Moving toward affective immunology: Legacy and future directions

Alzheimer's disease and related dementias (ADRD) pose a massive public health challenge, affecting over 6.7 million Americans aged 65 and older—a number projected to double by 2050. Despite advances in pharmacological treatments, there remains no cure or method to reverse the disease. This paper highlights the role of psychological stress as a critical yet underappreciated risk factor for cognitive decline and reviews its complex interplay with behavioral, social, and biological mechanisms. Chronic psychological stress drives physiological and behavioral changes that are linked to accelerated cognitive deterioration, particularly in older adults. Early interventions can target stress management and behavioral prevention strategies, which include physical activity, healthy diet, and social engagement. Further, key barriers to meaningful policy change to prevent and slow ADRD include lack of public awareness, stigma around mental health and aging, and misaligned funding incentives. Policy initiatives can improve brain health literacy, increase equitable access to services, and enhance community-level and environmental factors to promote healthy aging. Prioritizing stress reduction and promoting early detection and prevention can meaningfully reduce ADRD risk and progression, improving public health broadly.

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Moving toward affective immunology: Legacy and future directions

Cited by 3 publications

References 193 publications

Introduction to the special issue: A festschrift for Janice Kiecolt-Glaser – At the origin of stress and immunity

Introduction to the special issue: A festschrift for Janice Kiecolt-Glaser – At the origin of stress and immunity

Neuropsychiatric drug development: Perspectives on the current landscape, opportunities and potential future directions

Psychological Stress and Cognitive Brain Health: Policies to Reduce Dementia Risk

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