Moving forward in plant food safety and security through NanoBioSensors: Adopt or adapt biomedical technologies?

Sharma, Tarun; Ramanathan, Rajesh; Rakwal, Randeep; Agrawal, Ganesh Kumar; Bansal, Vipul

doi:10.1002/pmic.201400503

Cited by 56 publications

(24 citation statements)

References 67 publications

(154 reference statements)

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“…4 Although recent market trends have clearly shown phytase to be an important enzyme, the feedstock processing conditions require improved thermostability of this enzyme to attain wider adaptability for industrial applications. [6][7][8][9][10] However, in all these cases, the recovery of the water-soluble enzyme to allow enzyme reusability remains challenging. [6][7][8][9][10] However, in all these cases, the recovery of the water-soluble enzyme to allow enzyme reusability remains challenging.…”

Section: Introductionmentioning

confidence: 99%

Charge-switchable gold nanoparticles for enhanced enzymatic thermostability

Shankar

Soni

Daima

et al. 2015

Phys. Chem. Chem. Phys.

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This study illustrates a facile strategy for efficient immobilization of enzymes on a metal nanoparticle surface. The strategy proposed here enables the enzymatic activity to be retained while increasing the enzyme thermostability. It is demonstrated that the use of a zwitterionic amino acid tyrosine as a reducing and capping agent to synthesise gold nanoparticles allows efficient immobilization of phytase enzyme through charge-switchable electrostatic interactions. The detailed kinetic and thermodynamic studies reveal that the proposed enzyme immobilization strategy improves the overall quality of phytase by reducing the activation energy required for substrate hydrolysis and broadening the temperature window in which immobilized enzyme is able to operate. The outcomes of this study indicate that the underlying zwitterionic nature of 20 natural amino acids along with significant variability in their isoelectric points and hydropathy indices as well the ability of some of the amino acids to reduce metal ions is likely to offer significant opportunities for tailoring nano-bio interfaces in a rational manner for a range of biological applications.

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Section: Introductionmentioning

confidence: 99%

Charge-switchable gold nanoparticles for enhanced enzymatic thermostability

Shankar

Soni

Daima

et al. 2015

Phys. Chem. Chem. Phys.

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“…The reminiscent biosensors are reported to determine these target analytes in biological matrices including human blood, sweat, saliva, urine, food products, environmental samples, etc. [5][6][7][8][9][10].…”

Section: History Definition and Classification Of Biosensorsmentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

190

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Due to the proliferative cancer rates, cardiovascular diseases, neurodegenerative disorders, autoimmune diseases and a plethora of infections across the globe, it is essential to introduce strategies that can rapidly and specifically detect the ultralow concentrations of relevant biomarkers, pathogens, toxins and pharmaceuticals in biological matrices. Considering these pathophysiologies, various research works have become necessary to fabricate biosensors for their early diagnosis and treatment, using nanomaterials like quantum dots (QDs). These nanomaterials effectively ameliorate the sensor performance with respect to their reproducibility, selectivity as well as sensitivity. In particular, graphene quantum dots (GQDs), which are ideally graphene fragments of nanometer size, constitute discrete features such as acting as attractive fluorophores and excellent electro-catalysts owing to their photo-stability, water-solubility, biocompatibility, non-toxicity and lucrativeness that make them favorable candidates for a wide range of novel biomedical applications. Herein, we reviewed about 300 biomedical studies reported over the last five years which entail the state of art as well as some pioneering ideas with respect to the prominent role of GQDs, especially in the development of optical, electrochemical and photoelectrochemical biosensors. Additionally, we outline the ideal properties of GQDs, their eclectic methods of synthesis, and the general principle behind several biosensing techniques.

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“…CNT-based electrochemical biosensing techniques can be used as clinical tools to detect protein cancer biomarkers [175][176][177]. Biosensors can also be used as platforms for monitoring food traceability, quality, safety and nutritional value [178,179]. However, these applications are categorized into 'single shot' analysis tools (cost-effective and disposable) and "long-term" monitoring analysis tools.…”

Section: Applications Of Cnt-based Biosensorsmentioning

confidence: 99%

A review on carbon nanotubes in biosensor devices and their applications in medicine

et al. 2018

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In recent years, integrating biological components in analytical instruments especially in biomedical research has become a prerequisite for early diagnosis of many diseases. It is well known that the material properties (electrical and physical) of CNTs is very sensitive to be affected by exposure to biomolecules and this led to the investigation by many researchers. Though the CNT-based biosensors has been widely used due their better performance, it still has many practical concerns in application. For the successful commercialization of the concept of CNT-based biosensors, many hurdles need to overcome. Modifications on CNT biosensors have experienced a dramatic change with outstanding developments. The present article provides an overview on the recent development in CNT biosensors and comprehensive analysis was given on various ways to improve the performance of CNT with new designs. In addition, some of the practical applications and concerns in the field are addressed. The scientific and technological challenges in the field are discussed in the conclusion.

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Moving forward in plant food safety and security through NanoBioSensors: Adopt or adapt biomedical technologies?

Cited by 56 publications

References 67 publications

Charge-switchable gold nanoparticles for enhanced enzymatic thermostability

Charge-switchable gold nanoparticles for enhanced enzymatic thermostability

Applications of Graphene Quantum Dots in Biomedical Sensors

A review on carbon nanotubes in biosensor devices and their applications in medicine

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