Moving forward: the nationwide advertising ban of areca nut in China

A scientometric study of betel quid chewing and oral cancer and precancerous lesions with distinct regional characteristic

“… 1 In some American and Eupean countries, areca nut selling is illegal. 9 , 10 Encouragingly, areca nut and BQ cessation program by multi-government ministries and agencies through collaboration has demonstrated a significant positive impact on oral cancer prevention in Taiwan region. 3 This program could date back to “Areca Prevention Day” on December 3, 1997 to raise public awareness on areca/BQ hazards by government administrations and agencies.…”

“…Owing to this program, BQ chewing prevalence has significantly decreased from near 18% in 2007 to less than 6% in 2018. 3 In mainland China, the National Radio and Television Administration requested to ban on the advertising of areca nut on September 17, 2021, 10 notwithstanding the sales method of areca nut has changed. 9 …”

Interleukin‐13 contributes to the occurrence of oral submucosal fibrosis

“…8,9 Interleukins (ILs) are cytokines that play an important role in the activation, differentiation, proliferation, maturation and migration of immune cells. 10 Studies have shown that IL-13 contributes to the pathogenesis of fibroproliferative diseases, such as pulmonary fibrosis, liver cirrhosis, myocardial fibrosis, progressive kidney disease and pathological skin scarring, among others. [11][12][13][14] Furthermore, IL-13 was associated with elevated production of total collagens in normal human skin and keloid fibroblasts (FBs), whereas FBs in various scarring diseases produced more fibrin, suggesting that IL-13 is associated with fibrosis.…”

“…Interleukins (ILs) are cytokines that play an important role in the activation, differentiation, proliferation, maturation and migration of immune cells 10 . Studies have shown that IL‐13 contributes to the pathogenesis of fibroproliferative diseases, such as pulmonary fibrosis, liver cirrhosis, myocardial fibrosis, progressive kidney disease and pathological skin scarring, among others 11–14 .…”