Movement of magnetic nanoparticles in brain tissue: mechanisms and impact on normal neuronal function

Ramaswamy, Bharath; Kulkarni, Sandip; Villar, Pablo S.; Smith, Richard; Eberly, Christian; Araneda, Ricardo C.; Depireux, Didier A.; Shapiro, Benjamin

doi:10.1016/j.nano.2015.06.003

Cited by 53 publications

(31 citation statements)

References 54 publications

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“…Detected MNPSNP clusters in the brain might be sporadically located inside larger blood vessels [66,67]. It is assumed that they did not cross the blood brain barrier and were transported via blood flow to other organs being trapped there [68][69][70]. In addition, MNPSNPs were not supposed to cause any damage in the brain Fig.…”

Section: Discussionmentioning

confidence: 99%

Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics

et al. 2020

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Background: In orthopedics, the treatment of implant-associated infections represents a high challenge. Especially, potent antibacterial effects at implant surfaces can only be achieved by the use of high doses of antibiotics, and still often fail. Drug-loaded magnetic nanoparticles are very promising for local selective therapy, enabling lower systemic antibiotic doses and reducing adverse side effects. The idea of the following study was the local accumulation of such nanoparticles by an externally applied magnetic field combined with a magnetizable implant. The examination of the biodistribution of the nanoparticles, their effective accumulation at the implant and possible adverse side effects were the focus. In a BALB/c mouse model (n = 50) ferritic steel 1.4521 and Ti90Al6V4 (control) implants were inserted subcutaneously at the hindlimbs. Afterwards, magnetic nanoporous silica nanoparticles (MNPSNPs), modified with rhodamine B isothiocyanate and polyethylene glycol-silane (PEG), were administered intravenously. Directly/1/7/21/42 day(s) after subsequent application of a magnetic field gradient produced by an electromagnet, the nanoparticle biodistribution was evaluated by smear samples, histology and multiphoton microscopy of organs. Additionally, a pathohistological examination was performed. Accumulation on and around implants was evaluated by droplet samples and histology.

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Section: Discussionmentioning

confidence: 99%

Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics

et al. 2020

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“…Determination of Cellular Uptake by TEM : To investigate the internalization and cytocompatibility, HepG2 cells were incubated with the nontargeted (MMSN‐S 2 ‐PEI‐PEG), single‐targeted (MMSN‐S 2 ‐PEI‐PEG‐PBA M−), and dual‐targeted (MMSN‐S 2 ‐PEI‐PEG‐PBA M+) formulations, during which a 0.3 T Nd‐Fe‐B button magnet was fixed beneath the plate of the dual‐targeted MMSN. After incubation at 37 °C for 6 h, cells were washed with PBS in triplicate, detached by 0.25% trypsin, and the cell suspension was centrifuged (2000 r min −1 , 10 min).…”

Section: Methodsmentioning

confidence: 99%

“…The body weight and tumor volume were monitored every 2 d. Tumors were dissected and measured to evaluate the therapeutic efficacy on 10th and 21st day, respectively. The inhibition rate (%) at 21st day was determined as ( C − T )/ C × 100%, where C was the tumor weight of the control group, and T was the tumor weight of each treated group …”

Section: Methodsmentioning

confidence: 99%

Controllably Switched Drug Release from Successively Dual‐Targeted Nanoreservoirs

Tang

Gao

et al. 2016

Adv Healthcare Materials

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The development of a nanocarrier with a capacity of releasing therapeutic agent "on demand" is of great importance for enhancing drug efficacy and reducing its side effect. Here, a multifunctional mesoporous silica nanoparticle is presented for cancer therapy. This nanoparticle can not only successively target tumor tissue and tumor cells but also has a function of controllably switching the drug release. Low molecular weight poly(ethyleneimine) segments, which are decorated on the surface of magnetic mesoporous silica nanoparticle with disulfide bonds, are chemically cross-linked, leading to the mesopores being "closed" in blood circulation but being "open" via taking off the coating in cytoplasm. As a result, the encapsulated drug can be kept in nanoparticles in the normal conditions, while be rapidly released in a reduction condition. In vivo antitumor activity demonstrates that this nanoparticle has the highest safety to body and the best therapeutic efficacy against tumors. Therefore, this work presents a good example of rational design of nanocarriers for highly effective cancer therapy.

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“…Note that particles are often treated by the FDA as drugs, although in Europe, they may be treated as devices. Studies of ex vivo vital rodent brain slices have shown that the presence of magnetic particles does not cause a measurable disruption of function [17]. In fact, it is not unusual for humans living in industrial cities to have magnetic particles in their brains, with no known related diseases [18].…”

Section: Particle Toxicitymentioning

confidence: 99%

Image-guided Placement of Magnetic Neuroparticles as a Potential High-Resolution Brain-Machine Interface

Weinberg¹,

Mair²,

Jafari³

et al. 2018

Evolving BCI Therapy - Engaging Brain State Dynamics

Self Cite

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We are developing methods of noninvasively delivering magnetic neuroparticles™ via intranasal administration followed by image-guided magnetic propulsion to selected locations in the brain. Once placed, the particles can activate neurons via vibrational motion or magnetoelectric stimulation. Similar particles might be used to read out neuronal electrical pulses via spintronic or liquid-crystal magnetic interactions, for fast bidirectional brain-machine interface. We have shown that particles containing liquid crystals can be read out with magnetic resonance imaging (MRI) using embedded magnetic nanoparticles and that the signal is visible even for voltages comparable to physiological characteristics. Such particles can be moved within the brain (e.g., across midline) without causing changes to neurological firing.

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Movement of magnetic nanoparticles in brain tissue: mechanisms and impact on normal neuronal function

Cited by 53 publications

References 54 publications

Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics

Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics

Controllably Switched Drug Release from Successively Dual‐Targeted Nanoreservoirs

Image-guided Placement of Magnetic Neuroparticles as a Potential High-Resolution Brain-Machine Interface

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