Movement disorders associated with antiseizure medications: A systematic review

A Case of Oral-Buccal-Lingual Dyskinesia and Neuropsychiatric Symptoms After Prolonged Levetiracetam Exposure

“…Despite being outlined in the medication's package insert related to post-marketing experience [11], there is limited literature on the dyskinetic effects of levetiracetam. One prior case report described levetiracetam-induced chorea in a 28year-old woman with seizures from brain metastasis attributed to spinal cord glioblastoma, which resolved upon switching from levetiracetam to a combination of lorazepam and phenytoin [8], and there is also contrary evidence where levetiracetam was effective in reducing TD that was developed from chronic neuroleptic use [9]. Elderly or people with preexisting mental illnesses may be more prone to neuropsychiatric side effects including dyskinesia from levetiracetam, but there is no evidence necessitating further research.…”

“…Although generally well-tolerated, antiepileptic drugs such as levetiracetam have rarely been associated with various movement disorders such as tremors, ataxia, and dyskinesias [8,9]. We present a case of oralbuccal-lingual dyskinesia and neuropsychiatric symptoms in an elderly female with a long history of levetiracetam-treated seizure disorder that resolves after the discontinuation of levetiracetam.…”

Phenomenology of Tremor In 48,XXYY Syndrome: A Case Report

“…Additionally, it is unlikely for phenobarbital to be a cause for tremor, because no associations have been reported so far. 9 Moreover, testosterone administration has been reported to improve tremor in Klinefelter's syndrome. 10 There is also little evidence on treatment of tremor in 48,XXYY (Table 1).…”

“…However, because his deep tendon reflexes were brisk and he had normal sensation, it is unlikely that he had neuropathic tremor. Additionally, it is unlikely for phenobarbital to be a cause for tremor, because no associations have been reported so far 9 . Moreover, testosterone administration has been reported to improve tremor in Klinefelter's syndrome 10 …”

A Comprehensive Review of Secondary Movement Disorders

“…Antiseizure medications, also known as antiepileptic drugs (AEDs), are commonly used to treat epilepsy and other neurological disorders [37]. While these medications are effective in controlling seizures, some are associated with the development of movement disorders, known as antiepileptic drug-induced movement disorders (AEDIMDs) [38]. These movement disorders can vary in severity and presentation, highlighting the importance of monitoring and early recognition of these side effects [39].…”