Movement Disorders

Subbarao, Bruno S.; Eapen, Blessen C.

doi:10.1891/9780826147684.0050

Cited by 2 publications

(2 citation statements)

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“…Even when seizures are controlled with medication, it is essential to continue taking AEDs as prescribed since sudden withdrawal of AEDs can lead to seizures and other complications [ 2 ]. There are many different types of AEDs available, and the choice of medication depends on the type of seizure a person is experiencing, their age, and other factors such as other health conditions or medications they may be taking [ 3 ]. Some AEDs, such as phenytoin and carbamazepine, block the repetitive activation of sodium channels [ 4 ], while lacosamide enhances their slow inactivation [ 5 ].…”

Section: Overview Of Antiepileptic Drugsmentioning

confidence: 99%

Understanding Lamotrigine’s Role in the CNS and Possible Future Evolution

Costa

Vale

2023

IJMS

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The anti-epileptic drug lamotrigine (LTG) has been widely used to treat various neurological disorders, including epilepsy and bipolar disorder. However, its precise mechanism of action in the central nervous system (CNS) still needs to be determined. Recent studies have highlighted the involvement of LTG in modulating the activity of voltage-gated ion channels, particularly those related to the inhibition of neuronal excitability. Additionally, LTG has been found to have neuroprotective effects, potentially through the inhibition of glutamate release and the enhancement of GABAergic neurotransmission. LTG’s unique mechanism of action compared to other anti-epileptic drugs has led to the investigation of its use in treating other CNS disorders, such as neuropathic pain, PTSD, and major depressive disorder. Furthermore, the drug has been combined with other anti-epileptic drugs and mood stabilizers, which may enhance its therapeutic effects. In conclusion, LTG’s potential to modulate multiple neurotransmitters and ion channels in the CNS makes it a promising drug for treating various neurological disorders. As our understanding of its mechanism of action in the CNS continues to evolve, the potential for the drug to be used in new indications will also be explored.

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Section: Overview Of Antiepileptic Drugsmentioning

confidence: 99%

Understanding Lamotrigine’s Role in the CNS and Possible Future Evolution

Costa

Vale

2023

IJMS

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“…Most of these studies analysed small case series; thus, the actual incidence, risk factors, clinical course and prognosis are not clear. The risk factors of post-craniotomy headache reported in previous studies include muscle dissection, neural damage, patient position and anaesthetics (Lutman et al 2018, Subbarao et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of post-suboccipital craniotomy headache: A multicentre retrospective study

Shibata

Hatayama

Matsuda

et al. 2022

Journal of Perioperative Practice

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The detailed epidemiology and mechanism of post-craniotomy headaches are not well understood. This study aimed to establish the actual clinical incidence and causes of post-craniotomy headaches. Suboccipital craniotomy surgeries performed in six institutions within the five-year study period were included. This study included 311 patients (138 males, 173 female; mean age, 59.3 years old). A total of 145 patients (49%) experienced post-craniotomy headaches. Microvascular decompression surgery, craniectomy and facial spasms were significant risk factors for post-craniotomy headaches. In most cases, the post-craniotomy headaches disappeared within one month; however, some patients suffered from long-term headaches. The craniotomy site and the methods of dura and skull closures should be individually determined for each patient. However, to prevent post-craniotomy headaches, craniotomy, instead of craniectomy, may be considered.

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Movement Disorders

Cited by 2 publications

References 0 publications

Understanding Lamotrigine’s Role in the CNS and Possible Future Evolution

Understanding Lamotrigine’s Role in the CNS and Possible Future Evolution

Epidemiology of post-suboccipital craniotomy headache: A multicentre retrospective study

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