2006
DOI: 10.1071/rd05120
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Moving to the beat: a review of mammalian sperm motility regulation

Abstract: Abstract. Because it is generally accepted that a high percentage of poorly motile or immotile sperm will adversely affect male fertility, analysis of sperm motility is a central part of the evaluation of male fertility. In spite of its importance to fertility, poor sperm motility remains only a description of a pathology whose underlying cause is typically poorly understood. The present review is designed to bring the clinician up to date with the most current understanding of the mechanisms that regulate spe… Show more

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Cited by 248 publications
(201 citation statements)
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References 152 publications
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“…sperm count and sperm motility, and did not reveal obvious ultrastructural sperm anomalies, we noticed a significant increase in the distance between the nuclear membrane and the capitulum when ODF1 is reduced. A larger distance between the nucleus and the capitulum most probably reflects weakening of sperm head-tail linkage that eventually might provoke decapitation potentially when hyperactivated in motility in the female oviduct (Turner 2006). In men, cases of infertility have already been reported in which spermatozoa are easily decapitated when manipulated for ICSI, but whether weakening of the HTCA is causative is not known (Kamal et al 1999).…”
Section: Discussionmentioning
confidence: 99%
“…sperm count and sperm motility, and did not reveal obvious ultrastructural sperm anomalies, we noticed a significant increase in the distance between the nuclear membrane and the capitulum when ODF1 is reduced. A larger distance between the nucleus and the capitulum most probably reflects weakening of sperm head-tail linkage that eventually might provoke decapitation potentially when hyperactivated in motility in the female oviduct (Turner 2006). In men, cases of infertility have already been reported in which spermatozoa are easily decapitated when manipulated for ICSI, but whether weakening of the HTCA is causative is not known (Kamal et al 1999).…”
Section: Discussionmentioning
confidence: 99%
“…Men with poorly motile or immotile sperm are typically infertile or sterile (Turner 2006). A deeper knowledge of the role of the NO/cGMP/ PRKG1 signaling pathway in the physiopathology of sperm motility could help to pharmacologically improve the fertilization capacity of human sperm or, alternatively, could lead to the development of an effective and safe male contraceptive based on sperm motility impairment.…”
Section: Discussionmentioning
confidence: 99%
“…The ability of sperm to move forward is crucial for the successful fertilization of an egg [3]. There is little information about the normal physiology of sperm motility or the proteins responsible for sperm function [4].…”
Section: Introductionmentioning
confidence: 99%