“…An important difference between DRD and EOPD is the presence, in DRD, of diurnal fluctuation (aggravation of symptoms toward the evening and alleviation of symptoms in the morning after sleep), a dramatic and sustained response (complete or near-complete responsiveness of symptoms) to relatively low doses of orally administered Levodopa and absence of motor adverse effects of long-term Levodopa therapy (wearing-off and on-off phenomena and Dopainduced dyskinesias) under optimal doses of Levodopa [5].…”