Moving from Batch to Continuous Operation for the Liquid Phase Dehydrogenation of Tetrahydrocarbazole

Shen, Yanchun; Ma’amor, Azman; Abu-Dharieh, Jehad; Thompson, Jillian M.; Kalirai, B.; Stitt, E. Hugh; Rooney, David

doi:10.1021/op400217d

Cited by 14 publications

(10 citation statements)

References 35 publications

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“…The transition from batch to flow operation conditions is not the ultimate goal for all industrial syntheses, especially in the case of well-established manufacturing processes. The possibility and profitability of such transformations have been the subject of much research in the past two decades [11][12][13][14][15] . Some researchers approached this issue in a very comprehensive and universal manner.…”

Section: Introductionmentioning

confidence: 99%

“…Similar work was performed by Teoh et al 17 by proposing practical assessment technology for converting fine chemicals production from batch to continuous. Nevertheless, the most important conclusion from these studies [11][12][13][14][15][16][17] is the need for an in-depth analysis of already performed research and the use of developed solutions.…”

Section: Introductionmentioning

confidence: 99%

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Catalytic hydrogenation of nitrocyclohexane as an alternative pathway for the synthesis of value-added products

Kowalewski

Śrębowata

2022

Catal. Sci. Technol.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Catalytic hydrogenation of nitrocyclohexane as an alternative pathway for the synthesis of value-added products

Kowalewski

Śrębowata

2022

Catal. Sci. Technol.

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“…In addition, experimental feasibility studies of the switch are very common. Some of these studies consider individual reactions of interest and typically involve synthesizing the desired chemical(s) in both batch reactors and CFRs and then comparing the reactor performance (see, for example, refs − ). A literature review of reactions carried out in CFRs is provided by Anderson .…”

Section: Introductionmentioning

confidence: 99%

Switching from Batch to Continuous Reactors Is a Trajectory Optimization Problem

Costandy

Edgar

Bâldea

2019

Ind. Eng. Chem. Res.

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Over the past two decades, the pharmaceutical and specialty chemical industries have led a considerable effort toward transitioning from existing batch to continuous flow processes. The transition promises many benefits, including improved automation, simpler scale-up, and higher throughput. The switch from batch reactor vessels to continuous flow reactors (CFRs) is among the most challenging problems that must be solved to succeed in making the batch to continuous process switch, and the best methodology by which the feasibility of the switch can be determined remains an open problem. In this work, we offer a novel, optimization-based framework for assessing the feasibility of the switch. Starting from first principles, we develop a general nondimensionalization algorithm for describing an arbitrary reactive system. We then define nondimensional performance metrics that allow us to assign "scores" for a given batch reactor or CFR. Finally, we construct two optimization problems that (1) minimize the difference in total performance between an existing batch reactor and a potential new CFR and (2) separately maximize the total performance of the two reactors. The design variables for each reactor are allowed to vary between realistic bounds for the particular reactor vessel type. Problem 1 provides insight into whether the switch is feasible, while problem 2 provides insight into whether the switch is desirable. Finally, we illustrate the utility of our framework using two case studies.

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“…Some successful stories have been nowadays demonstrated. Particularly, batch-to-continuous is one of the key issues for intensifying processes (Hellier et al, 2010;Anxionnaz et al, 2010;Elgue et al, 2012;Shen et al, 2014;Martin et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

What are the needs for Process Intensification?

Gourdon

Elgue

Prat

2015

Oil Gas Sci. Technol. – Rev. IFP Energies nouvelles

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Cet article fait partie du dossier thématique ci-dessous publié dans la revue OGST, Vol. 70, n°2, et téléchargeable ici D o s s i e rOil & Gas Science and Technology -Rev. IFP Energies nouvelles, Vol. 70 (2015), No. 3, Copyright © 2015, IFP Energies nouvelles > Editorial -Towards the Laboratory of the Future for the Factory of the FutureÉditorial -Vers le laboratoire du futur pour construire l'usine du futur Particularly, batch-to-continuous is one of the key issues for intensifying processes. But, the need of process intensification requires the need of collecting many new data of high quality relative to the chemical reaction and to the equipment as well, which represents sometimes a huge effort. This discussion is the opportunity to review the basic data and the metrology associated for the characterization of applications and technologies in order to guide the design of the intensified process. Concerning the chemicals, the stoechio-kinetics parameters, the phase equilibria data (for instance solubility) or the reaction enthalpies can be efficiently determined thanks to microfluidic devices. Concerning the equipment, benchmark studies have to be performed in view of comparing the technologies according to pressure drop, residence time distribution, heat and mass transfer performances, mixing efficiencies and so on. A way of capitalizing the background knowledge lies on simulation tools development, here called data processing tool. This presentation intends also to introduce some of the European network tools developed for diffusing the methodology of intensification, like the industrial club EUROPIC (European Process Intensification Centre) and the demonstration platform MEPI (Maison Européenne des Procédés Innovants).Résumé -Quels besoins pour intensifier un procédé ? -L'intensification des procédés est un concept désormais bien répandu au sein de la communauté du génie des procédés. Le développement de nouvelles voies chimiques et de technologies novatrices peut parfois conduire à des innovations de rupture. Il en a résulté un certain nombre de réussites industrielles. En particulier le passage batchcontinu est une des voies privilégiées pour intensifier un procédé. Mais si l'intérêt de l'intensification n'est plus à démontrer, il n'en demeure pas moins qu'elle nécessite d'acquérir un grand nombre de données relatives aussi bien à la voie chimique qu'au type d'équipement envisagé, ce qui représente un effort considérable. Cet article fait le point sur les données de base à acquérir et la métrologie associée pour concevoir un procédé intensifié. En ce qui concerne l'application chimique, on peut alors avoir recours aux outils microfluidiques pour acquérir de manière fiable et rapide les informations stoechiocinétiques et enthalpiques. En ce qui concerne l'équipement, des méthodes standards permettent de comparer les performances de diverses technologies en matière de perte de charge, distribution de temps de séjour, transferts de matière et de chaleur, mélange, etc. Une manière efficace de capitaliser la c...

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Moving from Batch to Continuous Operation for the Liquid Phase Dehydrogenation of Tetrahydrocarbazole

Cited by 14 publications

References 35 publications

Catalytic hydrogenation of nitrocyclohexane as an alternative pathway for the synthesis of value-added products

Catalytic hydrogenation of nitrocyclohexane as an alternative pathway for the synthesis of value-added products

Switching from Batch to Continuous Reactors Is a Trajectory Optimization Problem

What are the needs for Process Intensification?

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