Movement of the Feline Esophagus Associated with Respiration and Peristalsis. AN EVALUATION USING TANTALUM MARKERS

Dodds, Wylie J.; Stewart, Edward T.; Hodges, Donald R.; Zboralske, F. Frank

doi:10.1172/jci107152

Cited by 126 publications

(70 citation statements)

References 8 publications

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“…Passage of the tail of intraluminal SO contrast medium, configured by the SO contraction, corresponded to upstroke onset of the peristaltic pressure complex. A similar relationship has been shown previously in the esophagus (15). In the SO, electrical spike bursts at a given level immediately preceded the onset of the manometric pressure complex and concurrent passage of the bolus tail.…”

Section: Myoelectric Activitysupporting

confidence: 85%

Motor function of the opossum sphincter of Oddi.

Toouli¹,

Dodds²,

Honda³

et al. 1983

J. Clin. Invest.

100

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A B S T R A C T We studied the opossum sphincter of Oddi (SO) because in this species the SO is -3 cm in length and its extraduodenal location permits recording of motor activity with negligible interference from duodenal motor activity. The SO cineradiography, CBD inflow of contrast medium, SO manometry, and SO electromyography indicated that rhythmic peristaltic contractions stripped contrast medium from the SO into the duodenum. During SO systole, CBD emptying was transiently interrupted, whereas SO filling occurred during the diastolic interval between SO peristaltic contractions. SO distention increased the frequency of SO peristalsis. We conclude that (a) the dominant feature of the opossum SO is rhythmic peristaltic contractions that originate in the proximal SO and propagate toward the duodenum; (b) these forceful SO peristaltic contractions are myogenic in origin and serve as a peristaltic pump that actively empties the SO segment; (c) CBD outflow occurs passively during SO diastole, but is interrupted transiently during each SO peristaltic contraction; and (d) a short HPZ with active as well as passive components exists in the distal SO segment and acts as a variable resistor to SO outflow.

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Section: Myoelectric Activitysupporting

confidence: 85%

Motor function of the opossum sphincter of Oddi.

Toouli¹,

Dodds²,

Honda³

et al. 1983

J. Clin. Invest.

100

View full text Add to dashboard Cite

show abstract

“…Perhaps this finding should not be too surprising: (a) atropine, which lowers LES pressure in normal subjects, does not increase the frequency of reflux (20,21); (b) considerable overlap of LES pressure exists between sample measurements obtained in control subjects and patients with reflux esophagitis (2); and (c) bethanechol-induced increases in LES pressure to about 30 mm Hg in patients with free GE reflux reduces, but does not abolish the reflux (22). In this study even a minimal basal LES pressure of [5][6][7][8][9][10] Before the meal, all the subjects were awake. During the first 3 h after eating most of the subjects remained fully awake, but several dozed.…”

mentioning

confidence: 85%

“…The reflux rate for the entire 12-h period was 0.9±0.6/h. Esophageal pH was <4.0 for 1.3 ±2.1% ofthe preprandial hour, 8.4±4.3% for the 3 h after eating, and 2.4±3.3% from 3-11 h after eating. The majority (82%) of episodes of acid GE reflux were associated with an identifiable common cavity phenomenon (11), manifested as an abrupt rise of 5-10 mm Hg in esophageal-body pressure so that intraesophageal pressure transiently equalled gastric pressure.…”

Section: Introductionmentioning

confidence: 91%

“…To permit infusion, the sleeve was connected at its proximal margin to the lumen of an underlying silicon rubber catheter. When infused, the sleeve functions as a variable resistor that gives an accurate continuous recording of LES pressure, despite oral-aboral motion ofthe LES (8,9) along the sleeve. With sphincter pullthrough methods, validation studies have shown that the sleeve sensor gives LES pressure values similar to those obtained by an infused catheter (7).…”

Section: Introductionmentioning

confidence: 99%

“…Generally, swallowing and primary peristalsis occurred when the subject was fully awake and during arousal periods from sleep, often as clusters of [5][6][7][8][9][10] swallows. During stable sleep, primary or secondary peristalsis occurred infrequently.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects.

Dent¹,

Dodds²,

Friedman³

et al. 1980

J. Clin. Invest.

864

472

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A B S T R A C T We investigated the mechanism of gastroesophageal reflux (GER) in 10 healthy volunteer subjects. Continuous recordings of intraluminal esophageal pH and pressure were obtained on two consecutive nights from 6:00 p.m. to 6:30 a.m. in each subject. During each study, the subject remained recumbent, except to eat a standardized meal after 1 h of basal recording. A manometric assembly with seven recording lumens monitored: (a) lower esophageal sphincter (LES) pressure via a sleeve device 6.5 cm in length, (b) esophageal-body motor activity, (c) swallowing activity in the pharynx, and (d) gastric pressure. An electrode 5 cm above the LES recorded esophageal pH. Sleep was monitored by electroencephalogram. All subjects showed wide variations ofbasal LES pressure. GER was not related to low steady-state basal LES pressure, but rather occurred during transient 5-30 s episodes of inappropriate complete LES relaxation. The inappropriate LES relaxations were usually either spontaneous or immediately followed appropriate sphincter relaxation induced by swallowing. The majority of GER episodes occurred within the first 3 h after eating. During the night LES relaxation and GER occurred only during transient arousals from sleep or when the subjects were fully awake, but not during stable sleep. After GER the esophagus was generally cleared of refluxed acid by primary peristalsis and less frequently by secondary peristalsis. Nonperistaltic contractions were less effective than peristalsis for clearing acid from the esophagus. We conclude that in asympto-A preliminary communication of this work was abstracted in 1978 (Gastroenterology. 74: 1119.) and was presented at the

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Instrumentation and Methods for Intraluminal Esophageal Manometry

Dodds¹

1976

Arch Intern Med

137

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Movement of the Feline Esophagus Associated with Respiration and Peristalsis. AN EVALUATION USING TANTALUM MARKERS

Cited by 126 publications

References 8 publications

Motor function of the opossum sphincter of Oddi.

Motor function of the opossum sphincter of Oddi.

Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects.

Instrumentation and Methods for Intraluminal Esophageal Manometry

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