoactive intestinal peptide (VIP)-expressing interneurons integrate into mouse somatosensory cortex. We find a distinction in emergent long-range anterior-motor and columnar glutamatergic inputs onto layer (L)2 and L3 VIP+ interneurons respectively. In parallel, VIP+ interneurons form efferent connections onto both pyramidal cells and interneurons in the immediate column in an inside-out manner. Cell-autonomous deletion of the fate-determinant transcription factor, Prox1, spares long-range anterior-motor inputs onto VIP+ interneurons, but leads to deficits in local connectivity. This imbalance in the somatosensory circuit results in altered spontaneous and sensory-evoked cortical activity in vivo. This identifies a critical role for VIP+ interneurons, and more broadly interneuron heterogeneity, in formative circuits of neocortex.

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Section: Discussionmentioning

confidence: 99%

Ontogeny of the VIP+ interneuron sensory-motor circuit prior to active whisking

Vagnoni

Baruchin

Ghezzi

et al. 2020

Preprint

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“…However, the computation of the extra-classical receptive fields need not be intrinsically limited to simple cells responding to Gabor-like filters, but can be extended to encompass neurons responding to more complex features in areas beyond V1. Switching circuits can occur more generally, including in somatosensory and auditory cortices, where some of the same neuronal populations interact using similar circuit logic [44,6]. Populations of neurons in general switching circuits can respond to diverse stimuli (e.g.…”

Section: Discussionmentioning

confidence: 99%

Single circuit in V1 capable of switching contexts during movement using VIP population as a switch

Voina

Recanatesi

et al. 2020

Preprint

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As animals adapt to their environments, their brains are tasked with processing stimuli in different sensory contexts. Whether these computations are context dependent or independent, they are all implemented in the same neural tissue. A crucial question is what neural architectures can respond flexibly to a range of stimulus conditions and switch between them. This is a particular case of flexible architecture that permits multiple related computations within a single circuit.Here, we address this question in the specific case of the visual system circuitry, focusing on context integration, defined as the integration of feedforward and surround information across visual space. We show that a biologically inspired microcircuit with multiple inhibitory cell types can switch between visual processing of the static context and the moving context. In our model, the VIP population acts as the switch and modulates the visual circuit through a disinhibitory motif. Moreover, the VIP population is efficient, requiring only a relatively small number of neurons to switch contexts. This circuit eliminates noise in videos by using appropriate lateral connections for contextual spatio-temporal surround modulation, having superior denoising performance compared to circuits where only one context is learned. Our findings shed light on a minimally complex architecture that is capable of switching between two naturalistic contexts using few switching units.Author SummaryThe brain processes information at all times and much of that information is context-dependent. The visual system presents an important example: processing is ongoing, but the context changes dramatically when an animal is still vs. running. How is context-dependent information processing achieved? We take inspiration from recent neurophysiology studies on the role of distinct cell types in primary visual cortex (V1).We find that relatively few “switching units” — akin to the VIP neuron type in V1 in that they turn on and off in the running vs. still context and have connections to and from the main population — is sufficient to drive context dependent image processing. We demonstrate this in a model of feature integration, and in a test of image denoising. The underlying circuit architecture illustrates a concrete computational role for the multiple cell types under increasing study across the brain, and may inspire more flexible neurally inspired computing architectures.

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“…The stimulating effect of motor inputs on VIP interneurons is well established also in V1 (Polack et al, 2013;Fu et al, 2014;Jackson et al, 2016;Pakan et al, 2016;Dipoppa et al, 2018). In contrast, activation of VIP interneurons in A1 during locomotion disrupts their sophisticated contribution to stimuli processing (Bigelow et al, 2019).…”

Section: Role Of Vip Interneurons In Information Processing Within Comentioning

confidence: 98%

Updating the picture of layer 2/3 VIP-expressing interneuron function in the mouse cerebral cortex

Posluszny¹

2020

Acta Neurobiologiae Experimentalis

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For years, interneurons expressing vasoactive intestinal peptide (VIP) interneurons and their function within the neocortex have been shrouded in mystery. Their relatively small size and minimal representation in the cortex have made investigation difficult. Due to their service role performed in co-operation with glia and blood vessels to supply energy during neuronal activation in the brain, the contribution of VIP interneurons to local neuronal circuit function was not appreciated. VIP interneurons in the neocortex account for roughly 12% of all interneurons. They have been described as a subgroup of the third largest population of 5-hydroxytryptamine 3a (5HT3a) receptor-expressing interneurons, non-overlapping with interneuron populations expressing parvalbumin (PV) or somatostatin (SST). However, it was recently shown that only half of VIP interneurons display a 5HT3a receptor response and a subset of VIP interneurons in visual cortex co-express SST. Over the last several years, due to new technical advancements, many facts have emerged relating to VIP interneuron phylogenetic origin, operational mechanisms within local circuits and functional significance. Some of these discoveries have dramatically shifted the perception of VIP interneurons. This review focuses on the function of the VIP interneurons residing in layer 2/3 of the mouse neocortex.

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Movement and VIP Interneuron Activation Differentially Modulate Encoding in Mouse Auditory Cortex

Abstract: Visual Abstract

Cited by 61 publications

References 66 publications

Ontogeny of the VIP+ interneuron sensory-motor circuit prior to active whisking

Ontogeny of the VIP+ interneuron sensory-motor circuit prior to active whisking

Single circuit in V1 capable of switching contexts during movement using VIP population as a switch

Updating the picture of layer 2/3 VIP-expressing interneuron function in the mouse cerebral cortex

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